Current Postdoctoral Training Opportunities

Current Postdoctoral Training Opportunities

Tumor Initiation and Maintenance

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Charles Spruck, Ph.D.
Research Description
A Postdoctoral position is available to work on various projects that will explore the molecular regulations of cell division control and define how alterations of these processes contribute to cancer development and progression. An emphasis of these projects will be the ubiquitin proteasome system (UPS) and the role of protein destruction in cancer.
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the fields of DNA damage response and ubiquitin-dependent proteolysis are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Charles Spruck at cspruck@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Jing Crystal Zhao, Ph.D.
Postdoctoral Associates
We seek a highly motivated postdoctoral fellow to study the roles of RNA modification in stem cell biology and cancer development. mRNA and noncoding RNA modification, particularly methylation at the N6 position of adenosine (N6-methyladenosine), has emerged as an important research area in epigenetics and RNA biology. My lab identified a protein complex that governs N6-methyladenosine formation. We found such modification shortens the half-life of mRNAs, including developmental regulators, in mouse embryonic stem cells. Currently, we are digging deeper into the molecular mechanisms through which m6A regulates RNA activity, using a combination of biochemistry, cell biology, and high throughout sequencing technologies. Please refer to our recent publication for further information (Nature Cell Biology 16 (2): 191-8, Feb. 2014).  This position is expected to start in May 2015. Please also find the job posting online from naturejobs.
Requirements
Ph.D. and/or M.D. candidate with a background in biochemistry, molecular biology, cell biology, and/or animal models are encouraged to apply. Interested applicants should submit a CV, 3 reference letters, and a cover letter to czhao@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Elena Pasquale, Ph.D.
Research Description
A postdoctoral position is available in a leading laboratory with a longstanding successful track record in studying the Eph family of receptor tyrosine kinases. Our current research focuses on elucidating the dual signaling mechanisms of Eph receptors in tumor promotion and tumor suppression, characterizing Eph receptor cancer mutations, and developing new Eph receptor-targeting agents for cancer imaging/treatment and against neurodegenerative diseases. Projects involve biochemistry and cell biology approaches, phage display, in vivo mouse cancer models, and interdisciplinary collaborations.
Requirements
We are looking for a highly motivated, independent and collaborative individual with a recent (within the last 3 years) PhD or MD/PhD and demonstrated productivity through peer-reviewed publications, including at least one first-author publication. A strong background in molecular and cell biology and prior experience in signal transduction research are preferred but not required. Interested applicants should submit a single PDF file that includes their CV, a brief description of research accomplishments, interests and career goals, and contact information of at least three references to: Dr. Elena Pasquale at elenap@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Duties and Responsibilities
Post-doctoral research in the epigenetic regulation of normal and leukemic stem cells:
A postdoctoral position is available with a flexible start date in the field of epigenetics in the Deshpande Lab at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla, California. SBP is known for its world-class capabilities in stem cell research and drug discovery technologies and is an NCI-designated Cancer Center. SBP is located on the scenic Torrey Pines Mesa and has collaborative ties to several adjacent world-class research institutions such as the Salk Institute, Scripps and the University of California San Diego as well as several leading pharmaceutical companies.
The Deshpande Lab is interested in cancer epigenetics with a core focus on hematological malignancies using mouse models. The lab also has a strong interest in normal hematopoietic stem cell biology. The candidate will be involved in the study of normal and cancerous stem cells using genomic, epigenomic and biochemical methods, high-throughput small molecule inhibitor screens and CRISPR-Cas9 mediated genome editing.
Requirements
Highly motivated candidates with a recent Ph.D. in Cell Biology, Molecular biology, Genetics or relevant fields are encouraged to apply. Experience and expertise in cell and molecular biology (multi-parameter flow cytometry, chromatin immunoprecipitation, cell culture) and/or mouse models of hematopoiesis is highly desired. Basic knowledge of computational data analysis is a big plus but not a must. We are seeking collaborative individuals who are detail oriented, with excellent communication and data organization skills. Candidates must have a demonstrated ability to successfully spearhead a research project as evidenced by first author publications in reputable and high impact journals (published or submitted).
 
Interested candidates should send an email with a summary of achievements and research interests, updated CV and contact information for 3 letters of reference to Dr. Ani Deshpande (adeshpande@SBPdiscovery.org).
 
