Cancer

Cancer, while the second leading cause of death in the United States, is not just one disease. It's a condition in which cells break the most fundamental rules of behavior. For any number of reasons, cancer cells fail to repair damaged DNA, they reproduce without restraint, colonize other tissues in the body and ignore signals telling them to self-destruct. The causes and consequences of cancer differ from type to type, and from patient to patient. On a molecular level, rarely are any two cancers exactly the same.

SBP research on cancer

The cells shown here are dividing normally. In cancer, tumors form when cells continue to divide unchecked.

Scientists in each of the SBP Cancer Center’s three programs – Tumor Initiation and Maintenance, Cell Death and Survival Networks, and Tumor Microenvironment and Metastasis – are interested in the most fundamental questions about cancer: How do tumors arise from normal cells? What happens to cellular communication as cancer develops? How do cancer cells interact with their neighboring tissues? How do cancer cells avoid cell death? Researchers hope to apply the answers to these questions toward the development of targeted technologies that deliver anti-cancer drugs specifically to the tumor – thereby avoiding side-effects – and therapeutics to trick cancer cells into committing suicide by restoring a natural cell death mechanism.

Below are just a few examples of SBP multi-pronged approach to understanding and combating cancer at each step in the progression of the disease:

For more information

SBP does not provide clinical care for cancer or for other diseases. However, there are many organizations that do, nationwide and in California and Florida. If you are looking for a medical doctor or clinical trial, please visit this list.

National Cancer Institute (NCI), part of the National Institutes of Health (NIH)
http://www.cancer.gov/

American Cancer Society
http://www.cancer.org/

American Association for Cancer Research
http://www.aacr.org/

Susan G. Komen for the Cure
http://ww5.komen.org/

Stand Up To Cancer
http://su2c.standup2cancer.org/

Research - Cancer - Your Health: SBMRI's Work
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Genes and Cancer: Tumor Development
Communications Breakdown: Signal Transduction
Rebuilding Cancer’s Neighborhood: Tumor Microenvironment
Unlocking the Secrets of Cell Death: Apoptosis and Cell Death Research
Breast Cancer
Cancer Support Groups