Current Postdoctoral Training Opportunities

Current Postdoctoral Training Opportunities

Tumor Initiation and Maintenance

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
Post-doctoral research in the epigenetic regulation of normal and leukemic stem cells:
A postdoctoral position is available with a flexible start date in the field of epigenetics in the Deshpande Lab at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla, California. SBP is known for its world-class capabilities in stem cell research and drug discovery technologies and is an NCI-designated Cancer Center. SBP is located on the scenic Torrey Pines Mesa and has collaborative ties to several adjacent world-class research institutions such as the Salk Institute, Scripps and the University of California San Diego as well as several leading pharmaceutical companies.
The Deshpande Lab is interested in cancer epigenetics with a core focus on hematological malignancies using mouse models. The lab also has a strong interest in normal hematopoietic stem cell biology. The candidate will be involved in the study of normal and cancerous stem cells using genomic, epigenomic and biochemical methods, high-throughput small molecule inhibitor screens and CRISPR-Cas9 mediated genome editing.
Requirements
Highly motivated candidates with a recent Ph.D. in Cell Biology, Molecular biology, Genetics or relevant fields are encouraged to apply. Experience and expertise in cell and molecular biology (multi-parameter flow cytometry, chromatin immunoprecipitation, cell culture) and/or mouse models of hematopoiesis is highly desired. Basic knowledge of computational data analysis is a big plus but not a must. We are seeking collaborative individuals who are detail oriented, with excellent communication and data organization skills. Candidates must have a demonstrated ability to successfully spearhead a research project as evidenced by first author publications in reputable and high impact journals (published or submitted).
 
Interested candidates should send an email with a summary of achievements and research interests, updated CV and contact information for 3 letters of reference to Dr. Ani Deshpande (adeshpande@SBPdiscovery.org).
 
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Peter D. Adams, PhD.
 
Research Description
Applications are invited from ambitious, independent and motivated candidates to work with Professor Peter D. Adams to investigate the epigenetics of aging and age-associated diseases, such as cancer. Specific projects range from development of novel epigenetic therapies to combat cancer (for example, epigenetic therapies to synergize with immune therapies), to mechanistic investigation of epigenetic control of cellular senescence and aging, particularly those events that pre-dispose to cancer. A long-term goal of the lab is to develop epigenetic-based therapies that can prevent age-associated events that predispose to cancer, with a view to cancer chemoprevention.
 
The project will employ state-of-the-art molecular and cellular biology approaches, including ChIP-seq, RNA-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR/Cas9 technology. In addition, we routinely employ sophisticated mouse models and human tissues.
 
The lab strives to be highly collaborative with other labs in San Diego, the US and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists and clinical oncologists.
Requirements
Candidates should have, or be working towards, a PhD or equivalent degree in a biological science. Expertise in some aspect of cell and/or molecular biology and/or animal models is essential. The Adams lab has dedicated computational biology support for data analysis, so computational expertise is an advantage, but not essential. Successful applicants will have opportunity to learn computational approaches for analysis of large datasets, a big advantage in the competitive job market.
 
Interested candidates should send an email with a summary of achievements and research interests, updated CV and contact information for 3 letters of reference to Dr. Peter Adams (p.adams@beatson.gla.ac.uk)
 
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Elena Pasquale, Ph.D.
Program
Tumor Initiation and Maintenance

Research Description
Postdoctoral position in Eph receptor cancer biology.
A postdoctoral position is available to study the dual signaling mechanisms of Eph receptors in tumor promotion and tumor suppression, and the regulatory role of serine/threonine phosphorylation in Eph receptor function. The project will combine molecular, cellular, biochemical and proteomics approaches and in vivo mouse cancer models, and take advantage of interdisciplinary collaborations.

The Pasquale laboratory is part of the NCI-Designated Cancer Center and has a longstanding track record in studying the Eph family of receptor tyrosine kinases. Current research in the laboratory focuses on elucidating Eph receptor signaling pathways relevant to cancer biology, characterizing the effects of Eph receptor cancer mutations, and developing new Eph receptor-targeting agents for cancer imaging/treatment and against neurodegenerative diseases.

