Working at SBP
With more than 1,000 employees across the country, we're a world-class research institute that’s still small enough to feel like home. We take pride in offering competitive salaries and benefits that provide flexibility for the diverse and changing needs of our employees. What’s more, we are located in science and technology hotbeds. They're remarkable cities that also just happen to be beautiful places to live.
Directing differentiation of stem cells, endogenous cardiac progenitors or cardiac fibroblasts to create new muscle is an aspiration of regenerative medicine. To that end, it is crucial to comprehensively identify and characterize gene regulatory networks controlling cardiac cell fate. To date, less than 30 genes have been tested for their ability to induce cardiac reprogramming, showing only modest effects when overexpressed in fibroblasts. This project is to use high-throughput functional screening strategies in order to identify new determinants of cardiac cell fate and evaluate their role both in vitro and in adult models of cardiac regeneration.
The Colas lab is located at Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) which stands at the forefront of basic biomedical and translational science. The institute provides world-class facilities, including one of the 4 nationwide screening centers, and a cooperative environment, which promotes productive collaborations.
1 AR. Colas et al. 2016. Submitted to Cell Stem Cell
2 T. Cunningham, A Colas et al. 2015. Plos One
3 M. Mercola, A Colas et al. 2013. Cardiovascular Drug Discovery Circ Res
4 A. Colas et al. 2012. Genes and Development
5 W. McKeithan*, A. Colas* et al. 2012. Curr Protoc Stem Cell Biol
Applicants must have a Ph.D or M.D, be highly motivated, and have a track record of accomplishments (i.e one or more first-authored publications). Experience in one or more of the following areas is required: developmental biology, stem cell biology, mouse models and high-throughput screening.
To apply, please send a CV, a brief statement of your previous research expertise, and the contact information of three references via the Apply button below.
The Postdoctoral Associate will be responsible for conducting chemical biology research through development and use of biochemical and biophysical assays of novel biological targets from diverse classes and therapeutic areas. The work will be conducted at Prebys Center, the state-of-the art drug discovery Center at Sanford Burnham Prebys Medical Discovery Institute.
Duties and Responsibilities:
- Independently designs and performs experiments and procedures with high degree of complexity, demonstrating increasing expertise with a wide range of techniques.
- Demonstrates flexibility in adapting methods/skills according to evolving project priorities.
- Provides independent experimental design and follow up planning, interpretation of results and evaluation of data.
- Able to analyze and interpret data from different sources and draw relevant conclusions.
- Demonstrates knowledge in specialized disciplines.
- Presents results within lab, and at external meetings.
- Accurately documents experiments in lab notebook.
- Contributes to writing of reports and manuscripts, with increasing responsibility over time.
- Works collaboratively across functions. Trains junior members of team as needed.
- A Ph.D. degree or equivalent in scientific discipline such as biology, chemistry, or pharmacology, is required.
- A minimum of five years experience conducting discovery research or related laboratory research. Advanced knowledge of biochemistry, enzymology, enzyme kinetics and thermodynamics, protein chemistry or other areas of math-intensive quantitative biology is highly desired.
- The ability to work independently, and simultaneously handle multiple projects.
- Demonstrated ability to work in an interactive team, excellent verbal and written communication skills, strong organizational skills.
Qualified motivated individuals should submit their CV, in addition to the names, e-mail addresses, and telephone numbers of three references to Dr. Eduard Sergienko, Director, Assay Development, via the Apply button below. Please cc: jcolomb@SBPdiscovery.org.
One fully funded postdoctoral position is available to study the role of autophagy adaptors in the control of the transcriptional activity of key mediators of stromal function in cancer. The project is based on our recent publication in Cancer Cell (Duran et al., 2016) and will use mouse models and cell based studies and the interrogation of human cancer samples. This is part of an ongoing collaboration between the laboratories of Jorge Moscat and Maria T. Diaz-Meco.
These laboratories are part of the Cancer Metabolism and Signaling Networks Program, an essential piece of the vibrant Sanford Burnham Prebys NCI-designated Cancer Center.
Our goal is to unravel the mechanistic crosstalk between stromal, immune, and tumor cells, to identify potential new targets for innovative cancer therapies. Additional publications by our labs describing ongoing studies in this area have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cell (2009, 2011, 2013), Cell Reports (2015, 2016), and Cancer Cell (2008, 2014, 2016).
We are looking for highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in studies related to transcriptional activity and epigenetics. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in this area.
Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references via the Apply button below (cc: Ms. Sarah Forte at sforte@SBPdiscovery.org)
The position is available starting immediately, and offers a very competitive health and retirement package.
A Postdoctoral Associate position is available to study non-coding RNAs (long noncoding RNA and microRNAs) regulation in prostate and skin cancer. Several putative oncogenic and tumor suppressor non-coding RNAs have been identified in our laboratory and we will characterize these through in-vitro and in-vivo functional and analytical genomics studies.
The prospective candidate will continue this study at the Lake Nona site of SBP located in Orlando, Florida.