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Duties and Responsibilities
A Postdoctoral position is available to work on various projects that will explore the molecular regulation of cell cycle control and cell fate in pancreatic cancer. Specifically, we will define how signaling through bHLH proteins alters processes which contribute to cancer development and progression. An emphasis of these projects will be on reprogramming pancreatic cancer to restore the acinar transcriptional program through E47.
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the field of cancer/transcriptional regulation/ bioinformatics are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Pamela Itkin-Ansari at pitkin@sbpdiscovery.org.

Cancer Metabolism and Signaling Networks

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Cosimo Commisso, Ph.D.

Research Description
The Cancer Metabolism and Signaling Networks Program of Sanford Burnham Prebys Medical Discovery Institute located in La Jolla, CA, is recruiting a Postdoctoral Fellow to study cancer cell biology and tumor metabolism.

The Commisso Lab (www.commissolab.com) is focused on biological discoveries that have the potential to lead to novel therapeutic strategies for cancer. Of particular interest to our laboratory are Ras-driven cancers, such as tumors of the pancreas, colon and lung, which are extremely aggressive and are in urgent need of new and innovative therapies. The biological process that we study in the lab is called macropinocytosis, a fluid-phase form of bulk endocytic uptake, which we have linked to cancer cell metabolism in Ras-mutated tumors.

We are seeking a highly motivated individual to join our research team. The successful candidate will be an active participant in a vibrant, collaborative atmosphere. The candidate will design and implement experiments using a variety of techniques such as cell culture, cell biology, molecular biology, and animal tumor models to help understand cancer cell metabolic dependencies at the molecular level. The main goal is to identify and develop novel therapeutic targets and to discover therapeutic agents to treat Ras-driven cancers.

Requirements
Experimental bench science is an essential requirement, as well as the ability to present and discuss data. A research background in cancer biology, cell biology, biochemistry or developmental biology is required and prior experience with mouse models, cell signaling, and/or microscopy is preferred.

Candidates must have a Ph.D. degree and demonstrate the ability to successfully spearhead a research project by having first author publications in reputable and high impact journals (published or submitted).

Interested applicants should submit a cover letter and a CV. The last page of the CV should include the contact information (e-mail address and phone number) for three references. The PDF files should be emailed to Dr. Cosimo Commisso at ccommisso@sbpdiscovery.org.

Positions are available starting immediately.

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
One fully funded postdoctoral position in the laboratory of Dr. Jorge Moscat in La Jolla, California, is available to study the role of autophagy adaptors and substrates in the metabolic control of the tumor microenvironment in hepatocellular carcinomas.
Our goal is to unravel the crosstalks between myofibroblasts, immune cells, and the liver parenchyma, to identify potential new targets for innovative cancer therapies. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).
 
For more information about the Moscat lab and the work we are doing, please visit sbpdiscovery.org/Talent/Pages/JorgeMoscat.aspx
Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism will be a plus. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sbpdiscovery.org
 
The position is available starting immediately.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Email Contact
Dr. Jorge Moscat jmoscat@sbpdiscovery.org
Dr. Maria T. Diaz-Meco mdmeco@sbpdiscovery.org
Research Description
Two postdoctoral positions are immediately available in the laboratories of Dr. Jorge Moscat and Dr. Maria Diaz-Meco in La Jolla, California, to study the role of the tumor microenvironment and cancer metabolism and its impact on liver and prostate cancer.
 
The laboratories are part of the vibrant Sanford Burnham Prebys NCI-designated Cancer Center (http://www.sbpdiscovery.org/research/centers/cancer/Pages/Home.aspx).
 
Our goal is to unravel the crosstalks between stroma, immune cells and cancer cells to identify potential new therapeutic targets for innovative cancer treatment. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).
 
For more information about the Moscat and Diaz-Meco labs and the work we are doing, please visit http://www.sbpdiscovery.org/Talent/Pages/JorgeMoscat.aspx and http://www.sbpdiscovery.org/Talent/Pages/MariaDiaz-Meco.aspx
Requirements
We are seeking highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism is a plus.
 
Interested applicants should submit a single PDF file containing CV; a brief description of research accomplishments, interests, and career goals; and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sbpdiscovery.org and Dr. Maria T. Diaz-Meco at mdmeco@sbpdiscovery.org.

