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Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Maria Diaz-Meco headshot
Meet a Scientist

Maria Diaz-Meco, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

We are trying to better categorize tumor aggressiveness in order to help clinicians make more informed decisions about how to trea...

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

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Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

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Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

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Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Maria Diaz-Meco headshot
Meet a Scientist

Maria Diaz-Meco, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

We are trying to better categorize tumor aggressiveness in order to help clinicians make more informed decisions about how to trea...

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP Pipeline graphic
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Drug discovery projects

News

AJHG logo
Paper of the Week
Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation
Padres Pedal
Beaker Blog January 26, 2018
Padres Pedal the Cause presents largest annual contribution to cancer research
Padres Pedal the Cause presented a check for $2,401,523.00 on Wednesday, January 24 to leaders from Sanford Burnham Prebys Medical Discovery Institute (SBP), Mo...
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Brain image
Press Release
January 24, 2018
Discovery may advance neural stem cell treatments for brain disorders
New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) is among the first to describe how an mRNA modification impacts the life of neural st...
Nature Neuroscience logo
Paper of the Week
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
Science logo
Paper of the Week
Recurrent infection progressively disables host protection against intestinal inflammation
most popular written on chalkboard
Beaker Blog January 9, 2018
Year in review: Top stories in 2017
In the last 12 months, SBP scientists published 338 scientific papers — that's almost a paper a day. We are proud of this impressive achievement, and equally pr...
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Astrocyte cells
Beaker Blog January 8, 2018
Brain map connects brain diseases to specific cell types
Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Park...
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jbc logo
Paper of the Week
A herpesvirus entry mediator mutein with selective agonist activity for the inhibitory receptor B and T lymphocyte attenuator
muscle stem cells
In the News
January 3, 2018
Muscle stem cells respond differently to aging, injury, researchers find
Muscular Dystrophy News
Food poisoning
In the News
December 27, 2017
Does food poisoning cause inflammatory bowel disease?
Forbes Online
Eurekalert logo
In the News
December 26, 2017
2017 top science news release breaks EurekAlert!'s all-time record
EurekAlert!
Journal of Clinical Investigation
Paper of the Week
SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth
1 of 3

1 out of 3 people are obese. Find out how our groundbreaking research can impact your future. 

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