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Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

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Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of heal...

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Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

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Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

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Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of heal...

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only p...

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar) cha...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP Pipeline graphic
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Drug discovery projects

News

Illustration of a hair follicle
Beaker Blog August 16, 2018
Hair-raising progress: Catching up with hair-growth researcher Alexey Terskikh
Three years ago, Alexey Terskikh, Ph.D. , associate professor in Sanford Burnham Prebys Medical Discovery Institute’s (SBP’s) Development, Aging and Regeneratio...
Read more
abstract image of two people with mosaic in background
Beaker Blog August 15, 2018
Surprising science: Not all our cells have the same DNA
We learned in biology class that every cell in the body has the same DNA. Whether a heart cell, skin cell or muscle cell—they all read from the same genetic blu...
Read more
Connective tissue cells (stroma) and cancer cells interact
Beaker Blog August 9, 2018
Cancer cells lure in nutrient-rich neighbors, then mug them
If your grocery store was out of food, would you still invite your friends to a dinner party? Unless you happen to have a flourishing garden, probably not. Our...
Read more
A cancer cell (green) surrounded by structure-supporting stroma cells (red). DNA shown in blue.
Beaker Blog August 9, 2018
SBP explains: fluorescence microscopy
The image above is not only stunning, it’s also helping scientists uncover the secrets to cancer and additional diseases. Petrus R. De Jong, M.D., Ph.D. The tec...
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Melanoma in Layers of the Human skin, Cancer
Beaker Blog August 6, 2018
Taking out a microRNA to thwart melanoma
Melanoma is a deadly disease with limited treatment options. However, even when those therapies are initially successful, the cancer often comes back. Researche...
Read more
Journal of Neuroscience logo
Paper of the Week
Arginine methyltransferase PRMT8 provides cellular stress tolerance inaging motoneurons
Laszlo Nagy M.D. Ph.D. Nerve Cell Journal of Neuroscience
Beaker Blog July 30, 2018
Protecting motor neurons
Enzyme PRMT8 can protect aging motor neurons from stress, which could have therapeutic implications.
Read more
nature cell biology logo
Paper of the Week
Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
Pier Lorenzo Puri M.D. Nature Cell Biology Sanford Burnham Prebys Medical Discovery Institute
Press Release
July 26, 2018
Dr. Jekyll, Mr. Hyde: Study reveals healing mesenchymal cells morph and destroy muscles in models of spinal cord injury, ALS and spinal muscular atrophy
SBP scientists have discovered a new disease-specific role of FAP cells in muscle wasting and scarring.
Adult Muscle Cell Pier Lorenzo Puri
In the News
July 26, 2018
Muscle discovery could open new treatment paths for ALS and other neuron disorders
FierceBiotech
UC San Diego Preuss School Interns Class Summer 2018
Beaker Blog July 23, 2018
Students conduct real-world research at SBP
High school students from The Preuss School UCSD spent part of their summer working alongside SBP scientists.
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Profile photos of Louie Coffman and Angelica Gamble-Wong
Press Release
July 17, 2018
SBP Leadership Appointments: Louie Coffman joins as CFO and Angelica Gamble-Wong as VP, Human Resources
Louie Coffman joins as Chief Financial Officer and Angelica Gamble-Wong as Vice President of Human Resources
7.5M

August is National Psoriasis Awareness Month. Around 7.5 million Americans suffer from psoriasis, a chronic autoimmune condition that SBP scientists are working on improving.

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