Tumor Microenvironment and Cancer Immunology

La Jolla, CA
Postdoctoral Training Opportunity
Angiogenesis/Tumor Biology
Principal Investigator
William Stallcup, Ph.D.
Research Description
A postdoctoral position is available to study the function of the NG2 proteoglycan in both normal and tumor vascularization, building on the existing knowledge concerning NG2 participation in pericyte/endothelial cell interaction. A primary focus will be the investigation of NG2 function in mammary tumorigenesis, using both cell culture and animal models.
Requirements
Experience with relevant models, especially the use of histology and immunocytological imaging to study vivo mammary development and tumor progression, will be especially valuable. Expertise in areas such as cell biology, molecular biology, and biochemistry is also desirable. Candidates must have either a Ph.D. or M.D. and a publication record in one or more of the relevant areas. Interested applicants should submit a copy of their CV, and contact information (email address and phone number) of three references to: Dr. Bill Stallcup at stallcup@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral position in cancer metabolism
Principal Investigator
Research Description
A postdoctoral position is available to study metabolic regulation of B lymphocyte differentiation and transformation in Dr. Robert Rickert’s laboratory at Sanford Burnham Prebys Medical Discovery Institute (SBP) (www.rickertlab.org). Projects focus on the impact of microenvironmental factors and nutrient stress on B cell fate, and the identification of downstream signaling nodes that may be of critical importance in B lymphoma progression. 
Requirements
We are looking for a highly motivated and enthusiastic individual with a strong background in metabolic biochemistry and a desire to apply this knowledge to B lymphocyte biology and lymphomagenesis. The position is available starting immediately and salary is commensurate with experience. Applicants must have a Ph.D. or M.D. and a strong record of research productivity.
 
Interested applicants should submit a CV, a brief description of research accomplishments, interests, career goals, as well as contact information (e-mail address and phone number) of three references to robert@SBPdiscovery.org
 

Degenerative Diseases

La Jolla, CA
Postdoctoral Training Opportunity
Cell and Molecular Biology of Alzheimer's Disease
Principal Investigator
Huaxi Xu, Ph.D.
Email Contact
xuh@sbpdiscovery.org
Research Description
A Postdoctoral position is available to study molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease. Our research projects involve proteolytic processing and trafficking of beta-amyloid precursor protein, regulation of beta-amyloid generation and tau phosphorylation, and identification of novel genes and genetic pathways affecting beta-amyloid metabolism.
Requirements
Candidates must have a Ph.D. Outstanding candidates with expertise in cell and molecular biology are sought. Applicants with recent doctoral degrees should send their curriculum vitae contact information (email address and phone number) of three references to: Dr. Huaxi Xu at xuh@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Email Contact
Dr. Randal Kaufman c/o Taryn Goode tgoode@sbpdiscovery.org
Research Description
The laboratory of Dr. Randal J. Kaufman at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California has an opening for a Postdoctoral Associate to work on a project studying Hepatocellular carcinoma (HCC). HCC is the fifth most common malignancy worldwide and the third leading cause of cancer mortality, which usually occurs in patients with non-alcoholic steatohepatitis (NASH). We have developed murine models that closely mimic the process from NASH to HCC in humans, in which endoplasmic reticulum stress (ER stress) and the unfolded protein response (UPR) play essential roles. We propose to exploit these unique models to further dissect the mechanisms by which ER stress and UPR signaling in both tumor and tumor microenviroment promotes progression of NASH and HCC in mice and humans.
Our research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum. Of most significance are recent discoveries regarding how protein misfolding impacts liver failure and development of non-alcoholic steatohepatitis and eventually hepatocellular carcinoma.  The lab has unique mouse models to answer questions that are not possible anywhere else in the world. Technologies will include liver physiology/pathology, especially lipid metabolism and inflammation. The lab uses sophisticated technologies including mRNA-Seq, high throughput small molecule/siRNA screening, mass spectrometry, electron microscopy, flow cytometry, and the most advanced methods of manipulating the murine genome.  The position requires working with mice, isolating liver for RNA, protein and lipid analysis, isolation/characterization/transplantation of primary hepatocytes and isolation/characterization of immune cells.
Requirements
Candidates for this position must have a Ph.D. or M.D. The preferred candidate should have a strong background in molecular and cellular biology, and physiology.  A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with mice is required.  A background in tumor and/or tumor immunology is preferred.
 
This is a truly unique position to work on a high profile project that will have impact on human medical care.  Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sbpdiscovery.org.

Relevant Publications
Nakagawa, et al. (2014) ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26(3): 331-343.

Han et al. (2013) Endoplasmic reticulum (ER) stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biol. 15(5): 481-90. PMC3692270.

