Malene Hansen Lab

Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

The Bradley Lab is focused on understanding the regulation of T lymphocytes in virus infections where the immune response results...

All Scientists
Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Sanford Children's Health

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children’s Health Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Brooke Emerling
Meet a Scientist

Brooke Emerling, Ph.D.

Assistant Professor, Cancer Metabolism and Signaling Networks Program

Dr. Emerling’s research focuses on the role of the PI5P4K enzymes in cancer metabolism.

All Scientists
Robert Wechsler-Reya, Ph.D., haedshot
Meet a Scientist

Robert Wechsler-Reya, Ph.D.

Director and Professor, Tumor Initiation and Maintenance Program

Dr. Wechsler-Reya’s research focuses on the molecular mechanisms that regulate cell growth and tumorigenesis in the nervous system...

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Sheila Collins, Ph.D. headshotl
Meet a Scientist

Sheila Collins, Ph.D.

Professor, Integrative Metabolism Program

Dr. Collins's laboratory is interested in the biochemical mechanisms that regulate body weight. 

All Scientists
Peter Crawford, M.D., Ph.D., headshot
Meet a Scientist

Peter Crawford, M.D., Ph.D.

Director and Associate Professor, Cardiovascular Metabolism Program

Dr. Crawford's research focuses on the interplay between intermediary metabolism and the processes of obesity and cardiovascular d...

All Scientists
Dan Kelly, M.D. headshot
Meet a Scientist

Daniel Kelly, M.D.

Tavistock Distinguished Professor and Scientific Director, SBP at Lake Nona

Dr. Kelly's lab studies gene regulation of cell energy in diabetes and heart failure.

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Sumit Chanda, Ph.D. headshot
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Linda Bradley, Ph.D. headshot
Meet a Scientist

Linda Bradley, Ph.D.

Professor, Immunity and Pathogenesis Program

The Bradley Lab is focused on understanding the regulation of T lymphocytes in virus infections where the immune response results...

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Malene Hansen, Ph.D., headshot at a microscope
Meet a Scientist

Malene Hansen, Ph.D.

Associate Professor, Development, Aging and Regeneration Program

The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.

All Scientists
huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Pier Lorenzo Puri, M.D., Ph.D, headshot
Meet a Scientist

Pier Lorenzo Puri, M.D., Ph.D.

Professor, Development, Aging and Regeneration Program

The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in e...

All Scientists
Sanford Children's Health

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Fred Levine, M.D., Ph.D. headshot
Meet a Scientist

Fred Levine, M.D., Ph.D.

Director, Sanford Children’s Health Center

Dr. Levine's lab continues to pursue the development of cell therapies for diabetes using a variety of approaches, including high...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Assistant Professor, Human Genetics Program

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP drug discovery projects by disease area
Learn more
Drug discovery projects
Nature Immunology Logo
Paper of the Week
Gsk3 is a metabolic checkpoint regulator in B cells
Germinal center (rectangle) in the spleen of an immunized mouse, showing inactivated GSK3 (magenta) in B cells (blue) near follicular dendritic cells (green).
Press Release
January 23, 2017
Research helps explain how B cell metabolism is controlled
B cells, the lymphocytes best known for making antibodies, live a complex life. They start developing in the bone marrow and then move through the spleen, lymph...
robotic arm at the Prebys Center in Lake Nona
Beaker Blog January 18, 2017
Florida Translational Research Program funding re-fuels drug discovery collaborations with leading research institutions
Reinstatement of Florida Translational Research Program (FTRP) funding has provided scientists at Florida universities and medical research institutes with rene...
Read more
student writing on chalkboard
Beaker Blog January 18, 2017
“Chalk talks” foster community among San Diego stem cell researchers
Many scientists in San Diego, and particularly on the Torrey Pines mesa, are working on therapies that rely on stem cell biology—modeling diseases for drug disc...
Read more
generic cell-related
Beaker Blog January 17, 2017
How the enzymes that “tidy up” a cell are turned off and on
When a cell has too much of a certain kind of machine or sensor, the extras are tagged for destruction. That tagging is carried out by enzymes that serve as the...
Read more
gut microbiome cartoon
Beaker Blog January 17, 2017
Scott Peterson receives grant to discover gut microbiome-targeted therapies
The gut microbiome—the trillions of bacteria and other microscopic bugs in your intestine—is a hot topic in medical research. The number scientific studies show...
Read more
red and white blood cells and antibodies
Beaker Blog January 17, 2017
Research reveals the function of a pivotal protein impacting immunity and lymphoma
Robert Rickert, Ph.D. , professor at SBP, and his team have recently published discoveries in The Journal of Immunology that may open a new avenue of treatment...
Read more
Malene Hansen, Ph.D.
Press Release
January 13, 2017
Malene Hansen receives Mentor Award from National Postdoctoral Association
Malene Hansen, Ph.D., associate professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), has been named the recipient of the 2017 Garnett-Powers & Associates, Inc. Mentor Award from the National Postdoctoral Association (NPA). Hansen is being honored for her “positive influence on postdoctoral training at San Diego institutions” and her “commitment to mentoring and service.”
Drug Courier
In the News
January 12, 2017
Top 100 Stories of 2016: #26 Drug Couriers for Brain Injuries
A small protein could lead to a cure for traumatic brain injuries.
woman exercising on bike in gym
Beaker Blog January 9, 2017
Bret Goodpaster to lead part of $170M NIH effort to understand the molecular effects of exercise
Everyone knows that physical activity is good for your health, but we’re far from understanding all the details of how exercise improves the function of the cel...
Read more
Robert Rickert Lab
Paper of the Week
Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation
MRI of patient with hydrocephalus
Press Release
December 14, 2016
Research identifies a molecular basis for common congenital brain defect
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have discovered a molecular cause of hydrocephalus, a common, potentially life-threatenin...
#1

Heart disease is the leading cause of death for both women and men. 

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New Year, New You! Treat your heart right as we focus on cardiovascular diseases in January. Help us translate our scientific discoveries into better patient treatments in the future.  

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