Malene Hansen Lab

Our Path Starts Here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

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Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

Dr. Bradley's lab's research focus is to identify parameters that control the development of effector and memory CD4 T cells and h...

All Scientists
Neuroscience

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
Huaxi Xu, Ph.D., in the lab
Meet a Scientist

Huaxi Xu, Ph.D.

Professor, Degenerative Diseases Program

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Sanford Children's Health

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children’s Health Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

All Scientists
Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

Dr. Bradley's lab's research focus is to identify parameters that control the development of effector and memory CD4 T cells and h...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Neuroscience

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Huaxi Xu, Ph.D., in the lab
Meet a Scientist

Huaxi Xu, Ph.D.

Professor, Degenerative Diseases Program

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
Sanford Children's Health

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children’s Health Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP drug discovery projects by disease area
Learn more
Drug discovery projects
family running
Beaker Blog December 6, 2016
Research could ease the transition to an active lifestyle
If you don’t exercise regularly, your muscles become less able to support physical activity, so you tire out quickly. That makes it extremely difficult for sede...
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ani deshpanda, ph.d.
Beaker Blog December 2, 2016
V Foundation grant to Ani Deshpande, Ph.D., supports pioneering research toward better leukemia treatments
Patients with a rare type of leukemia called acute promyelocytic leukemia (APL) have better outcomes than most leukemias because they can be treated with a very...
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project planning meeting
Beaker Blog November 29, 2016
SBP is building capabilities in project and alliance management
Sanford Burnham Prebys Medical Discovery Institute (SBP) has long been known for exceptional science, and now a new program at the Institute focused on project...
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Paper of the Week: Zhou Lab Image
Paper of the Week November 28, 2016
miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila
miR-34 overexpression and deficiency, respectively, enhances and impairs innate immunity in vivo miR-34 represses a suite of novel target genes including Dlg1 a...
Part of Team SBP at Petco Park. From left: James Short, Lix Schwarzbach, Marco Maruggi
Beaker Blog November 16, 2016
At Pedal the Cause, Team SBP rode 787 miles for cancer research in San Diego
Over a blisteringly hot November weekend, scientists, staff, and supporters of Sanford Burnham Prebys Medical Discovery Institute came together to support the f...
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Laszlo Nagy Lab
Paper of the Week November 15, 2016
Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration
Macrophage PPARγ is required for skeletal muscle regeneration PPARγ regulates GDF3 in muscle infiltrating LyC6 - repair macrophages The Gdf3 locus has multiple...
woman swimming on her back
Beaker Blog November 15, 2016
Long-term exercise makes fat better at burning calories, but doesn’t turn it brown
Brown fat is good, white fat bad. That’s the impression given by recent metabolism research focused on how to make white fat, which stores energy, more like the...
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Ze'ev Ronai, Ph.D.
Beaker Blog November 10, 2016
Ze’ev Ronai wins Lifetime Achievement Award from the Society for Melanoma Research
Ze’ev Ronai, Ph.D. , chief scientific advisor at Sanford Burnham Prebys Medical Research Institute (SBP) and professor in its NCI-designated Cancer Center , is...
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Fluorescently stained section of muscle tissue
Beaker Blog November 8, 2016
How the immune system helps build muscle
Laszlo Nagy, M.D., Ph.D. , professor and director of the Genomic Control of Metabolism Program , recently led research that pinpoints a connection between the i...
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SBP is working hard to find better treatments for prostate cancer.
Beaker Blog November 7, 2016
Beating Prostate Cancer
About one in seven men will be diagnosed with prostate cancer during his lifetime. Though it has one of the highest survival rates of any type of cancer—95% mak...
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Healthy pancreatic islet; beta cells in green and alpha cells in red
Beaker Blog November 3, 2016
Scientists find molecular switch to regenerate insulin-producing cells
Future drugs could stimulate cells in the pancreas of diabetics to become insulin makers
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Abnormal blood vessels in patient with diabetic retinopathy
Beaker Blog October 31, 2016
New paths to treating visual complications of diabetes
Up to 80 percent of people who have had diabetes for more than 20 years develop diabetic retinopathy, putting them at risk for major vision loss. Current treatm...
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60%

Inflammatory bowel diseases (IBD), which include Crohn’s disease and colitis, can increase your risk of intestinal cancer by as high as 60%.

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Support us

This December, we're focusing on Crohn’s disease and colitis. Help us translate our scientific discoveries into better patient treatments in the future.  

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