Jerold Chun with brain graphic

Alzheimer’s disease
breakthrough

Never-before-seen DNA recombination in the brain
reveals a potential near-term treatment.
 

Read the story     Watch the video

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

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Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of...

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

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Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

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Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the...

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Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of...

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
Hudson Freeze, Ph.D. headshot
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

SBP Pipeline - Current Projects

SBP Pipeline graphic
Learn more
Drug discovery projects

News

Scientist analyzing DNA gel- Sanford Burnham Prebys
Press Release
December 11, 2018
Loss of two genes drives a deadly form of colorectal cancer, reveals a potential treatment
Colorectal cancers arise from earlier growths, called polyps, found on the inner surface of the colon. Scientists are now learning that polyps use two distinct...
Hudson Freeze, Ph.D., Sanford Burnham Prebys
Beaker Blog December 11, 2018
Parents gain answers about their child’s mysterious condition, thanks to SBP scientists
For the parents of a six-year-old Hispanic boy and a seven-year-old Qatari girl, answers remained elusive. Both children had alarming symptoms, including...
Read more
immunity logo
Paper of the Week
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance
Epigenetics Symposium-Lorenzo Puri, Ani Deshpande, Peter Adams
Beaker Blog November 28, 2018
World-renowned scientists speak at SBP’s symposium on a booming research area: epigenetics
DNA contains more information than scientists previously thought. A booming field of research called epigenetics is uncovering DNA alterations that affect...
Read more
Gaurav Pathria, Garth Powis- Eric Dudle Scholarship
Beaker Blog November 28, 2018
Scholarship honoring late SBP scientist Eric Dudl awarded at Cancer Center Open House
Twelve years ago, Eric Dudl had begun his postdoctoral research at Sanford Burnham Prebys Biomedical Research Institute (SBP) when he received shocking news. He...
Read more
Team Sanford Burnham Prebys-Padres Pedal the Cause
Beaker Blog November 27, 2018
Team SBP raises more than $30,000—and counting—for cancer research at Padres Pedal the Cause
More than 60 scientists, staff and supporters of Sanford Burnham Prebys Medical Discovery Institute (SBP) ran, walked, biked and volunteered to raise critical...
Read more
Brain with and without Alzheimer's Disease
In the News
November 21, 2018
‘Landmark study’ shows brain cells revamp their DNA, perhaps sparking Alzheimer’s disease
Science Magazine
Beta amyloid protein-Alzheimer's disease
In the News
November 21, 2018
Morphing brain DNA hints at a whole new way to treat Alzheimer’s
New Scientist
San Diego Union-Tribune Logo
In the News
November 21, 2018
HIV drugs may help people with Alzheimer's and Down syndrome, says new hypothesis on Alzheimer's origins
The San Diego Union-Tribune
3D illustration of Interconnected neurons with electrical pulses
Press Release
November 21, 2018
Never-before-seen DNA recombination in the brain linked to Alzheimer’s disease
New technology reveals DNA in neurons is “mixed and matched,”producing thousands of previously unknown gene variations—and identifying a potential near-term treatment for Alzheimer’s disease
Nature logo
Paper of the Week
Somatic APP gene recombination in Alzheimer’s disease and normal neurons
Sanford Burnham Prebys 2018 Gala
In the News
November 16, 2018
Making Medical Miracles: SBP’s fundraising gala
The San Diego Union-Tribune
5.7m

5.7 million Americans are living with Alzheimer’s. By 2050, this number is projected to rise to nearly 14 million. SBP research hopes to change that.

Learn more

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