Current Postdoctoral Training Opportunities

Current Postdoctoral Training Opportunities

Tumor Initiation and Maintenance

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Charles Spruck, Ph.D.
Research Description
A Postdoctoral position is available to work on various projects that will explore the molecular regulations of cell division control and define how alterations of these processes contribute to cancer development and progression. An emphasis of these projects will be the ubiquitin proteasome system (UPS) and the role of protein destruction in cancer.
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the fields of DNA damage response and ubiquitin-dependent proteolysis are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Charles Spruck at cspruck@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Jing Crystal Zhao, Ph.D.
Postdoctoral Associates
We seek a highly motivated postdoctoral fellow to study the roles of RNA modification in stem cell biology and cancer development. mRNA and noncoding RNA modification, particularly methylation at the N6 position of adenosine (N6-methyladenosine), has emerged as an important research area in epigenetics and RNA biology. My lab identified a protein complex that governs N6-methyladenosine formation. We found such modification shortens the half-life of mRNAs, including developmental regulators, in mouse embryonic stem cells. Currently, we are digging deeper into the molecular mechanisms through which m6A regulates RNA activity, using a combination of biochemistry, cell biology, and high throughout sequencing technologies. Please refer to our recent publication for further information (Nature Cell Biology 16 (2): 191-8, Feb. 2014).  This position is expected to start in May 2015. Please also find the job posting online from naturejobs.
Requirements
Ph.D. and/or M.D. candidate with a background in biochemistry, molecular biology, cell biology, and/or animal models are encouraged to apply. Interested applicants should submit a CV, 3 reference letters, and a cover letter to czhao@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Elena Pasquale, Ph.D.
Research Description
A postdoctoral position is available in a leading laboratory with a longstanding successful track record in studying the Eph family of receptor tyrosine kinases. Our current research focuses on elucidating the dual signaling mechanisms of Eph receptors in tumor promotion and tumor suppression, characterizing Eph receptor cancer mutations, and developing new Eph receptor-targeting agents for cancer imaging/treatment and against neurodegenerative diseases. Projects involve biochemistry and cell biology approaches, phage display, in vivo mouse cancer models, and interdisciplinary collaborations.
Requirements
We are looking for a highly motivated, independent and collaborative individual with a recent (within the last 3 years) PhD or MD/PhD and demonstrated productivity through peer-reviewed publications, including at least one first-author publication. A strong background in molecular and cell biology and prior experience in signal transduction research are preferred but not required. Interested applicants should submit a single PDF file that includes their CV, a brief description of research accomplishments, interests and career goals, and contact information of at least three references to: Dr. Elena Pasquale at elenap@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Duties and Responsibilities
Post-doctoral research in the epigenetic regulation of normal and leukemic stem cells:
A postdoctoral position is available with a flexible start date in the field of leukemia epigenetics in the Deshpande Lab at SBP in San Diego, California. The Deshpande lab is interested in cancer epigenetics with a core focus on acute myeloid leukemia using mouse models. There is also a strong interest in normal hematopoietic stem cell biology.The candidate is expected to study normal and leukemic stem cells using genomic, epigenomic and biochemical methods.
 
Requirements
Highly motivated candidates with a recent Ph.D. in Cell Biology, Molecular biology, Genetics or relevant fields are encouraged to apply. Experience and expertise in cell and molecular biology (multi-parameter flow cytometry, chromatin immunoprecipitation, cell culture) and/or mouse models of hematopoiesis is highly desired. Basic knowledge of computational data analysis is a big plus but not a must. We are seeking collaborative individuals who are detail oriented, with excellent communication and data organization skills.
La Jolla, CA
Postdoctoral Training Opportunity
A Postdoctoral position is available to work on various projects that will explore the molecular regulation of cell cycle control and cell fate in pancreatic cancer. Specifically, we will define how signaling through bHLH proteins alters processes which contribute to cancer development and progression. An emphasis of these projects will be on reprogramming pancreatic cancer to restore the acinar transcriptional program through E47.
Principal Investigator
Tumor Initiation and maintenance
 
Requirements
Candidates must have a Ph.D. and have a strong background in molecular biology techniques. Experience in the field of cancer/transcriptional regulation/ bioinformatics are preferred, but not required. Interested applicants should submit a copy of their CV and a list of at least three professional references to: Dr. Pamela Itkin-Ansari at pitkin@sbpdiscovery.org.

