2013 Sanford-Burnham Annual Symposium

35th Annual Sanford-Burnham Symposium

Epigenetics: Developments and Disease

October 24, 2013
8:30 a.m. – 4:00 p.m. PT
Estancia La Jolla Hotel
La Jolla, California

This year’s event is specifically focused on Epigenetics, a fundamental element in the regulatory network of gene expression. We will be hearing from experts in the key areas of epigenetics, including DNA methylation, noncoding RNA, and chromatin modification. We’ll discuss how epigenetics is involved in human development and how activators or inhibitors of these processes can be used to treat human diseases such as immune deficiencies and cancer.

Symposium Flyer



Continental Breakfast: 8:00 a.m. - 8:30 a.m.

Welcome & Introduction - 8:30 a.m.

John C. Reed
Kristiina Vuori, M.D., Ph.D.
President and interim CEO, Sanford-Burnham Medical Research Institute

Session 1: 8:40 a.m. - 10:20 a.m.

Moderator: Tariq Rana

Roles of RNA in Epigenetic Processes

8:40 a.m. - 9:10 a.m.

Thomas Cech

Promiscuous RNA Binding by PRC2: a Model for Maintenance of Repressed Chromatin

Thomas Cech, Ph.D.
Nobel Laureate and Distinguished Professor, University of Colorado, Boulder

9:15 a.m. - 9:45 a.m.

Shiv Grewal

Epigenetic genome control by heterochromatin and RNAi machinery

Shiv Grewal, Ph.D.
Laboratory Chief, National Cancer Institute

9:50 a.m. - 10:20 a.m.

Ramin Shiekhattar

Biogenesis and mechanism of action of enhancer RNAs

Ramin Shiekhattar, Ph.D.
Professor, The Wistar Institute

Coffee Break: 10:25 a.m. - 10:45 a.m.

Session 2: 10:50 a.m. - 12:00 p.m.

Moderator: Crystal Zhao

Nucleic Acid modification and regulation of gene expression

10:50 a.m. - 11:20 a.m.

Anjana Rao

TET proteins and methylcytosine oxidation

Anjana Rao, Ph.D.
Professor, La Jolla Institute for Allergy and Immunology

11:25 a.m. - 11:55 a.m.

Yi Zhang

Mechanism and function of Tet-regulated dynamic DNA methylation

Yi Zhang, Ph.D.
Investigator, Boston's Children's Hospital

12:00 p.m. - 12:30 p.m.

Crystal Zhao

The role of RNA modification in regulating mRNA stability

Crystal Zhao, Ph.D.
Assistant Professor, Sanford-Burnham Medical Research Institute

Lunch: 12:30 p.m. - 1:45 p.m.

Session 3: 1:50 p.m. - 4:05 p.m.

Moderator: Lorenzo Puri

Epigenetics in Development, Cancer and Immunity

1:50 p.m. - 2:20 p.m.

Ali Shilatifard

Chromosomal Translocations and Transcriptional Control in Epigenetics and Cancer

Ali Shilatifard, Ph.D.
Investigator, Stowers Institute for Medical Research

2:25 p.m. - 2:55 p.m.

Bing Ren

Epigenetic Control of Pluripotency and Lineage-specification

Bing Ren, Ph.D.
Professor, University of California, San Diego

Coffee Break: 3:00 p.m. - 3:20 p.m.

3:25 p.m. - 3:55 p.m.

Bing Ren

The Epigenetic Basis of Common Human Disease

Andrew Feinberg, M.D., M.P.H.
Professor, John Hopkins University School of Medicine

4:00 p.m. - 4:30 p.m.

Bing Ren

A genomic framework for macrophage function

Gioacchino Natoli, M.D., Ph.D.
FIRC Institute of Molecular Oncology Foundation and European Institute of Oncology

Closing Remarks - 4:30 p.m.

Kristiina Vuori
Kristiina Vuori, M.D., Ph.D.
President and interim CEO, Sanford-Burnham Medical Research Institute

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