Wang et al. (2012) IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metabolism 16(4): 473-86. PMC3569089

Immunity and Pathogenesis

La Jolla, CA
Postdoctoral Training Opportunity
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of innate immunology/pattern recognition receptor responses and virus-host interactions. This position will be focused on defining molecular mechanisms of certain innate immune signaling pathways in the context of pathogen infection using systems-based approaches. Studies will integrate both large-scale technologies (RNAi, AP-MS, NextGen Sequencing, etc.) and more traditional cell & molecular biology and biochemistry-based approaches. Positions are supported by NIH funding.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in immunology, virology, cell biology, and biochemistry are encouraged to apply. In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment. Successful candidates will have a strong publication record in peer-reviewed journals.

Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to: Crystal Herndon at cherndon@sbpdiscovery.org. Please visit www.chandalab.org for additional information.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Bas Baaten, Ph.D.

Research Description
A postdoctoral position is immediately available in the Immunity and Pathogenesis program at the Sanford Burnham Prebys Medical Discovery Institute to study host-pathogen interactions at mucosal surfaces. The selected candidate will lead our ongoing efforts to identify the mechanisms that govern the balance between immunity and pathology at the nasal and pulmonary mucosa following viral infection. Current projects are focused on exploring the mechanisms underlying defective T cell immunity in the aged following influenza virus infection. He/she will use an array of cellular and molecular approaches to evaluate immune function in mouse models and human cells and is expected to formulate, execute, and communicate research projects. 

Requirements
Highly motivated individuals with a strong background in cellular and molecular immunology and who recently obtained a Ph.D. are strongly encouraged to apply.  Previous experience with mouse models is highly desired. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.

Interested applicants should submit a CV, contact information (e-mail address and phone number) of three references, and a brief description of research accomplishments, interests, and career goals to bbaaten@sbpdiscovery.org.

La Jolla, CA
Postdoctoral Training Opportunities
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
Multiple postdoctoral positions are immediately available in SBP Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda.  Positions will focus on generating a systems-level understanding of immune responses pathways including TLRs, cGAS, CD40 and Fc-mediated signaling.  Prospective candidates will play an important role in elucidating novel factors involved in the interplay between host innate immune factors and their implication in inflammatory and autoimmune disease.  Aspects of certain projects will involve collaborations with Pharma R&D teams.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in innate immune signaling are encouraged to apply.   The ideal candidate will have a deep understanding of the innate immune system including TLR, NLR, and RLR signaling as well as pathways induced in  myeloid & B cells.  In addition, experience in virology, cell biology, and biochemistry and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.  Successful candidates will have a strong publication record in peer-reviewed journals. 

Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sbpdiscovery.org. Please visit www.chandalab.org for additional information.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position in B cell biology/autoimmunity
Principal Investigator
Email Contact
 
Research Description
A postdoctoral position is available to study B lymphocyte biology and autoimmunity in Dr. Robert Rickert’s laboratory at Sanford Burnham Prebys Medical Discovery Institute (SBP) (www.rickertlab.org). Projects focus on signal transduction mechanisms that regulate B cell tolerance versus activation in response to systemic or gut-associated self-antigens. To investigate these topics, we employ cutting edge techniques that include: imaging cytometry, flow cytometry, mass cytometry (CyTOF), intravital imaging, single cell transcriptomics, conditional gene targeting, genome editing and retrogenics. 
Requirements
We are looking for a highly motivated and enthusiastic individual with a strong background in immunology and experience working with mouse models. The position is available starting immediately and salary is commensurate with experience.  Applicants must have a Ph.D. or M.D. and a strong record of research productivity.
 
Interested applicants should submit a CV, a brief description of research accomplishments, interests, career goals, as well as contact information (e-mail address and phone number) of three references to robert@SBPdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Host-Pathogen Interactions and Neuroinflammation
Principal Investigator
Email Contact
Research Description
Two postdoctoral positions are immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Marcus Kaul in projects investigating i) cellular and molecular mechanisms of host-pathogen interaction that lead to neuroinflammation and degeneration and ii) innate neuroprotective factors. A major focus is the neurotoxicity and brain injury associated with HIV-1 infection. The positions will be integral parts of studies dissecting molecular mechanisms of inflammatory and innate immune signaling pathways in macrophages and neural cell types using in vitro and in vivo models. The projects will combine molecular, cellular, biochemical as well as bioinformatics-based approaches, including NextGen Sequencing, RNAi, ASO, knockout and transgenic mouse models, etc. The positions are supported by NIH funding. 
Requirements
Highly motivated candidates who recently obtained a Ph.D. and/or M.D. degree, with a strong background either in neurobiology or inflammation, innate immunology, molecular biology and virology and biochemistry are encouraged to apply. Experience with transgenic and knockout or humanized mouse models and cellular signaling is a plus. Candidates must have good communication skills, and should be able to work independently in a highly interactive and collaborative scientific environment. Successful candidates will have a solid publication record in peer-reviewed journals.
 