Cell Death and Survival Networks

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position

Research Description
One joint postdoctoral position in the laboratories of Dr. Jorge Moscat and Dr. Maria Diaz-Meco in La Jolla, California, is available to study the role of metabolic reprograming in the tumor stroma and its impact on cancer progression and metastasis.

Our goal is to identify potential new therapeutic targets for innovative cancer treatment. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).

For more information about the Moscat and Diaz-Meco labs and the work we are doing, please visit http://www.sanfordburnham.org/Talent/Pages/JorgeMoscat.aspx and http://www.sbpdiscovery.org/Talent/Pages/MariaDiaz-Meco.aspx

Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism will be a plus. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sbpdiscovery.org.

The position is available starting immediately.

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Cosimo Commisso, Ph.D.
The Cell Death and Survival Networks Program of SBP located in La Jolla, CA, is recruiting a Postdoctoral Fellow to study cancer cell biology and tumor metabolism. The Commisso Lab (www.commissolab.com) is focused on biological discoveries that have the potential to lead to novel therapeutic strategies for cancer. Of particular interest to our laboratory are Ras-driven cancers, such as pancreatic cancer, which are extremely aggressive and are in urgent need of new and innovative therapies. The biological process that we study in the lab is called macropinocytosis, a fluid-phase form of bulk endocytic uptake, which we have linked to cancer cell metabolism in Ras-mutated tumors. We are seeking a highly motivated individual to join our research team. The successful candidate will be an active participant in a vibrant, collaborative atmosphere. The candidate will design and implement experiments using a variety of techniques such as cell culture, cell biology, molecular biology, and animal tumor models to help understand cancer cell metabolic dependencies at the molecular level. The main goal is to identify and develop novel therapeutic targets and to discover therapeutic agents to treat Ras-driven cancers.
Experimental bench science is an essential requirement, as well as the ability to present and discuss data. A research background in cancer biology or cell biology is required, as well as prior experience with mouse models of cancer, signal transduction, and/or microscopy. Candidates must have a Ph.D. degree and demonstrate the ability to successfully spearhead a research project as evidenced by first-author publications (published or in the process of submission). Interested applicants should submit a cover letter outlining their future research interests and a CV. The last page of the CV should include the contact information (e-mail address and phone number) for three references. The PDF files should be emailed to Dr. Cosimo Commisso at ccommisso@sbpdiscovery.org. Positions are available starting immediately. SBP offers generous benefits as an important part of our total rewards package designed to support the physical, emotional and financial health and well-being of our diverse workforce. Competitive salary will be offered and determined by the successful candidate's skills and qualifications.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
One fully funded postdoctoral position in the laboratory of Dr. Jorge Moscat in La Jolla, California, is available to study the role of autophagy adaptors and substrates in the metabolic control of the tumor microenvironment in hepatocellular carcinomas.
Our goal is to unravel the crosstalks between myofibroblasts, immune cells, and the liver parenchyma, to identify potential new targets for innovative cancer therapies. Publications describing ongoing studies have appeared in for example: Mol. Cell (2011, 2013), Cell Metab. (2006, 2011, 2014), Cancer Cell (2008, 2014), Cell (2009, 2011, 2013), and Cell Reports (2015).
 