The Ph.D. and/or M.D. Candidate must have a strong background in at least one of the following areas: tumor biology, cell biology, molecular biology, and/or transcriptional/post-transcriptional gene regulation/bioinformatics. Interested and qualified candidates should submit their CV, cover letter and list of references to Ms. Debbie McFadden via the Apply button below.
A Post-Doctoral Associate position is available in Dr. Rastinejad’s laboratory at the Sanford Burnham Prebys Medical Discovery Institute, in Lake Nona, Florida. This position provides an exceptional opportunity to enhance the candidate’s past training in X-ray crystallography, biochemistry, molecular biology and/or cell biology. The research training will emphasize protein expression through a variety of innovative methods, biochemical characterization of pure proteins, their crystallization and structure determination through modern macromolecular X-ray crystallography/diffraction methods. Selected candidate will additionally become exposed to high throughput drug-screening efforts in which the laboratory collaborates wit the Conrad-Prebys Center for Chemical Genomics within the same Institute.
The transcription factors to be studied are nuclear hormone receptors and mammalian bHLH-PAS proteins. Recent studies within Dr. Rastinejad’s laboratory have led to breakthroughs in the structural visualization of multi-domain transcription factors in a variety of functionally revealing complexes that include bound DNA, small-molecule ligands and coregulators. The new projects will involve intensive protein biochemistry, crystal growth and structure calculation and refinement based on X-ray diffraction data. The high-throughput screens will also be integrated throughout the structural biology training program, with the goal of identifying potent small-molecules that act as activators and inhibitors of transcription factors.
Requires a Ph.D. degree in Biology, Biochemistry or related field. Candidates who have strong research experience in X-ray crystallography, protein purification and biochemical binding studies, molecular biology, and/or cell-biology are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment. Interested candidates should apply with full CV, statement of research interests and list of references via the Apply button below.
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Marcus Kaul in projects investigating i) cellular and molecular mechanisms of host-pathogen interaction that lead to neuroinflammation and degeneration and ii) innate neuroprotective factors. A major focus is the neurotoxicity and brain injury associated with HIV-1 infection. The positions will be integral parts of studies dissecting molecular mechanisms of inflammatory and innate immune signaling pathways in macrophages and neural cell types using in vitro and in vivo models. The projects will combine molecular, cellular, biochemical as well as bioinformatics-based approaches, including NextGen Sequencing, RNAi, ASO, knockout and transgenic mouse models, etc. The positions are supported by NIH funding.
Highly motivated candidates who recently obtained a Ph.D. and/or M.D. degree, with a strong background either in neurobiology or inflammation, innate immunology, molecular biology and virology and biochemistry are encouraged to apply. Experience with transgenic and knockout or humanized mouse models and cellular signaling is a plus. Candidates must have good communication skills, and should be able to work independently in a highly interactive and collaborative scientific environment. Successful candidates will have a solid publication record in peer-reviewed journals.
Interested individuals should send their curriculum vitae, a brief description of their scientific background and interests, and the names of three references via the Apply button below.
The NCI-Designated Cancer Center of Sanford Burnham Prebys Medical Discovery Institute located in La Jolla, CA, is recruiting Postdoctoral Fellows to study cancer cell biology.
The Commisso Lab is focused on biological discoveries that have the potential to lead to novel therapeutic strategies for cancer. Of particular interest to our laboratory are Ras-driven cancers, such as tumors of the pancreas, colon and lung, which are extremely aggressive and are in urgent need of new and innovative therapies. The biological process that we study in the lab is called macropinocytosis, a fluid-phase form of bulk endocytic uptake, which we have linked to cancer cell metabolism in Ras-mutated tumors.
We are seeking highly motivated individuals to join our research team. The successful candidates will be active participants in a vibrant, collaborative atmosphere. The candidates will design and implement experiments using a variety of techniques such as cell culture, cell biology, molecular biology, and animal tumor models to help understand cancer cell dependencies at the molecular level. The main goal is to identify and develop novel therapeutic targets and to discover therapeutic agents to treat Ras-driven cancers.
Experimental bench science is an essential requirement, as well as the ability to present and discuss data. A research background in cancer biology, cell biology, or cell signaling is required and prior experience with mouse models and microscopy is preferred.
Candidates must have a Ph.D. degree and demonstrate the ability to successfully spearhead a research project by having first author publications in reputable and high impact journals (published, submitted or soon to be submitted).
Interested applicants should submit a cover letter and a CV. The last page of the CV should include the contact information (e-mail address and phone number) for three references. The PDF files should be emailed to Dr. Cosimo Commisso via the Apply button below.
Postdoctoral position in Eph receptor cancer biology.
A postdoctoral position is available to study the dual signaling mechanisms of Eph receptors in tumor promotion and tumor suppression, and the regulatory role of serine/threonine phosphorylation in Eph receptor function. The project will combine molecular, cellular, biochemical and proteomics approaches and in vivo mouse cancer models, and take advantage of interdisciplinary collaborations.
