Richard Pratley

Richard Pratley, M.D.[Lake Nona in Orlando]

Obesity and diabetes are epidemic. They account for substantial morbidity, mortality and costs. Novel strategies to prevent and treat diabetes and its complications are desperately needed. By targeting the pathophysiology of obesity-related diabetes and performing preclinical and clinical studies in parallel, we hope to accelerate the discovery of new targets for therapies. Sanford-Burnham, in collaboration Florida Hospital and the Translational Research Institute for Metabolism and Diabetes, provide unparalleled opportunities for advancing new discoveries into the clinic.

  • Research

    Dr. Pratley focuses on the role of adipose tissue and adipocyte secreted products in the pathogenesis of type 2 diabetes.

  • Biography

    Dr. Pratley received his M.D. from Wayne State University, Detroit, MI.



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Richard Pratley's Research Focus

Aging-Related Diseases, Metabolic Syndrome, Monogenic Diabetes, Diabetes - General, Type 1 Diabetes, Type 2 Diabetes, Alzheimer's Disease

The aims of the Pratley lab are to:
1. Understand the role adipocyte proliferation and differentiation play in the pathogenesis of insulin resistance and type 2 diabetes.
2. Understand how glucose-dependent insulinotropic peptide (GIP) signaling is altered in obesity and type 2 diabetes and how this contributes to metabolic dysfunction.
3. Understand the mechanisms leading to dysregulation of amyloid precursor protein (APP) and its cleavage products in obesity and type 2 diabetes and how this contributes to inflammation and metabolic dysfunction.

About Richard Pratley


Richard E. Pratley, M.D., is a graduate of Wayne State University School of Medicine in Detroit, Michigan, and trained in internal medicine at the University of Michigan in Ann Arbor. He served as Head of the Diabetes and Metabolism Unit of the National Institutes of Health Clinical Diabetes and Nutrition Section in Phoenix, Arizona, before taking a position as Senior Director in the Cardiovascular and Metabolism Therapeutic Area at Novartis Pharmaceuticals, where he worked on the clinical development of new drugs for diabetes until 2004. From 2004-2011, Dr. Pratley was Professor of Medicine, University of Vermont College of Medicine and Director of the Diabetes and Metabolism Translational Medicine Unit. His current research interests include the prevention of diabetes, improving the care for persons with diabetes, developing new drugs to treat and prevent diabetes and its complications, and understanding the role of the fat cell in increasing the risk for diabetes and heart disease.

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M.D., Wayne State University, Detroit, MI
B.S. with Honors, Cell and Molecular Biology, University of Michigan, Ann Arbor, MI

Other Appointments

Director, Florida Hospital Diabetes Institute
Senior Scientist, Florida Hospital – Sanford-Burnham Translational Research Institute for Metabolism and Diabetes

Honors and Recognition

Best paper published in the journal Obesity, 2009
Henry Christian Award for Excellence in Clinical Research, American Federation for Clinical Research, 1992

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