For more information about the Moscat lab and the work we are doing, please visit http://www.sanfordburnham.org/Talent/Pages/JorgeMoscat.aspx
Requirements
We are looking for highly motivated and enthusiastic individuals who are interested in this very competitive topic, and with expertise in signal transduction and molecular and cellular techniques, as well as prior experience working with mouse models. Candidates must have a Ph.D. or M.D. degree and a publication record demonstrating expertise in cancer cell biology. Experience in cellular metabolism will be a plus. Interested applicants should submit a single PDF file containing CV, a brief description of research accomplishments, interests, and career goals, and contact information (e-mail address and phone number) of three references to Dr. Jorge Moscat at jmoscat@sbpdiscovery.org
 
The position is available starting immediately.

Tumor Microenvironment and Metastasis

La Jolla, CA
Postdoctoral Training Opportunity
Angiogenesis/Tumor Biology
Principal Investigator
William Stallcup, Ph.D.
Research Description
A postdoctoral position is available to study the function of the NG2 proteoglycan in both normal and tumor vascularization, building on the existing knowledge concerning NG2 participation in pericyte/endothelial cell interaction. A primary focus will be the investigation of NG2 function in mammary tumorigenesis, using both cell culture and animal models.
Requirements
Experience with relevant models, especially the use of histology and immunocytological imaging to study vivo mammary development and tumor progression, will be especially valuable. Expertise in areas such as cell biology, molecular biology, and biochemistry is also desirable. Candidates must have either a Ph.D. or M.D. and a publication record in one or more of the relevant areas. Interested applicants should submit a copy of their CV, and contact information (email address and phone number) of three references to: Dr. Bill Stallcup at stallcup@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
VEGF Biology in Pathophysiological Conditions
Principal Investigator
Sunyoung Lee, Ph.D.
Email Contact
slee@sbpdiscovery.org
Research Description
A Postdoctoral position in vascular biology is available in Tumor Microenvironment and Metastasis program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA. SBP has leading multi-disciplinary collaborative research groups, which is combining traditional developmental biology and molecular cell biology approaches with cutting-edge tools from chemistry, proteomics and engineering to develop entirely new approaches to cancer therapy. The current focuses in the lab include: to investigate the mechanism by which tumor microenvironment affects tumor angiogenesis and tumor progression, to study how vascular homeostasis is maintained and to study the interaction between vascular development and organogenesis.
Requirements
A recent Ph.D. or M.D/Ph.D. in molecular and cellular biology, cancer and developmental biology or biochemistry is required. Previous experience in animal work is highly desired. Good communication skills, organization skills, responsibility and an interactive team oriented attitude are also important factors. Interested applicants should submit a copy of their CV, a brief statement of research skills, and contact information (email address and phone number) of three references to: Dr. Sunyoung Lee at slee@sbpdiscovery.org.

Degenerative Diseases

La Jolla, CA
Postdoctoral Training Opportunity
Cell and Molecular Biology of Alzheimer's Disease
Principal Investigator
Huaxi Xu, Ph.D.
Email Contact
xuh@sbpdiscovery.org
Research Description
A Postdoctoral position is available to study molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease. Our research projects involve proteolytic processing and trafficking of beta-amyloid precursor protein, regulation of beta-amyloid generation and tau phosphorylation, and identification of novel genes and genetic pathways affecting beta-amyloid metabolism.
Requirements
Candidates must have a Ph.D. Outstanding candidates with expertise in cell and molecular biology are sought. Applicants with recent doctoral degrees should send their curriculum vitae contact information (email address and phone number) of three references to: Dr. Huaxi Xu at xuh@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Research Description
The laboratory of Dr. Randal Kaufman at SBP in La Jolla, California has an opening for a Postdoctoral Associate. The lab’s research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum. Various projects are available including studies directed to elucidate the molecular logic for the UPR adaptive response in the hopes of providing fundamental insight into numerous pathological conditions such as viral infection, cancer, inflammation, metabolic disease and atherosclerosis, and protein folding diseases such as Parkinsons disease and Alzheimers disease.
Requirements
Candidates for this position must have a PhD or MD. A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with genetically engineered mice is a plus. Technical skills will include molecular and cellular biology, protein biochemistry, and murine genetics.
 
Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Randal Kaufman, Ph.D.

Research Description
The laboratory of Dr. Randal J. Kaufman at SBP in La Jolla, California has an opening for a Postdoctoral Associate to work on the progression of fatty liver disease to non-alcoholic steatohepatitis and hepatocellular carcinoma.  Due to the obesity epidemic, this is expected to be a major focus for future research for years to come.
 
The lab’s research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum. Of most significance are recent discoveries regarding how protein misfolding impacts liver failure and development of non-alcoholic steatohepatitis and eventually hepatocellular carcinoma.  The lab has unique mouse models to answer questions that are not possible anywhere else in the world. Technologies will include liver physiology/pathology, especially lipid metabolism and inflammation. The lab uses the most sophisticated technologies including mRNA-Seq, high throughput small molecule/siRNA screening, mass spectrometry, electron microscopy and the most advanced methods of manipulating the murine genome.  The position requires working with mice, isolating liver for RNA, protein and lipid analysis and isolation/characterization of primary hepatocytes. The preferred candidate should have strong background in molecular and cellular biology, biochemistry and physiology.

Requirements
Candidates for this position must have a Ph.D. or M.D.
 
A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with mice is a plus. This is a truly unique position to work on a high profile project that will have impact on human medical care.
 
Interested applicants should submit a copy of their CV, contact information (email address and phone number) of three references, and a brief statement of research skills and interest to: Dr. Randal Kaufman c/o Taryn Goode: tgoode@sbpdiscovery.org.
 
Relevant Publications:
 
Nakagawa, et al. (2014) ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell26(3): 331-343.
 
Han et al. (2013) Endoplasmic reticulum (ER) stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biol. 15(5): 481-90. PMC3692270.
 
Wang et al. (2012) IRE1α-XBP1s induces PDI expression to increase MTP activity forhepatic VLDL assembly and lipid homeostasis. Cell Metabolism16(4): 473-86. PMC3569089
 
 
 

Immunity and Pathogenesis

La Jolla, CA
Postdoctoral Training Opportunity
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of innate immunology/pattern recognition receptor responses and virus-host interactions. This position will be focused on defining molecular mechanisms of certain innate immune signaling pathways in the context of pathogen infection using systems-based approaches. Studies will integrate both large-scale technologies (RNAi, AP-MS, NextGen Sequencing, etc.) and more traditional cell & molecular biology and biochemistry-based approaches. Positions are supported by NIH funding.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in immunology, virology, cell biology, and biochemistry are encouraged to apply. In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment. Successful candidates will have a strong publication record in peer-reviewed journals.

Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to: Crystal Herndon at cherndon@sbpdiscovery.org. Please visit www.chandalab.org for additional information.
La Jolla, CA
Postdoctoral Training Opportunities
Molecular Virology
Principal Investigator
Sumit Chanda, Ph.D.
Program
Immunity and Pathogenesis Program
Research Description
Multiple postdoctoral positions are immediately available in SBP Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda.  Positions will focus on generating a systems-level understanding of immune responses pathways including TLRs, cGAS, CD40 and Fc-mediated signaling.  Prospective candidates will play an important role in elucidating novel factors involved in the interplay between host innate immune factors and their implication in inflammatory and autoimmune disease.  Aspects of certain projects will involve collaborations with Pharma R&D teams.
Requirements
Highly motivated candidates who recently obtained a Ph.D., with a strong background in innate immune signaling are encouraged to apply.   The ideal candidate will have a deep understanding of the innate immune system including TLR, NLR, and RLR signaling as well as pathways induced in  myeloid & B cells.  In addition, experience in virology, cell biology, and biochemistry and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have good communication skills, and should be able to work independently and in a collaborative scientific environment.  Successful candidates will have a strong publication record in peer-reviewed journals. 
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sbpdiscovery.org. Please visit [www.chandalab.org] for additional information.
La Jolla, CA
Research Description
A postdoctoral position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program grant focused on generating a systems-level understanding of virus-host interactions and innate responses.  This position will be focused on elucidating multiple molecular features of host-pathogen interactions and responses to Dengue, West Nile and gammaherpes viral infection using systems-based approaches.   