Interested individuals should send their curriculum vitae, a brief description of their scientific background and interests, and the names of three references to mkaul@sbpdiscovery.org

Human Genetics

La Jolla, CA

Postdoctoral Training Opportunity

Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunities
Principal Investigator
Hudson Freeze, Ph.D.

Research Description
A postdoctoral position is immediately available at the Sanford Burnham Prebys Medical Discovery Institute to study NGLY1 mutations that cause a recently discovered human neurological disease of protein N-de-glycosylation. The pathological mechanism is unknown.
 
Our team combines cell biology, biochemistry, and human genetics in solve Congenital Disorders of Glycosylation (CDG) including NGLY1. Fundamental discoveries are aimed at translational applications that can benefit the patients.
 
The postdoc will drive the project to identify consequences of disrupted N-glycan cleavage from misfolded glycoproteins that are retro-translocated into the cytoplasm. Plans include a search for obligate substrates, alternate cleavage pathways, potential therapeutic molecules, and analysis of patient cells. Techniques include gene manipulation, glycan analysis, fluorescence methods, and proteomic analysis.

Close collaborations with other NGLY1 research laboratories, the NIH, and philanthropic organizations provide unique interactive opportunities for the candidate.
 
If interested in this challenging research opportunity in NGLY1, please read PMID: 24651605, PMID: 25900930, and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2

Requirements

  • Recent PhD or MD/PhD with strong motivation and background in  biochemistry, genetics, cellular & molecular biology
  • Publications in any 3 of the following: biochemistry, cell biology, glycobiology, ERAD or cytoplasmic protein degradation.
  • Excellent verbal/written communication skills in fluent English.
  • Independent self-starter, who thrives in a highly interactive, collaborative scientific environment.

How to Apply
Send a single PDF document that includes all of the following:

  • • Your current CV
  • • One-page letter outlining your background, specific interest in NGLY1, and how you would like to study it.
  • • Three recent reference contacts for this project

Email the PDF document to Dr. Hudson Freeze at azimmon@sbpdiscovery.org

Development, Aging, and Regeneration

La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Rolf Bodmer, Ph.D.
Email Contact
rolf@sbpdiscovery.org
Research Description
A Postdoctoral position is available for a candidate to study the genetic control of the heart, using primarily Drosophila as a model system. Possible projects using molecular-genetic, imaging and physiological techniques range from analysis of early cardiogenic genes to genes controlling heart function and cardiac aging to genes involved in left-right asymmetry.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Rolf Bodmer at rolf@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Development and Disease
Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Alexey Terskikh, Ph.D.
Research Description
A post-doctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, SBP, La Jolla, California. The position focuses on understanding the role of SoxB1 factors in in self-renewal and differentiation of normal and neoplastic neural stem cell. A candidate will undertake a comprehensive analysis of SoxB1 interactome and function combining the expression analysis, proteome, and chromatin binding assays. The long-term goal of this project is to identify novel genes and pathways as well as develop small molecules either enhancing adult hippocampal neurogenesis or inducing differentiation of cancer “stem cells."
Requirements
The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.

Interested candidates should contact the PI, Dr. Alexey Terskikh at Terskikh@sbpdiscovery.org.

Please send a detailed resume, summary of previous work, electronic reprints of recent publications, and names and contact information for three references.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
A post-doctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, SBP, La Jolla, California. The position focuses on the novel approaches to study epigenetics at a single cell level. A candidate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL), a novel platform developed in our laboratory. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells. A candidate will investigate the epigenetic heterogeneity at the single cell level (3D) during normal neurogenesis and in brain tumors. The long-term goal of this project is to identify unique epigenetic signatures that could classify normal cells in the body as well as neoplastic tumor cells and help their prospective isolation.

The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.

Interested candidates should contact Dr. Alexey Terskikh (Terskikh@sbpdiscovery.org).

Please send a detailed resume, summary of previous work, electronic reprints of recent publications, and names and contact information for three references.
La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Research Description
A Postdoctoral position is available for a candidate to study the genetics underlying heart function and disease, using primarily Drosophila as a model system. Possible projects include using molecular-genetics, imaging and physiological techniques to understand the roles of ion channels in heart function/disease,  genes contributing to cardiac aging and the role of metabolism in cardiac function/dysfunction.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Karen Ocorr at kocorr@sbpdiscovery.org.