Requirements
We are looking for a highly motivated, detail oriented and collaborative individual with a PhD or MD degree and a strong record of research productivity demonstrated through peer-reviewed publications. A background in molecular and cell biology and prior experience in signal transduction research are preferred. Interested applicants should submit a single PDF file that includes their CV, a brief description of research accomplishments, interests and career goals, and contact information of at least three references to Dr. Elena Pasquale (elenap@sbpdiscovery.org).

Cancer Metabolism and Signaling Networks

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
One fully funded postdoctoral position in the laboratory of Dr. Jorge Moscat in La Jolla, California, is available to study the role of autophagy adaptors and substrates in the metabolic control of the tumor microenvironment in hepatocellular carcinomas.
Our goal is to unravel the crosstalks between myofibroblasts, immune cells, and the liver parenchyma, to identify potential new targets for innovative cancer therapies. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).
 
For more information about the Moscat lab and the work we are doing, please visit sbpdiscovery.org/Talent/Pages/JorgeMoscat.aspx
Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism will be a plus. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sbpdiscovery.org
 
The position is available starting immediately.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
One postdoctoral position is available in the laboratory of Dr. Maria Diaz-Meco in La Jolla, California, to study the role of the tumor microenvironment and cancer metabolism and its impact on prostate cancer. 
 
The laboratory is part of the vibrant Sanford Burnham Prebys NCI-designated Cancer Center (http://www.sbpdiscovery.org/research/centers/cancer/Pages/Home.aspx)
 
Our goal is to unravel the crosstalks between stroma, immune cells and cancer cells to identify potential new therapeutic targets for innovative cancer treatment. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).
 
For more information about the Diaz-Meco lab and the work we are doing, please visit http://www.sbpdiscovery.org/Talent/Pages/MariaDiaz-Meco.aspx.
Requirements
We are seeking highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism is a plus.
 
Interested applicants should submit a single PDF file containing CV; a brief description of research accomplishments, interests, and career goals; and contact information (e-mail address and phone number) of three references to Dr. Maria T. Diaz-Meco at mdmeco@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
We are currently seeking highly motivated and independent postdocs to join the Emerling lab to investigate the role of the PI5P4K enzymes in cancer metabolism. Current work focuses on the requirement of the PI5P4K enzymes in breast cancer and autophagy using genetically engineered mouse models.
Requirements
Candidates should have a recent PhD or MD/PhD degree and experience in cancer metabolism and/or mouse tumor models. Additional experience in autophagy biology and cell signaling as well as with technologies including metabolomics is highly desirable.
To apply, please send your CV, description of past research and list of three referees to: bemerling@sbpdiscovery.org

Tumor Microenvironment and Cancer Immunology

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral position in cancer metabolism
Principal Investigator
Research Description
A postdoctoral position is available to study metabolic regulation of B lymphocyte differentiation and transformation in Dr. Robert Rickert’s laboratory at Sanford Burnham Prebys Medical Discovery Institute (SBP) (www.rickertlab.org). Projects focus on the impact of microenvironmental factors and nutrient stress on B cell fate, and the identification of downstream signaling nodes that may be of critical importance in B lymphoma progression. 
Requirements
We are looking for a highly motivated and enthusiastic individual with a strong background in metabolic biochemistry and a desire to apply this knowledge to B lymphocyte biology and lymphomagenesis. The position is available starting immediately and salary is commensurate with experience. Applicants must have a Ph.D. or M.D. and a strong record of research productivity.
 
Interested applicants should submit a CV, a brief description of research accomplishments, interests, career goals, as well as contact information (e-mail address and phone number) of three references to robert@SBPdiscovery.org
 
Santa Barbara, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
A postdoctoral position is available in the laboratory of Dr. Jamey Marth to study infectious diseases and the complication of sepsis.  The lab is focused upon how protein glycosylation and glycoprotein remodeling control the aging and turnover of secreted proteins in modulating the coagulopathy and inflammation of microbial sepsis.  The project will include both mouse models and human patients involving collaborations between scientists and clinicians. 
Requirements
Candidates must have a Ph.D. or M.D. in Molecular Biology, Microbiology, or Clinical Medicine. Ideal candidates would have experience in infectious disease research, inflammatory biology, protein biochemistry, and proteomics.  Training will be provided as necessary to include glycan linkage analyses.
 
Interested candidates should send their CV and names of three personal references by email or regular mail to: Katelyn Jerlinga, 9625 MCDB, University of California, Santa Barbara, CA 93106-9625. E-mail: kjerlinga@sbpdiscovery.org.

