Brooke Emerling, Ph.D.

Brooke Emerling's Research Focus

Related Diseases > Breast Cancer, Cancer
Phenomena or Processes > Cancer Biology, Cancer Metabolism, Cell Signaling, Metabolic Processes, Signal Transduction

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) in cancer metabolism. We have shown that the loss of function of the PI5P4K enzymes results in synthetic lethality with p53 loss. Our current work focuses on determining the role of the PI5P4K enzymes in p53 deficient cancers, especially the triple negative breast cancer subgroup where targeted therapies have not been effective.

Brooke Emerling's Bio

Dr. Emerling received her Ph.D. in Molecular and Cellular Biology from Northwestern University and trained as a Postdoctoral Fellow at Harvard Medical School.

Funding Awards and Collaborative Grants

Breast Cancer Research Foundation - AACR Career Development Award for Translational Breast Cancer Research
Mary Kay Foundation Innovative Translational Grant Award
Department of Defense Breast Research Program Breakthrough Award

Honors and Recognition

AACR – Aflac Travel Fellowship Award (2013) 
Mastercard Ajay Banga Scientist Award (2013-2016) 
NextGen Star – AACR Early-Career Speaker Award (2014)

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Publications

Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC
Proc Natl Acad Sci U S A 2016 Jul 5;113(27):7596-601
Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT
Mol Cell 2016 Jan 21;61(2):187-98
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Cell 2013 Nov 7;155(4):844-57
Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC
Proc Natl Acad Sci U S A 2016 Jul 5;113(27):7596-601
Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT
Mol Cell 2016 Jan 21;61(2):187-98
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Cell 2013 Nov 7;155(4):844-57