Bioinformatics and Structural Biology

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Niels Volkmann, Ph.D.
Research Description
A postdoctoral position is immediately available in the laboratory of Dr. Niels Volkmann, Sanford Burnham Prebys Medical Discovery Institute (SBP), located on the Torrey Mesa in La Jolla, walking distance from Salk, Scripps, and UCSD (La Jolla, CA, USA).

Our research focuses on the development and application of approaches for structure determination of small and structurally heterogeneous macromolecules by cryo-EM (many of them helical) as well as for reconstruction and interpretation of cellular tomograms obtained by cryo-electron tomography. All work will be conducted in close collaboration with Dr. Dorit Hanein’s experimental cryo-EM group at SBP.
Requirements
The successful candidate should be highly motivated and have a PhD in structural biology, image processing or a related subject, good communication skills and a strong analytical mind. Preference will be given to experts in algorithm design and scientific computer programming with a proven interest in structural biology and to candidates who have excellent skills in experimental cryo-EM and application of structure determination approaches such as single-particle, helical, or tomographic reconstruction methods.

Candidates should send a CV, statement of research interest and focus, and provide the contact information for at least three professional references to Dr. Niels Volkmann, niels@sbpdiscovery.org.

Cardiovascular Metabolism

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Description
A position is available for a highly motivated postdoctoral associate with experience in molecular cell biology and physiology to perform studies in mouse models and in cell culture to understand the metabolic origins of disease. The predominant foci in the lab are centered on the inter-organelle, intercellular, and inter-organ metabolic and signaling mechanisms that predispose to and protect from the consequences of obesity, fatty liver disease, and heart failure. The laboratory environment is heavily collaborative and interdisciplinary. The trainee will be charged with experimental design, sample collection and preparation, metabolite analyses by a variety of techniques, data analysis and interpretation, manuscript preparation, and data presentation at national and international conferences.
 
A key analytical element of the lab includes metabolomics analyses in the context of biological systems labeled with stable isotope tracers. In collaboration with mass spectrometry specialists and NMR spectroscopists in the lab, the trainee will utilize analytical techniques such as multi-dimensional liquid chromatography-mass spectrometry (LC-MS) and NMR, coupled to informatic approaches to chemical feature identification, metabolic pathways analysis, and fluxomics to quantitate thousands of lipid species and metabolites in a high throughput manner to reveal the underlying mechanism(s) responsible for the changes of lipidome/metabolome under the selected pathological condition(s). The postdoc will facilitate and have the opportunity to learn and apply these techniques, analyses, and data interpretation.
 
SPECIFIC RESEARCH FOCUS: 
The primary research project will work on a translational and collaborative project among the Crawford and numerous other laboratories. The project will employ metabolomics and lipidomics approaches to study the altered metabolism by using mouse and human tissue samples to study heart failure and fatty liver disease in diabetes/obesity individuals/models and to identify the underlying molecular mechanism(s) responsible for the alterations under the selected pathological condition.

Requirements
Requires a doctoral degree in biology, biochemistry or related field. Candidates who have research experience in cell/molecular biology or biochemistry are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment. Trainees on career development trajectory toward an independent investigator track will be particularly competitive.

Interested candidates should apply with full CV, statement of research interests and list of references via LakenonaRecruitment@SBPdiscovery.org

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Email Contact
Description
We are seeking a talented, dynamic, and self-motivated Postdoctoral Research Associate with experience in molecular biology/biochemistry to train in Dr. Muthu Periasamy’s lab. A major focus of our research is to understand regulation of Calcium transport in muscle cells. We are studying the role of SERCA and its partners Sarcolipin and Phospholamban in myocyte Ca2+ homeostasis.  (Please read Maurya et al J. Biol. Chem.-2015 10840-9 , Sahoo etal J. Biol. Chem.-2013- 6881-9 , Sahoo et al J. Biol. Chem.-2013-6881-9 , Bal etal Nat.Med 2012 )The applicant will be expected to perform structure function studies to understand how binding of PLB and SLN affect SERCA mediated Ca2+ transport either in microsomes or in cardio myocytes.  Preference will be given to applicants who have background in protein biochemistry, structural biology, and myocyte Ca2+ dynamics. The candidate will be encouraged to work independently and become proficient in manuscript/grant-writing. There are opportunities to develop ideas, seek independent funding, and get promoted in rank.
Requirements
Requires a Ph.D. degree in Biological sciences. Candidates who have research experience in protein biochemistry , Ca2+ transport studies  , Ca2+ imaging /electrophysiology in cardiac myocytes  are strongly preferred. Ideal candidate must be motivated, have excellent written/oral communication skills, a strong desire and ability to work as a team in a collaborative environment.
Interested candidates should apply with full CV, statement of research interests, and list of references to itiu@SBPdiscovery.org

Integrative Metabolism

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Description
Postdoctoral Associate positions are available to study epigenetic patterns and regulation within adipose tissue depots utilizing genome-wide analyses; bioinformatics; and molecular and cellular mechanisms.