Degenerative Diseases

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position for Diabetes Research
Principal Investigator
Research Description
The laboratory of Dr. Randal Kaufman at Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California has an opening for a Postdoctoral Associate. The lab’s research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum.
Type 2 diabetes results when beta cells are pressured to produce elevated levels of insulin to compensate for systemic insulin resistance.  As a consequence, protein-folding events within the endoplasmic reticulum are disturbed and unfolded proteins accumulate that lead to beta cell death.  The successful candidate will study insulin synthesis and secretion in beta cells from mice that are genetically engineered to alter protein-folding capacity in the ER.

Requirements
Candidates for this position must have a PhD or MD.  Technical skills will include molecular and cellular biology, protein biochemistry, and murine genetics. A strong publication record, excellent communication skills and ability to work in a team are essential. A background in beta cell biology is preferred.  Experience in working with mice is preferred. This is a unique position to work on a high profile project that will have a direct impact on human medical care.

 

Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sbpdiscovery.org.

Immunity and Pathogenesis

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Bas Baaten, Ph.D.

Research Description
A postdoctoral position is immediately available in the immunity and pathogenesis program at the Sanford Burnham Prebys Medical Discovery Institute to study host-pathogen interactions at mucosal surfaces. The selected candidate will lead our ongoing efforts to identify the mechanisms that govern the balance between immunity and pathology at the nasal and pulmonary mucosa following viral infection. Current projects are focused on exploring the mechanisms underlying defective T cell immunity in the aged following influenza virus infection. He/she will use an array of cellular and molecular approaches to evaluate immune function in mouse models and human cells and is expected to formulate, execute, and communicate research projects. 

Requirements
Highly motivated individuals with a strong background in cellular and molecular immunology and who recently obtained a Ph.D. are strongly encouraged to apply.  Previous experience with mouse models is highly desired. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.

Interested applicants should submit a CV, contact information (e-mail address and phone number) of three references, and a brief description of research accomplishments, interests, and career goals to bbaaten@sbpdiscovery.org.

La Jolla, CA
Postdoctoral Training Opportunities
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
Multiple postdoctoral positions are immediately available at Sanford Burnham Prebys Medical Discovery Institute in the laboratory of Dr. Sumit K. Chanda (La Jolla, CA).  Positions will focus on generating both systems-level and mechanistic understanding of immune response pathways including TLRs, NLRs, cGAS, CD40 and Fc-mediated signaling, host-pathogen interactions of RNA and DNA viruses, including HIV-1, IAV, DENV, WNV, CHICKV, EBOV, ZIKV, and HHV8. Studies will place an emphasis on translating basic research discoveries into pre-clinical concepts.  Specifically, prospective candidates will play an important role in elucidating novel factors involved in the interplay between virus and host innate immune factors, and understanding their therapeutic implications in inflammatory, autoimmune, infectious disease, and cancer.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in immune signaling or molecular virology are encouraged to apply.   The ideal candidate will have a deep understanding of the innate immune system including TLR, NLR, and RLR signaling, as well as additional immune pathways induced in myeloid & lymphoid cells, and/or strong experience in virology, cell biology and biochemistry. An understanding and ability to apply systems level technologies, including high throughput genetics, proteomics, NGS, metabolomics, and chemical biology, as well as associated statistical techniques towards the analysis of large data sets, are a plus. Candidates must have excellent communication skills, and should be able to work both independently and in a collaborative scientific environment.  Only candidates with a demonstrated track record of productivity through a body of publications, including in high-impact journals, will be considered. 
 
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sbpdiscovery.org.
Please visit [www.chandalab.org] for additional information.
La Jolla, CA
Postdoctoral Training Opportunity
Host-Pathogen Interactions and Neuroinflammation
Principal Investigator
Email Contact
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Marcus Kaul in projects investigating i) cellular and molecular mechanisms of host-pathogen interaction that lead to neuroinflammation and degeneration and ii) innate neuroprotective factors. A major focus is the neurotoxicity and brain injury associated with HIV-1 infection. The positions will be integral parts of studies dissecting molecular mechanisms of inflammatory and innate immune signaling pathways in macrophages and neural cell types using in vitro and in vivo models. The projects will combine molecular, cellular, biochemical as well as bioinformatics-based approaches, including NextGen Sequencing, RNAi, ASO, knockout and transgenic mouse models, etc. The positions are supported by NIH funding. 
Requirements
Highly motivated candidates who recently obtained a Ph.D. and/or M.D. degree, with a strong background either in neurobiology or inflammation, innate immunology, molecular biology and virology and biochemistry are encouraged to apply. Experience with transgenic and knockout or humanized mouse models and cellular signaling is a plus. Candidates must have good communication skills, and should be able to work independently in a highly interactive and collaborative scientific environment. Successful candidates will have a solid publication record in peer-reviewed journals.
 
