Garth Powis, D. Phil.

Garth Powis D. Phil., headshot

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Garth Powis' Research Focus

Related Diseases > Cancer

Solid tumors exist in a stressed environment for cell growth. In order to survive, cancer cells initiate specific adaptive and constitutive changes allowing them to adapt to the hostile hypoxic environment, escape cell death and increase formation of new blood vessels and metastasis. All of these responses lead to highly aggressive tumors that are resistant to therapy. In order to identify novel targets for therapeutic intervention that is applicable to a wide variety of tumor types, our lab studies the mechanisms that enable cancer cells to survive stress.

Garth Powis' Bio

Powis is a native of the U.K., where he trained at Oxford University. He worked at the Mayo Clinic, becoming deputy chair of Pharmacology; at University of Arizona Cancer Center as director of Basic Research; and most recently at MD Anderson Cancer Center, where he served as chair of Experimental Therapeutics and director of the Center for Targeted Therapy.

Powis is a molecular and translational pharmacologist with more than 350 publications and 15 patents. His research focuses on the mechanisms that enable cancer cells to survive stress. Powis’ work has resulted in three novel cancer drugs currently in clinical trials. The expertise he brings to SBP encompasses all stages of cancer drug discovery and development, from early target identification to clinical studies with cancer patients.

 

Education

1970 Merton College, Oxford, United Kingdom, D. Phil., Biochemistry and Pharmacology 

1967 Birmingham University, England, United Kingdom, B.Sc., Hons. (1st Class), Biochemistry and Pharmacology

 

CMSN Accessory

Publications

Kim YH, Liang H, Liu X, Lee JS, Cho JY, Cheong JH, Kim H, Li M, Downey TJ, Dyer MD, Sun Y, Sun J, Beasley EM, Chung HC, Noh SH, Weinstein JN, Liu CG, Powis G
Cancer Res 2012 May 15;72(10):2512-21
Sheveleva EV, Landowski TH, Samulitis BK, Bartholomeusz G, Powis G, Dorr RT
Mol Cancer Res 2012 Mar;10(3):392-400
Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, Tang X, Papadimitrakopoulou V, Minna JD, Lippman SM, Hong WK, Herbst RS, Wistuba II, Heymach JV, Powis G
J Natl Cancer Inst 2012 Feb 8;104(3):228-39
Chang HR, Nam S, Lee J, Kim JH, Jung HR, Park HS, Park S, Ahn YZ, Huh I, Balch C, Ku JL, Powis G, Park T, Jeong JH, Kim YH
Oncotarget 2016 Oct 28;
Lee MS, Helms TL, Feng N, Gay J, Chang QE, Tian F, Wu JY, Toniatti C, Heffernan TP, Powis G, Kwong LN, Kopetz S
Oncotarget 2016 Jun 28;7(26):39595-39608
Grandjean G, de Jong PR, James BP, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby KN, Powis G
Cancer Res 2016 Jul 15;76(14):4259-69