Required Experience
Candidates must have a Ph.D. and/or M.D. and must have a strong background in molecular skills associated with genome-wide protein binding (ChIP and ChIP-seq), including bioinformatics analysis (microarray, ChIP-seq, and/or RNA-seq).  In addition, applicants must have experience in the following technical areas: maintenance and manipulation of mouse genetic models, isolation of animal tissues, as well as molecular and cell biology skills.  Experience with liver or adipose tissue biology is preferred.  Interested applicants should submit a cover letter including research accomplishments and interests, CV, and names of at least 3 references to pphelan@sbpdiscovery.org

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate in Chemosensation and Metabolism/Diabetes
Principal Investigator
Research Description
A Postdoctoral Associate position is available in the Kyriazis lab to study the role of chemosensory receptors in metabolism using genetic mouse models and cellular/molecular mechanisms in an interdisciplinary research setting involving translational opportunities. Our group is investigating how extra-oral sweet taste receptors (STRs) sense acute and chronic changes in dietary and circulating nutrients to regulate metabolism (i.e. endocrine responses and substrate utilization) independent of nutrient metabolism. Particular emphasis is placed on understanding how STRs are regulated and contribute to the development of metabolic diseases, such as obesity and diabetes.
 
Training environment
The Kyriazis lab is part of the Integrative Metabolism Program (IMP) within the Center for Metabolic Origins of Disease (CMOD) at Sanford Burnham Prebys Medical Discovery Institute, Lake Nona. In addition, our group is a member of a multidisciplinary team of investigators (basic scientists, clinicians and surgeons) that specifically aims to decipher the role of chemosensory receptors in the gut and their role in metabolic disease by implementing direct bench-to-bedside approaches in collaboration with the Translational Research Institute for Metabolism and Diabetes (TRI-MD) at Florida Hospital. The postdoctoral associate will get ample training opportunities in molecular and integrative metabolism and exposure to state-of-the-art techniques (metabolomics, genomics, TIRF and calcium imaging, ex vivo transepithelial transport, animal metabolic phenotyping etc.). The training program also involves institute-wide postdoctoral seminars, career workshops and opportunities to interact with nationally recognized scientists in the area of metabolism.
 
For more information on the research, please follow the URLs:
Requirements
We seek highly committed and motivated candidates that have a Ph.D. and or M.D. with a strong background and technical skills in the following areas: mouse physiology including methods in cell-signaling, gene regulation and molecular/cell biology. Experience in endocrine physiology and signaling, fuel metabolism and expertise in islet, intestinal, or muscle biology are preferred. Interested applicants should submit a cover letter including research accomplishments and interests, CV and names of at least three (3) references to gkyriazis@sbpdiscovery.org
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate in X-Ray Crystallography of Transcription Factors
Principal Investigator
Job Description
A Post-Doctoral Associate position is available in Dr. Rastinejad’s laboratory at the Sanford Burnham Prebys Medical Discovery Institute, in Lake Nona, Florida.  This position provides an exceptional opportunity to enhance the candidate’s past training in X-ray crystallography, biochemistry, molecular biology and/or cell biology.  The research training will emphasize protein expression through a variety of innovative methods, biochemical characterization of pure proteins, their crystallization and structure determination through modern macromolecular X-ray crystallography/diffraction methods.  Selected candidate will additionally become exposed to high throughput drug-screening efforts in which the laboratory collaborates wit the Conrad-Prebys Center for Chemical Genomics within the same Institute.
 
The transcription factors to be studied are nuclear hormone receptors and mammalian bHLH-PAS proteins.  Recent studies within Dr. Rastinejad’s laboratory have led to breakthroughs in the structural visualization of multi-domain transcription factors in a variety of functionally revealing complexes that include bound DNA, small-molecule ligands and coregulators.  The new projects will involve intensive protein biochemistry, crystal growth and structure calculation and refinement based on X-ray diffraction data.  The high-throughput screens will also be integrated throughout the structural biology training program, with the goal of identifying potent small-molecules that act as activators and inhibitors of transcription factors.
Required Education & Experience
Requires a Ph.D. degree in Biology, Biochemistry or related field. Candidates who have strong research experience in X-ray crystallography, protein purification and biochemical binding studies, molecular biology, and/or cell-biology are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment.  Interested candidates should apply with full CV, statement of research interests and list of references via LakenonaRecruitment@SBPdiscovery.org
 
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability. We are committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law.  For additional information about your rights as an applicant, click HERE.
 