Interested individuals should send their curriculum vitae, a brief description of their scientific background and interests, and the names of three references to mkaul@sbpdiscovery.org
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position in Molecular Virology
Principal Investigator
Research Description
Multiple postdoctoral positions are immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of virus-host interactions and innate responses.  These positions will be focused on elucidating multiple molecular features of host-pathogen interactions and responses to influenza, HIV, Dengue, West Nile and gammaherpes viral infection using systems-based approaches.   
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in virology, cell biology, and biochemistry are encouraged to apply.  In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.  Successful candidates will have a strong publication record in peer-reviewed journals. 
 
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sbpdiscovery.org. Please visit [www.chandalab.org] for additional information.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center in the laboratory of Dr. Carl Ware in La Jolla, CA. The Ware laboratory’s research focuses on the TNF superfamily of cytokines and their signaling pathways in autoimmunity, host response to viral pathogens and cancer. Successful candidates will work on in vitro, ex vivo and in vivo models to better understand the role of these cytokine pathways in disease and designing therapeutics. Projects include collaborative translational studies with Pharma R&D teams.
Requirements
Highly motivated candidates with a Ph.D., 3-4 years postdoctoral experience and a strong background in molecular and cellular immunology are encouraged to apply. Previous experience with mouse models is essential; familiarity with models for autoimmune diseases such as IBD a plus.  Experience with virus models, cellular immunological assays, flow cytometry and standard cellular and molecular biology techniques is also desired. Candidates must have excellent communication skills, a strong publication record and should be able to work both independently and in a collaborative environment.
 
Interested applicants should submit a CV, contact information of three references and a brief description of research accomplishments, interests and career goals to psnorris@sbpdiscovery.org.

Human Genetics

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Research Description
A Postdoctoral position is immediately available at the Sanford Burnham Prebys Medical Discovery Institute (SBP) to study NGLY1 mutations that cause a recently discovered human neurological disease of protein N-de-glycosylation. The pathological mechanism is unknown.
 
Our team combines cell biology, biochemistry, and human genetics in solve Congenital Disorders of Glycosylation (CDG) including NGLY1. Fundamental discoveries are aimed at translational applications that can benefit patients.
 
The postdoc will drive the project to identify consequences of disrupted N-glycan cleavage from misfolded glycoproteins that are retro-translocated into the cytoplasm. Plans include a search for obligate substrates, alternate cleavage pathways, potential therapeutic molecules, and analysis of patient cells. Techniques include gene manipulation, glycan analysis, fluorescence methods, and proteomic analysis.
 
Close collaborations with other NGLY1 research laboratories, the NIH, and philanthropic organizations provide unique interactive opportunities for the candidate.
 
If interested in this challenging research opportunity in NGLY1, please read PMID: 24651605, PMID: 25900930, and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2

Requirements

  • Recent PhD or MD/PhD with strong motivation and background in biochemistry, genetics, cellular & molecular biology.
  • First-author publications in any 2 of the following: biochemistry, cell biology, glycobiology, gene manipulation, ERAD or cytoplasmic protein degradation.
  • Excellent verbal/written communication skills in fluent English.
  • Previous experience in a biochemistry, genetics, or cellular/molecular biology lab based in the United States.
  • Independent self-starter who thrives in a highly interactive, collaborative scientific environment.

How to Apply:
Send a single PDF document that includes all of the following:

  • Your current CV
  • 1 page letter outlining your background, specific interest in NGLY1, and how you would like to study it.
  • 3 recent reference contacts for this project.

Email the PDF document to Dr. Hudson Freeze at azimmon@sbpdiscovery.org.

