Malene Hansen Lab

Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

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Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

The Bradley Lab is focused on understanding the regulation of T lymphocytes in virus infections where the immune response results...

All Scientists
Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children's Health Research Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

All Scientists
Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

The Bradley Lab is focused on understanding the regulation of T lymphocytes in virus infections where the immune response results...

All Scientists
Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children's Health Research Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP drug discovery projects by disease area
Learn more
Drug discovery projects
Caroline Kumsta @ Malene Hansen Lab
Paper of the Week
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
Microglia (red, nuclei) phagocytosing amyloid (green)
Beaker Blog February 16, 2017
Treating Alzheimer’s by stimulating the brain’s rubbish collectors
In Alzheimer’s disease, the space around brain cells becomes clogged with toxic clumps of protein called amyloid. The problem isn’t just that amyloid is generat...
Read more
Caroline Kumsta, Ph.D.
Press Release
February 15, 2017
What doesn’t kill you makes you stronger
Biologists have known for decades that enduring a short period of mild stress makes simple organisms and human cells better able to survive additional stress la...
Andrea Davidson
Press Release
February 13, 2017
Andrea Davidson joins SBP as vice president of philanthropy
Sanford Burnham Prebys Medical Discovery Institute (SBP) has named Andrea Davidson as the new vice president of philanthropy. In her new position, Davidson will...
Ashima Shukla, Ph.D.
Beaker Blog February 9, 2017
Ashima Shukla wins fellowship for research to improve B cell lymphoma treatment
Although every tumor is different, diffuse large B cell lymphomas are generally treated as a single disease. One reason is that advanced genomic sequencing—a me...
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Heart Cardiogram
Beaker Blog February 6, 2017
Getting to the bottom of potentially fatal heart rhythm defects
Imagine your otherwise healthy child fainted while playing soccer and was diagnosed with long QT syndrome, a heart rhythm problem that can cause the heart to st...
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The Browars with two STRIVE recipients
Beaker Blog February 3, 2017
Scientists and donors gather for STRIVE
Every new medicine starts with an idea, and today, Sanford Burnham Prebys Medical Discovery Institute (SBP) scientists and donors gathered to hear updates on ST...
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hands holding heart
Beaker Blog February 1, 2017
An “Odd” gene affects aging of the heart
As we get older, our hearts change in ways that make it harder for them to pump blood. They become stiffer, less efficient at generating energy, and more likely...
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Muthu Periasamy, Ph.D.
Beaker Blog January 26, 2017
Does cold weather promote weight loss?
Winter brings cold. Muthu Periasamy, Ph.D. , professor at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, studies how muscle burns calori...
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artistic rendering of lungs
Beaker Blog January 25, 2017
A promising personalized approach to treat small cell lung cancer
Small cell lung cancer (SCLC), which accounts for 10-15 percent of all lung cancer cases, is extremely aggressive, with a five-year survival rate of about two p...
Read more
B Cell Press Photo
In the News
January 25, 2017
Antibody-making B cells' metabolic switch found
The San Diego Union-Tribune
Alzheimer's Disease
In the News
January 25, 2017
San Diego Alzheimer’s Researcher Says Large Knowledge Gaps Remain
KPBS
30K

One in 30,000 babies are born with ALGS.

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Support us

Our focus in February is Alagille Syndrome (ALGS), a rare genetic disorder that can affect the liver, heart, eyes, and other parts of the body.  Help us translate our scientific discoveries into better patient treatments in the future.  

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