Layton Smith

Layton Smith, Ph.D.[Lake Nona in Orlando]

  • Director, Drug Discovery Florida
  • Research

    Dr. Smith studies the role of apelin and its receptor in cardiovascular function.

  • Biography

    Dr. Smith received his Ph.D. in Pharmacology in 2002 from Vanderbilt University, Nashville, Tennessee.

Layton Smith's Research Focus

Cardiovascular Diseases, Atherosclerosis, Hypertension, Metabolic Syndrome

Layton SmithWatch Dr. Smith describe his research

The Smith lab focuses on identifying molecular mechanisms of increased risk for cardiovascular disease in the metabolic syndrome, by studying apelin, a vasoactive peptide that increases cardiac contractility and decreases vascular tone to reduce blood pressure. Paradoxically, this vasoprotective peptide is over-produced by fat in obese people, but fails to elicit the positive effects on the cardiovascular system. To address this paradoxical effect, Smith employs molecular biology, cellular and animal models, novel pharmacologic tools and is currently developing cell-based assays to identify small molecule probes of the apelin receptor using a HTS strategy.

About Layton Smith


Layton Smith, Ph.D., received his Doctorate degree (Pharmacology, 2002) from Vanderbilt University, Nashville, Tennessee, where he also received his postdoctoral training in Clinical Pharmacology and Cardiovascular Medicine. Dr. Smith is a Florida native and returned to his home state in 2005, to join The Scripps Research Institute in Jupiter, Florida, as an Assistant Professor in the Biomedical Sciences program, as well as Associate Director of Pharmacology. He was recruited to the position of Assistant Professor at Sanford-Burnham Medical Research Institute in 2007, where he also serves as the Director of the Pharmacology core service.

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