Development, Aging, and Regeneration

La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Research Description
A Postdoctoral position is available for a candidate to study the genetics underlying heart function and disease, using primarily Drosophila as a model system. Possible projects include using molecular-genetics, imaging and physiological techniques to understand the roles of ion channels in heart function/disease,  genes contributing to cardiac aging and the role of metabolism in cardiac function/dysfunction.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Karen Ocorr at kocorr@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
Directing differentiation of stem cells, endogenous cardiac progenitors or cardiac fibroblasts to create new muscle is an aspiration of regenerative medicine. To that end, it is crucial to comprehensively identify and characterize gene regulatory networks controlling cardiac cell fate. To date, less than 30 genes have been tested for their ability to induce cardiac reprogramming, showing only modest effects when overexpressed in fibroblasts. This project is to use high-throughput functional screening strategies in order to identify new determinants of cardiac cell fate and evaluate their role both in vitro and in adult models of cardiac regeneration.
 
The Colas lab is located at Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) which stands at the forefront of basic biomedical and translational science. The institute provides world-class facilities, including one of the 4 nationwide screening centers, and a cooperative environment, which promotes productive collaborations.
 
Recent Publications:
1 AR. Colas et al. 2016. Submitted to Cell Stem Cell
2 T. Cunningham, A Colas et al. 2015. Plos One
3 M. Mercola, A Colas et al. 2013. Cardiovascular Drug Discovery Circ Res
4 A. Colas et al. 2012. Genes and Development
5 W. McKeithan*, A. Colas* et al. 2012. Curr Protoc Stem Cell Biol
Requirements
Applicants must have a Ph.D or M.D, be highly motivated, and have a track record of accomplishments (i.e one or more first-authored publications).  Experience in one or more of the following areas is required: developmental biology, stem cell biology, mouse models and high-throughput screening.
 
To apply, please send a CV, a brief statement of your previous research expertise, and the contact information of three referees to Alexandre Colas at acolas@sbpdiscovery.org
 
 
 

Bioinformatics and Structural Biology

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Cardiovascular Metabolism

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Integrative Metabolism

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Job Duties
A Postdoctoral Associate position is available to study non-coding RNAs (long noncoding RNA and microRNAs) regulation in prostate and skin cancer.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified in our laboratory and we will characterize these through in-vitro and in-vivo functional and analytical genomics studies. 
 
The prospective candidate will continue this study at the Lake Nona site of SBP located in Orlando, Florida.
Required Experience/Skills
The Ph.D. and/or M.D.  Candidate must have a strong background in at least one of the following areas: tumor biology, cell biology, molecular biology, and/or transcriptional/post-transcriptional gene regulation/bioinformatics. Interested and qualified candidates should submit their CV, cover letter and list of references to Ms. Debbie McFadden at dmcfadden@sbpdiscovery.org.
 
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Description
Postdoctoral Associate positions are available to study epigenetic patterns and regulation within adipose tissue depots utilizing genome-wide analyses; bioinformatics; and molecular and cellular mechanisms.

Required Experience
Candidates must have a Ph.D. and/or M.D. and must have a strong background in molecular skills associated with genome-wide protein binding (ChIP and ChIP-seq), including bioinformatics analysis (microarray, ChIP-seq, and/or RNA-seq).  In addition, applicants must have experience in the following technical areas: maintenance and manipulation of mouse genetic models, isolation of animal tissues, as well as molecular and cell biology skills.  Experience with liver or adipose tissue biology is preferred.  Interested applicants should submit a cover letter including research accomplishments and interests, CV, and names of at least 3 references to pphelan@sbpdiscovery.org

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate in X-Ray Crystallography of Transcription Factors
Principal Investigator
Job Description
A Post-Doctoral Associate position is available in Dr. Rastinejad’s laboratory at the Sanford Burnham Prebys Medical Discovery Institute, in Lake Nona, Florida.  This position provides an exceptional opportunity to enhance the candidate’s past training in X-ray crystallography, biochemistry, molecular biology and/or cell biology.  The research training will emphasize protein expression through a variety of innovative methods, biochemical characterization of pure proteins, their crystallization and structure determination through modern macromolecular X-ray crystallography/diffraction methods.  Selected candidate will additionally become exposed to high throughput drug-screening efforts in which the laboratory collaborates wit the Conrad-Prebys Center for Chemical Genomics within the same Institute.
 