Principal Investigator
Sumit Chanda, Ph.D.

Requirements
Highly motivated candidates who obtained a Ph.D. with a strong background in virology, cell biology, and biochemistry are encouraged to apply.  In addition, experience in innate immune signaling and an understanding and ability to apply statistical techniques to the analysis of large data sets are a plus. Candidates must have excellent communication skills, and should be able to work independently and in a collaborative scientific environment.  Successful candidates will have a strong publication record in peer-reviewed journals.  Prospective candidates with extensive experience in virology and innate immunity are strongly encouraged to apply. 
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to:  Crystal Herndon at cherndon@sbpdiscovery.org. Please visit [www.chandalab.org] for additional information.

Human Genetics

La Jolla, CA

Postdoctoral Training Opportunity

Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunities
Principal Investigator
Hudson Freeze, Ph.D.

Research Description
A postdoctoral position is immediately available at the Sanford Burnham Prebys Medical Discovery Institute to study NGLY1 mutations that cause a recently discovered human neurological disease of protein N-de-glycosylation. The pathological mechanism is unknown.
 
Our team combines cell biology, biochemistry, and human genetics in solve Congenital Disorders of Glycosylation (CDG) including NGLY1. Fundamental discoveries are aimed at translational applications that can benefit the patients.
 
The postdoc will drive the project to identify consequences of disrupted N-glycan cleavage from misfolded glycoproteins that are retro-translocated into the cytoplasm. Plans include a search for obligate substrates, alternate cleavage pathways, potential therapeutic molecules, and analysis of patient cells. Techniques include gene manipulation, glycan analysis, fluorescence methods, and proteomic analysis.

Close collaborations with other NGLY1 research laboratories, the NIH, and philanthropic organizations provide unique interactive opportunities for the candidate.
 
If interested in this challenging research opportunity in NGLY1, please read PMID: 24651605, PMID: 25900930, and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2

Requirements

  • Recent PhD or MD/PhD with strong motivation and background in  biochemistry, genetics, cellular & molecular biology
  • Publications in any 3 of the following: biochemistry, cell biology, glycobiology, ERAD or cytoplasmic protein degradation.
  • Excellent verbal/written communication skills in fluent English.
  • Independent self-starter, who thrives in a highly interactive, collaborative scientific environment.

How to Apply:
Send a single PDF document that includes all of the following:

  • Your current CV
  • 1 page letter outlining your background, specific interest in NGLY1, and how you would like to study it.
  • 3 recent reference contacts for this project.

Email the PDF document to Dr. Hudson Freeze at azimmon@sbpdiscovery.org

Development, Aging, and Regeneration

La Jolla, CA
Postdoctoral Training Opportunity
Analysis of Cardiac Genes
Principal Investigator
Rolf Bodmer, Ph.D.
Email Contact
rolf@sbpdiscovery.org
Research Description
A Postdoctoral position is available for a candidate to study the genetic control of the heart, using primarily Drosophila as a model system. Possible projects using molecular-genetic, imaging and physiological techniques range from analysis of early cardiogenic genes to genes controlling heart function and cardiac aging to genes involved in left-right asymmetry.
Requirements
Candidates must have a Ph.D. Interested applicants should submit a copy of their CV and contact information (email address and phone number) of three references to: Dr. Rolf Bodmer at rolf@sbpdiscovery.org.
La Jolla, CA
Postdoctoral Training Opportunity
Development and Disease
Principal Investigator
Research Description
We seek individuals who are rigorous, productive, full of curiosity, have a persistent will to solve problems, always seeking new ideas and concepts, have effective communication skills, and who works well with others. The PI is devoted rigorous science and mentoring, emphasizing research philosophy and career advancement. Available projects range from basic developmental mechanisms and progenitor cell fate regulation, to modeling diseases, to genetic/chemical screens, and to in vivo genetic/chemical cell fate reprograming, and/or create your own projects. Please see our lab website.
Requirements
Postdoctoral candidates should have a Ph.D. or an M.D. with a solid background in molecular biology, development and genetics, or cell biology/biochemistry and at least one senior author publication. -omics experience is a plus.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Alexey Terskikh, Ph.D.
Research Description
A post-doctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, SBP, La Jolla, California. The position focuses on understanding the role of SoxB1 factors in in self-renewal and differentiation of normal and neoplastic neural stem cell. A candidate will undertake a comprehensive analysis of SoxB1 interactome and function combining the expression analysis, proteome, and chromatin binding assays. The long-term goal of this project is to identify novel genes and pathways as well as develop small molecules either enhancing adult hippocampal neurogenesis or inducing differentiation of cancer “stem cells."
Requirements
The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.

