Our next goal is to look for more genes that interact with Tinman or with other factors that we know are important for the heart.
Dr. Bodmer focuses on the molecular mechanisms of organ formation and the genetic basis of heart development and performance.
Dr. Bodmer earned his Ph.D. in Biochemistry and Neurobiology from the University of Basel, Switzerland, in 1983.
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R
J Cell Biol. 2011 Jun 27;193(7):1181-96
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.
Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S
Cell Metab. 2010 Nov 3;12(5):533-44
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM
Cell. 2010 Apr 2;141(1):142-53
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M
Science. 2010 Mar 5;327(5970):1223-8
d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.
Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, Lim HY, Elmén L, Hayes M, Oldham S, Bodmer R
Aging Cell. 2009 Sep;8(5):542-52
Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.
Qian L, Mohapatra B, Akasaka T, Liu J, Ocorr K, Towbin JA, Bodmer R
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19833-8
Genetic control of heart function and aging in Drosophila.
Ocorr K, Perrin L, Lim HY, Qian L, Wu X, Bodmer R
Trends Cardiovasc Med. 2007 Jul;17(5):177-82
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.
Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3943-8
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.
Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z
Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13520-5
Slit and Robo control cardiac cell polarity and morphogenesis.
Qian L, Liu J, Bodmer R
Curr Biol. 2005 Dec 20;15(24):2271-8
Insulin regulation of heart function in aging fruit flies.
Wessells RJ, Fitzgerald E, Cypser JR, Tatar M, Bodmer R
Nat Genet. 2004 Dec;36(12):1275-81
Heart development in Drosophila requires the segment polarity gene wingless.
Wu X, Golden K, Bodmer R
Dev Biol. 1995 Jun;169(2):619-28
INFLUENCE OF HYPOXIA AND ADRENALINE ADMINISTRATION ON CORONARY BLOOD FLOW AND CARDIAC PERFORMANCE IN SEAWATER RAINBOW TROUT (ONCORHYNCHUS MYKISS)
Gamperl A, Pinder A, Grant R, Boutilier R
J Exp Biol. 1994 Aug;193(1):209-32
The gene tinman is required for specification of the heart and visceral muscles in Drosophila.
Development. 1993 Jul;118(3):719-29
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A restrictive cardiomyopathy mutation in an invariant proline at the myosin head/rod junction enhances head flexibility and function, yielding muscle defects in Drosophila.
Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI
J Mol Biol. 2016 Apr 20;
Rolf Bodmer's Research Focus
Cardiovascular Diseases, Heart Disease, Inherited Disorders, Muscular Dystrophy, Metabolic Syndrome, Metabolic Diseases, Obesity, Neurodegenerative and Neuromuscular Diseases, Parkinson's Disease, Cancer
Watch Dr. Bodmer describe his research
The Bodmer Laboratory is interested in the molecular mechanisms of organ formation, how patterns are generated and how cells and tissue types assume their correct fates and functions. The Bodmer lab is pursuing this interest by studying the genetic functions and interactions that specify heart development and maintain heart performance in the Drosophila model, in the hope of elucidating basic principles in organogenesis and functionality.
Cardiac Cell Types
We study the HIF and Notch pathways in various organismal responses to hypoxia. Both of these pathways as well as mechanisms and responses to hypoxia are of high relevance to cancer research.
We are also studying master regulatory networks in how they control metabolism and obesity. These fundamental studies on obesity pathways will also be highly relevant to cancer metabolism.
About Rolf Bodmer
Rolf Bodmer earned his Ph.D. in Biochemistry and Neurobiology from the University of Basel, Switzerland, in 1983. Dr. Bodmer trained as a postdoctoral fellow in Neurobiology at the Albert Einstein College of Medicine in New York, and also studied Molecular Genetics at the University of California, San Francisco. He was appointed Assistant Professor of Biology in 1990 at the University of Michigan. There, he was promoted to Associate Professor of Biology in 1996, and then appointed to Associate Professor of Molecular, Cellular and Developmental Biology in 2001. Dr. Bodmer joined Sanford-Burnham Medical Research Institute in 2003, where he is Professor and Program Director of the Development, Aging, and Regeneration Program.
Adjunct professor, University of California, San Diego
Funding Awards and Collaborative Grants
1 P01 AG033561 "Genetic Analysis of Drosophila Functional Aging"
Honors and Recognition
Ellison Foundation Senior Scholar Award