CMOD Center

Center for Metabolic Origins of Disease

"Our scientists seek to explore the metabolic basis of disease and to rapidly translate discovery to clinical care by leveraging bridges we have built with clinical partners."

Daniel Kelly, M.D.
Scientific Director, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
Tavistock Distinguished Professor

About the Center

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Thematic Foci of the Center

microscope eyepiece
Fundamental discovery

...to elucidate the pathophysiology of common metabolic diseases and corresponding cardiovascular complications.

scientist handles samples
Drug discovery technologies

...to identify bioactive compounds and optimize lead candidates with the goal of identifying drug candidates.

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Translational studies

...to move discovery toward new paradigms in patient care.

Programs

Cardiovascular Metabolism
Cardiovascular Metabolism Program
Investigating the body’s metabolism system is leading to novel targets and therapeutics aimed at cardiovascular disease.
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illustration of interior of cell nucleus
Genomic Control of Metabolism Program
Genetic blueprints teach us how genetic, genomic and epigenetic mechanisms control physiology and metabolism in health and disease.
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Integrative Metabolism Program
Integrative Metabolism Program
Fundamental and translational research in metabolism can help solve obesity-related diabetes and its complications.
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