Interested candidates should contact the PI, Dr. Alexey Terskikh at Terskikh@sbpdiscovery.org.

Please send a detailed resume, summary of previous work, electronic reprints of recent publications, and names and contact information for three references.
La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
 
Research Description
A post-doctoral fellow position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, SBP, La Jolla, California. The position focuses on the novel approaches to study epigenetics at a single cell level. A candidate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL), a novel platform developed in our laboratory. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells. A candidate will investigate the epigenetic heterogeneity at the single cell level (3D) during normal neurogenesis and in brain tumors. The long-term goal of this project is to identify unique epigenetic signatures that could classify normal cells in the body as well as neoplastic tumor cells and help their prospective isolation.
The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.

Interested candidates should contact Dr. Alexey Terskikh (Terskikh@sbpdiscovery.org).

Please send a detailed resume, summary of previous work, electronic reprints of recent publications, and names and contact information for three references.

Bioinformatics and Structural Biology

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Position
Principal Investigator
Niels Volkmann, Ph.D.
Research Description
A postdoctoral position is immediately available in the laboratory of Dr. Niels Volkmann, Sanford Burnham Prebys Medical Discovery Institute (SBP), located on the Torrey Mesa in La Jolla, walking distance from Salk, Scripps, and UCSD (La Jolla, CA, USA).

Our research focuses on the development and application of approaches for structure determination of small and structurally heterogeneous macromolecules by cryo-EM (many of them helical) as well as for reconstruction and interpretation of cellular tomograms obtained by cryo-electron tomography. All work will be conducted in close collaboration with Dr. Dorit Hanein’s experimental cryo-EM group at SBP.
Requirements
The successful candidate should be highly motivated and have a PhD in structural biology, image processing or a related subject, good communication skills and a strong analytical mind. Preference will be given to experts in algorithm design and scientific computer programming with a proven interest in structural biology and to candidates who have excellent skills in experimental cryo-EM and application of structure determination approaches such as single-particle, helical, or tomographic reconstruction methods.

Candidates should send a CV, statement of research interest and focus, and provide the contact information for at least three professional references to Dr. Niels Volkmann, niels@sbpdiscovery.org.

Cardiovascular Pathobiology

Lake Nona, FL
Postdoctoral Associate
Dr. Peter Crawford and Dr. Xianlin Han
Cardiovascular Pathobiology
We are seeking a talented, dynamic, and self-motivated post doctoral associate with experience in analytical chemistry to perform lipidomics and metabolomics analyses to train in the labs of Dr. Peter Crawford and Dr. Xianlin Han. The candidate will utilize specialized analytical techniques such as multi-dimensional mass spectrometry-based shotgun lipidomics, liquid chromatography-mass spectrometry (LC-MS), and informatic approaches to chemical feature identification, metabolic pathways analysis, and fluxomics to quantitate thousands of lipid species and metabolites in a high throughput manner to reveal the underlying mechanism(s) responsible for the changes of lipidome/metabolome under the selected pathological condition(s). He/she will become highly proficient in these techniques, analyses, and data interpretation, and be charged with the experimental design, sample collection and preparations, metabolite analyses by a variety of mass spectrometric techniques, data analysis and interpretation, manuscript preparation, and data presentation at national and international conferences. The postdoc will also be responsible for assisting with the maintenance of numerous mass spectrometers present in the laboratories as well as training new incoming scientists in these experimental techniques.
 