The transcription factors to be studied are nuclear hormone receptors and mammalian bHLH-PAS proteins.  Recent studies within Dr. Rastinejad’s laboratory have led to breakthroughs in the structural visualization of multi-domain transcription factors in a variety of functionally revealing complexes that include bound DNA, small-molecule ligands and coregulators.  The new projects will involve intensive protein biochemistry, crystal growth and structure calculation and refinement based on X-ray diffraction data.  The high-throughput screens will also be integrated throughout the structural biology training program, with the goal of identifying potent small-molecules that act as activators and inhibitors of transcription factors.
Required Education & Experience
Requires a Ph.D. degree in Biology, Biochemistry or related field. Candidates who have strong research experience in X-ray crystallography, protein purification and biochemical binding studies, molecular biology, and/or cell-biology are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment.  Interested candidates should apply with full CV, statement of research interests and list of references via LakenonaRecruitment@SBPdiscovery.org
 
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability. We are committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law.  For additional information about your rights as an applicant, click HERE.
 
Sanford Burnham Prebys Medical Discovery Institute endeavors to make its careers page accessible to any and all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process, please contact James DiStefano, Director, Human Resources at accommodations@sbpdiscovery.org. This information is for accommodation requests only and cannot be used to inquire about the status of applications.
Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Job Description
A postdoctoral Associate position is available to study the role of non-coding RNAs (long noncoding RNA and microRNAs) in cancer (prostate cancer and melanoma) metabolism.  Several putative oncogenic and tumor suppressor non-coding RNAs have been identified (Mazar et al Mol. Cell. Biol 2016, Wei et al., JID 2016) in our laboratory and we will characterize these through in-vitro and in-vivo functional and analytical genomics studies and associate them to cancer metabolism.
Requirements
The Ph.D. and/or M.D. candidate must have a strong background in at least one of the following areas: tumor biology, cell biology, molecular biology, and/or transcriptional/post-transcriptional gene regulation/bioinformatics. Interested and qualified candidates should submit their CV, cover letter and list of references to Ms. Debbie McFadden at dmcfadden@sbpdiscovery.org.
 
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability. We are committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law.  For additional information about your rights as an applicant, click HERE.
 
Sanford Burnham Prebys endeavors to make its careers page accessible to any and all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process, please contact James DiStefano, Director, Human Resources at accomodations@sbpdiscovery.org. This information is for accommodation requests only and cannot be used to inquire about the status of applications.

Genomic Control of Metabolism

There are no postdoctoral training opportunities in this program at this time.

Conrad Prebys Center for Chemical Genomics

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Eduard Sergienko, Ph.D.
Research Description
A postdoctoral position is available in the laboratory of Dr. Eduard Sergienko in the Conrad Prebys Center for Chemical Genomics, which is the chemical biology and drug discovery powerhouse of Sanford Burnham Prebys.  This position offers unique exposure to a hybrid academic-biotech environment.
Our research focuses on the development and optimization of biochemical and cell-based assays, high-throughput screening of large-scale small-molecule compound collections, structure activity relationship (SAR) and mechanism of action studies (MOA) on identified compound hits in a broad array of projects. SAR and MOA studies involve cellular target engagement studies, characterization of changes in enzyme properties caused by compounds using enzyme kinetic and thermodynamic applications, studies of compound binding using biophysical and biochemical approaches.
Requirements
Please apply if you are a highly motivated, collaborative and independent candidate with an M.D. or Ph.D. with 0-2 years of postdoctoral experience. The qualified candidate must have proven experience in one or more of the following areas: biochemistry, protein chemistry and/or enzymology. Research experience working with cultured cells and with the use of molecular biology experimental procedures preferred.
 
Qualified motivated individuals with a desire to expand their biochemistry expertise into chemical biology and drug discovery should submit their CV, in addition to the names, e-mail addresses, and telephone numbers of three references to Dr. Eduard Sergienko, Director, Assay Development, esergien@sbpdiscovery.org.  Please cc: jcolomb@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute endeavors to make its career pages accessible to any and all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process, please contact us at accommodations@sbpdiscovery.org. This information is for accommodation requests only and should not be used to inquire about the status of applications.

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.

Sanford Burnham Prebys Medical Discovery Institute will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information.

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