Pier Lorenzo Puri, M.D., Ph.D.[La Jolla]
There’s an emotional charge in my lab. We know there are children waiting for us to do our jobs, and when we work we are targeting those faces, those smiles.
Dr. Puri investigates the molecular mechanisms underlying the reprogramming of the genome during cell lineage commitment.
Dr. Puri earned his M.D. in 1991 and his Ph.D. in 1997 at the University of Rome “la Sapienza”.
Selective control of Pax7 expression by TNF-activated p38α/polycomb repressive complex 2 (PRC2) signaling during muscle satellite cell differentiation.
Mozzetta C, Consalvi S, Saccone V, Forcales SV, Puri PL, Palacios D
Cell Cycle. 2011 Jan 15;10(2):191-8
An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis.
Innocenzi A, Latella L, Messina G, Simonatto M, Marullo F, Berghella L, Poizat C, Shu CW, Wang JY, Puri PL, Cossu G
EMBO Rep. 2011 Feb;12(2):164-71
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL
Cell Stem Cell. 2010 Oct 8;7(4):455-69
SWI/SNF complexes, chromatin remodeling and skeletal myogenesis: it's time to exchange!
Albini S, Puri PL
Exp Cell Res. 2010 Nov 1;316(18):3073-80
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009 Dec;17(6):836-48
Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration.
Guasconi V, Puri PL
Trends Cell Biol. 2009 Jun;19(6):286-94
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.
Colussi C, Mozzetta C, Gurtner A, Illi B, Rosati J, Straino S, Ragone G, Pescatori M, Zaccagnini G, Antonini A, Minetti G, Martelli F, Piaggio G, Gallinari P, Steinkuhler C, Steinkulher C, Clementi E, Dell'Aversana C, Altucci L, Mai A, Capogrossi MC, Puri PL, Gaetano C
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19183-7
Regenerative pharmacology in the treatment of genetic diseases: the paradigm of muscular dystrophy.
Mozzetta C, Minetti G, Puri PL
Int J Biochem Cell Biol. 2009 Apr;41(4):701-10
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.
Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL
Mol Cell. 2007 Oct 26;28(2):200-13
DNA damage and cellular differentiation: more questions than responses.
Simonatto M, Latella L, Puri PL
J Cell Physiol. 2007 Dec;213(3):642-8
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Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles.
Fiacco E, Castagnetti F, Bianconi V, Madaro L, De Bardi M, Nazio F, D'Amico A, Bertini E, Cecconi F, Puri PL, Latella L
Cell Death Differ. 2016 Jul 22;
Pier Lorenzo Puri's Research Focus
Muscular Dystrophy, Cancer
Puri’s lab group investigates of the molecular mechanism underpinning the genome reprogramming during cell lineage commitment and terminal differentiation of embryonic and adult stem cells, and during induced pluripotency.
The Puri Lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in embryonic and adult stem cells. The lab is especially interested in skeletal muscle progenitors, and one area of focus is how deregulated gene expression in these cells leads to development of rhabdomyosarcoma (RMS).
We have a specific interest toward the mechanism by which the cues released within the regenerative environment are converted by intracellular signalling into the epigenetic information that controls gene expression in muscle stem cells and other cellular components of their niche.
Our area of investigation include 1) the impact of regeneration cues on the ability of muscle progenitors to proliferate and differentiate into skeletal myofibers; 2) the discovery of pharmacological interventions that promote muscle regeneration to repair diseased muscles, and in particular dystrophic muscles; 3) the ability of extra-cellular signal activated kinases to influence the assembly of chromatin-associated complexes that regulate gene transcription during cellular regeneration, differentiation, and neoplastic transformation; 4) the epigenetic networks that regulate embryonic stem cell commitment toward different lineages and induced pluripotency in somatic cells; 5) the mechanism that maintains the genomic integrity in differentiation-committed cells exposed to genotoxic agents; 6) the molecular relationship between DNA damage, terminal differentiation and senescence during organismal aging.
Pier Lorenzo Puri's Research Report
Pier Lorenzo Puri
About Pier Lorenzo Puri
Pier Lorenzo Puri earned his M.D. at the University of Rome “la Sapienza” in 1991. Dr. Puri completed his internship in Internal Medicine at the hospital "Policlinico Umberto I" (Rome) from 2002 to 2007, and earned his Ph.D. at the University of Rome “la Sapienza” in 1997. During this time he was frequently working at the Freien University of Berlin, as visiting scientist. Dr. Puri trained as a post-doctoral fellow at the University of California San Diego (UCSD), in the department of Cell Biology, under the supervision of Dr. Wang, from 1997 to 2001. He was appointed as Staff Scientist at the Salk Institute (La Jolla) in 2001, and became an Assistant Telethon Scientist at the Dulbecco Telethon Institute in Rome in 2002. He was upgraded to Associate Telethon Scientist at the Dulbecco Telethon Institute in Rome since 2007. Dr. Puri joined Sanford-Burnham Medical Research Institute as an Assistant Professor in 2004. He has been promoted to Associate Professor in 2010. Since 2008 Dr. Puri is Adjunct Professor of Pediatrics at the University of California, San Diego and Associate Member of Sanford Children’s Health Research Center (Muscle Development and Regeneration program).
Univ. of Rome La Sapienza, Undergraduate, Internal Medicine
Univ. of Rome La Sapienza, M.D., Internal Medicine
Univ. of Rome la Sapienza, Ph.D. , Internal Medicine
Univ. of California, San Diego, Postdoctoral, Dept. of Biology
Associate Scientist, Dulbecco Telethon Institute, Roma, Italy
Associate Adjunct Professor, Dept. Of Pediatrics, UCSD
Associate Member, Sanford Children’s Health Research Center