SPECIFIC RESEARCH FOCUS:
 
The primary research focus will be a translational and collaborative project between the Han and Crawford laboratories. The project will employ lipidomics/metabolomics approaches to study the altered metabolism by using human tissue samples to study heart failure, fatty liver diseases, or pancreatic disorder of diabetes/obesity individuals and to identify the underlying molecular mechanism(s) responsible for the alterations under the selected pathological condition.
Requires a doctoral degree in Biochemistry or related field. Candidates who have research experience in biochemistry/analytical chemistry are strongly preferred. Ideal candidate would be motivated, possess excellent written and oral communication skills and possess a strong desire and ability to work as a team in a collaborative environment. Interested candidates should apply with full CV, statement of research interests and list of references via LakenonaRecruitment@SBPdiscovery.org

Metabolic Disease

Lake Nona, FL
Postdoctoral Training Opportunity
Postdoctoral Associate
Principal Investigator
Timothy Osborne, Ph.D.
Program Name
Metabolic Disease
Research Description
A Postdoctoral Associate position is available to study immune system regulation of mammalian lipid metabolism through cellular, molecular and genetic mechanisms.

Sanford Burnham Prebys Medical Discovery Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity. SBP has recently finished building 175,000 sq.ft. state-of-the-art laboratory facilities for over 300 faculty and staff. The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and metabolic research, with a strong interdisciplinary collaborative approach to scientific study.
Requirements
Candidates must have a Ph.D. and or M.D. and must have a strong background in technical skills in the following areas: mouse metabolism and inflammation including immunological methods such as immune cell isolation, phagocytosis, apoptosis, cytokine analysis, flow cytometry and immunohistochemistry as well as strong molecular and cell biology skills. Interested applicants should submit a cover letter including research accomplishments and interests, CV and names of at least three (3) references to pphelan@sbpdiscovery.org

Genomic Control of Metabolism

There are no postdoctoral training opportunities in this program at this time.

Conrad Prebys Center for Chemical Genomics

La Jolla, CA
Postdoctoral Training Opportunity
Postdoctoral Positions
Principal Investigator
Anne Bang
Research Description
The successful candidate will be primarily responsible for conducting research related to developing patient specific, cell based, “disease in a dish” models for neurodegenerative disease to screen for drugs, validate new targets and chemical molecules, and probe underlying cellular and molecular processes. The project will focus on the development of models representing neurodegenerative disease phenotypes, using patient specific induced pluripotent stem cells (iPSC), and will utilize high throughput drug screening technologies. The position is at SBP in Dr. Anne Bang’s lab in the Conrad Prebys Center for Chemical Genomics, a state-of-the-art drug screening facility. The position will be initially available for one year, with renewal based on performance.
Requirements
This position requires an M.D., or Ph.D., with preference for new graduates or for postdocs with 2 or fewer years of experience. The qualified applicant must have proven experience in one or more of the following areas: cell biology, developmental biology, stem cell biology, neurobiology. Research experience working on Alzheimer’s or other neurodegenerative diseases would be considered an advantage.
 
Interested individuals should submit CV and names, e-mail addresses, and telephone numbers of three references.
 
Anne G. Bang, PhD
Director, Cell Biology
Conrad Prebys Center for Chemical Genomics
Sanford Burnham Prebys Medical Discovery Institute
10901 North Torrey Pines Road
La Jolla, CA 92037
abang@sbpdiscovery.org
Office: 858-795-5118
Cell: 858-401-2788

 
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