The Pasquale laboratory is part of the NCI-Designated Cancer Center and has a longstanding track record in studying the Eph family of receptor tyrosine kinases. Current research in the laboratory focuses on elucidating Eph receptor signaling pathways relevant to cancer biology, characterizing the effects of Eph receptor cancer mutations, and developing new Eph receptor-targeting agents for cancer imaging/treatment and against neurodegenerative diseases.
We are looking for a highly motivated, detail oriented and collaborative individual with a PhD or MD degree and a strong record of research productivity demonstrated through peer-reviewed publications. A background in molecular and cell biology and prior experience in signal transduction research are preferred. Interested applicants should submit a single PDF file that includes their CV, a brief description of research accomplishments, interests and career goals, and contact information of at least three references via the Apply button below.
2 Postdoctoral Associate Positions Open
Applications are invited from ambitious, independent and motivated candidates to work with Professor Peter D. Adams to investigate the epigenetics of aging and cancer. Prof. Adams is opening a lab at Sanford-Burnham-Prebys Medical Discovery Institute in late 2016. Specific projects in the lab range from development of novel epigenetic therapies to combat cancer (for example, epigenetic therapies to synergize with immune therapies), to epigenetic mechanisms of control of cellular senescence and aging, particularly those events that pre-dispose to cancer. A long-term goal of the lab is to develop epigenetic-based therapies that can prevent age-associated events that predispose to cancer, with a view to cancer chemoprevention.
The project will employ state-of-the-art molecular and cellular biology approaches, including ChIP-seq, RNA-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level; high throughput chemical and RNAi/CRISPR phenotypic screens; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR technology. In addition, we routinely employ sophisticated mouse models and human tissues.
The lab strives to be highly collaborative with other labs in San Diego, the US and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists and clinical oncologists. San Diego is an outstanding scientific environment and a fabulous place to live.
Candidates should have, or be working towards, a PhD or equivalent degree in a biological science. Expertise in an aspect of cell and/or molecular biology and/or animal models is essential. The lab has dedicated computational biology support for data analysis, so computational expertise is an advantage, but not essential. Successful applicants will be able to learn computational approaches for analysis of large datasets, a big advantage in a competitive job market.
Interested candidates should send an email with a summary of achievements and research interests, updated CV and contact information for 3 letters of reference to Dr. Peter Adams (email@example.com).
Please visit https://chromatin.wordpress.com for additional information.
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.
Sanford Burnham Prebys Medical Discovery Institute will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information.
A postdoctoral position is available with a flexible start date in the field of epigenetics in the Deshpande Lab at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla, California. SBP is known for its world-class capabilities in stem cell research and drug discovery technologies and is an NCI-designated Cancer Center. SBP is located on the scenic Torrey Pines Mesa and has collaborative ties to several adjacent world-class research institutions such as the Salk Institute, Scripps and the University of California San Diego as well as several leading pharmaceutical companies.
The Deshpande Lab is interested in cancer epigenetics with a core focus on hematological malignancies using mouse models. The lab also has a strong interest in normal hematopoietic stem cell biology. The candidate will be involved in the study of normal and cancerous stem cells using genomic, epigenomic and biochemical methods, high-throughput small molecule inhibitor screens and CRISPR-Cas9 mediated genome editing.
Highly motivated candidates with a recent Ph.D. in Cell Biology, Molecular biology, Genetics or relevant fields are encouraged to apply. Experience and expertise in cell and molecular biology (multi-parameter flow cytometry, chromatin immunoprecipitation, cell culture) and/or mouse models of hematopoiesis is highly desired. Basic knowledge of computational data analysis is a big plus but not a must. We are seeking collaborative individuals who are detail oriented, with excellent communication and data organization skills. Candidates must have a demonstrated ability to successfully spearhead a research project as evidenced by first author publications in reputable and high impact journals (published or submitted).
Interested candidates should send an email with a summary of achievements and research interests, updated CV and contact information for three letters of reference to Dr. Ani Deshpande the Apply button below.
The NCI-designated Cancer Center at SBP seeks junior, mid-career, and senior faculty to lead cutting-edge research programs in Cancer Immunology and Immunotherapy. Areas of interest include: anti-tumor immunity, tumor-promoting inflammatory cells and their products, immune recognition of tumor-specific antigens, and understanding the immunomodulatory effects of current and prospective cancer treatments. The SBP Cancer Center provides state-of-the-art laboratories and shared resources supported by a collaborative work environment.
The Faculty positions require a Ph.D. or M.D./Ph.D. and an outstanding record of publications and research accomplishments relevant to the focus areas. Chosen candidates are expected to establish well-supported, rigorous and competitive research programs based on fundamental mechanisms that can address unmet clinical needs.
To apply for consideration:
Interested applicants should send their CV, together with a cover letter, a short summary of past accomplishments, an outline of future research plans and, for assistant professor candidates, the contact information for 3-4 references to facultyrecruiting@SBPdiscovery.org. All application materials should be sent as a single PDF file with code #cc1115 referenced in the subject line.