Francesca Marassi, Ph.D.

Francesca Marassi's Research Focus

Related Diseases > Cancer, Infectious Diseases, Computational Biology

Dr. Marassi's research focuses on understanding the structures and functions of proteins embedded in cellular membranes. Membrane proteins mediate all interactions of a cell or organism with the outside world and, as such, are responsible for the basic human experiences (taste, smell, touch, sight, thought, etc.) that constitute life. They are encoded by at least 30 percent of all genes and perform essential biological functions that include cellular transport, signaling, and programmed cell death. Dysfunctions of human membrane proteins are linked with devastating diseases and the membrane proteins encoded by viruses and bacteria play major roles in infection, virulence, and antibiotic resistance. It is, therefore, not surprising that membrane proteins are the principal targets of most drugs on the market today and that understanding their biological functions is a major goal of biomedical research. 

The three-dimensional structure of a protein is essential for understanding its mechanisms of action, for medicinal chemistry efforts, and for the development of therapies. Dr. Marassi’s primary research tool is NMR spectroscopy, a powerful technique that utilizes strong magnetic fields to extract structural information from biological molecules and characterize their interactions with their cellular partners. Her laboratory uses complementary approaches of solution NMR and solid-state NMR for proteins that are embedded in lipid bilayers to obtain direct information about three-dimensional structure and membrane orientation.

Francesca Marassi's Bio

Dr. Marassi earned her Ph.D. in Chemistry from the University of Toronto in 1993. She received postdoctoral training at the University of Pennsylvania, where she held fellowships from the Natural Sciences and Engineering Research Council of Canada (1993-1995) and from the Medical Research Council of Canada (1995-1998). In 1998, Dr. Marassi joined the Division of Structural Biology at the Wistar Institute in Philadelphia, as Assistant Professor and, in 1999, she was appointed Wistar Professor of Pharmacology at the University of Pennsylvania. In December 2000, Dr. Marassi joined SBP as Assistant Professor. She is currently Professor in the NCI-Designated Cancer Center.

CMSN Accessory

Publications

Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ
Nature 2012 Nov 29;491(7426):779-83
Yao Y, Barghava N, Kim J, Niederweis M, Marassi FM
J Mol Biol 2012 Feb 17;416(2):208-20
Tian Y, Schwieters CD, Opella SJ, Marassi FM
J Magn Reson 2012 Jan;214(1):42-50
Godoi PH, Wilkie-Grantham RP, Hishiki A, Sano R, Matsuzawa Y, Yanagi H, Munte CE, Chen Y, Yao Y, Marassi FM, Kalbitzer HR, Matsuzawa S, Reed JC
J Biol Chem 2016 Jul 1;291(27):14072-84
Yao Y, Nisan D, Fujimoto LM, Antignani A, Barnes A, Tjandra N, Youle RJ, Marassi FM
Protein Expr Purif 2016 Jun;122:56-63
Bartra SS, Ding Y, Fujimoto LM, Ring JG, Jain V, Ram S, Marassi FM, Plano GV
Microbiology 2015 Nov;161(11):2174-83