Sanford Burnham Prebys Medical Discovery Institute endeavors to make its careers page accessible to any and all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process, please contact James DiStefano, Director, Human Resources at accommodations@sbpdiscovery.org. This information is for accommodation requests only and cannot be used to inquire about the status of applications.

Genomic Control of Metabolism

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Description
A position is available for a highly motivated postdoctoral associate with experience in molecular cell biology and physiology to perform studies in mouse models and in cell culture to understand the metabolic origins of disease. The predominant foci in the lab are centered on the inter-organelle, intercellular, and inter-organ metabolic and signaling mechanisms that predispose to and protect from the consequences of obesity, fatty liver disease, and heart failure. The laboratory environment is heavily collaborative and interdisciplinary. The trainee will be charged with experimental design, sample collection and preparation, metabolite analyses by a variety of techniques, data analysis and interpretation, manuscript preparation, and data presentation at national and international conferences.
 
A key analytical element of the lab includes metabolomics analyses in the context of biological systems labeled with stable isotope tracers. In collaboration with mass spectrometry specialists and NMR spectroscopists in the lab, the trainee will utilize analytical techniques such as multi-dimensional liquid chromatography-mass spectrometry (LC-MS) and NMR, coupled to informatic approaches to chemical feature identification, metabolic pathways analysis, and fluxomics to quantitate thousands of lipid species and metabolites in a high throughput manner to reveal the underlying mechanism(s) responsible for the changes of lipidome/metabolome under the selected pathological condition(s). The postdoc will facilitate and have the opportunity to learn and apply these techniques, analyses, and data interpretation.
 
SPECIFIC RESEARCH FOCUS: 
The primary research project will work on a translational and collaborative project among the Crawford and numerous other laboratories. The project will employ metabolomics and lipidomics approaches to study the altered metabolism by using mouse and human tissue samples to study heart failure and fatty liver disease in diabetes/obesity individuals/models and to identify the underlying molecular mechanism(s) responsible for the alterations under the selected pathological condition.

Requirements
Requires a doctoral degree in biology, biochemistry or related field. Candidates who have research experience in cell/molecular biology or biochemistry are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment. Trainees on career development trajectory toward an independent investigator track will be particularly competitive.

Interested candidates should apply with full CV, statement of research interests and list of references via LakenonaRecruitment@SBPdiscovery.org

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Email Contact
Description
We are seeking a talented, dynamic, and self-motivated Postdoctoral Research Associate with experience in molecular biology/biochemistry to train in Dr. Muthu Periasamy’s lab. A major focus of our research is to understand regulation of Calcium transport in muscle cells. We are studying the role of SERCA and its partners Sarcolipin and Phospholamban in myocyte Ca2+ homeostasis.  (Please read Maurya et al J. Biol. Chem.-2015 10840-9 , Sahoo etal J. Biol. Chem.-2013- 6881-9 , Sahoo et al J. Biol. Chem.-2013-6881-9 , Bal etal Nat.Med 2012 )The applicant will be expected to perform structure function studies to understand how binding of PLB and SLN affect SERCA mediated Ca2+ transport either in microsomes or in cardio myocytes.  Preference will be given to applicants who have background in protein biochemistry, structural biology, and myocyte Ca2+ dynamics. The candidate will be encouraged to work independently and become proficient in manuscript/grant-writing. There are opportunities to develop ideas, seek independent funding, and get promoted in rank.
Requirements
Requires a Ph.D. degree in Biological sciences. Candidates who have research experience in protein biochemistry , Ca2+ transport studies  , Ca2+ imaging /electrophysiology in cardiac myocytes  are strongly preferred. Ideal candidate must be motivated, have excellent written/oral communication skills, a strong desire and ability to work as a team in a collaborative environment.
Interested candidates should apply with full CV, statement of research interests, and list of references to itiu@SBPdiscovery.org

Conrad Prebys Center for Chemical Genomics

There are no items to show in this view of the "Postdoc Opportunities" list.
Sign In Skip Navigation Links Skip navigation links
Benefits
Faculty & Leadership
Information for New Employees
Diversity