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Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow. 

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Maria Diaz-Meco headshot
Meet a Scientist

Maria Diaz-Meco, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

We are trying to better categorize tumor aggressiveness in order to help clinicians make more informed decisions about how to trea...

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

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Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

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Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

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Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

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Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Maria Diaz-Meco headshot
Meet a Scientist

Maria Diaz-Meco, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

We are trying to better categorize tumor aggressiveness in order to help clinicians make more informed decisions about how to trea...

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Disorders of Metabolism

The Center for Metabolic Origins of Disease studies common diseases that have reached pandemic scale including obesity, type 2 diabetes and cardiovascular complications. We have established an exciting environment that promotes multi-disciplinary discovery research toward breakthrough preventive and therapeutic strategies.

Learn more

Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the pathophysiologica...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, SBP Graduate School

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the gene...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Translational Medicine Accelerator

The TMA identifies and advances lab discoveries with the greatest potential to address unmet clinical needs.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and expertise to facilitate research.

SBP Pipeline - Current Projects

SBP Pipeline graphic
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Drug discovery projects

News

Sacco lab
In the News
February 12, 2018
Muscling up on stem cells
DDNEWS
Quantum dot
In the News
February 9, 2018
How quantum dots supercharge farming, medicine and solar, too
CNET
Rare disease
Beaker Blog February 6, 2018
Diagnosing a rare disease in children
Children born with the rare genetic disorder known as CDG often live for years before they receive a diagnosis. CDG—which stands for congenital disorders of gly...
Read more
Siobhan Malany, Ph.D.
In the News
February 6, 2018
R&D in Space: Medical Discoveries in Microgravity
R&D Magazine
Immunity logo
Paper of the Week
The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages
Alexey Terskikh Zika
Beaker Blog February 2, 2018
Off-the-shelf drugs could help manage Zika
The Zika virus has been relatively quiet lately, but that doesn’t mean the danger is over. Zika can come roaring back at any time, generating severe birth defec...
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AJHG logo
Paper of the Week
Biallelic mutations in FUT8 cause a congenital disorder of glycosylation with defective fucosylation
Padres Pedal
Beaker Blog January 26, 2018
Padres Pedal the Cause presents largest annual contribution to cancer research
Padres Pedal the Cause presented a check for $2,401,523.00 on Wednesday, January 24 to leaders from Sanford Burnham Prebys Medical Discovery Institute (SBP), Mo...
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Brain image
Press Release
January 24, 2018
Discovery may advance neural stem cell treatments for brain disorders
New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) is among the first to describe how an mRNA modification impacts the life of neural st...
Nature Neuroscience logo
Paper of the Week
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
Science logo
Paper of the Week
Recurrent infection progressively disables host protection against intestinal inflammation
most popular written on chalkboard
Beaker Blog January 9, 2018
Year in review: Top stories in 2017
In the last 12 months, SBP scientists published 338 scientific papers — that's almost a paper a day. We are proud of this impressive achievement, and equally pr...
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#1

Heart disease is the #1 killer around the globe. Find out how our groundbreaking research is working to change that. 

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Support us

We heart your heart. February is American Heart Month. Your support can help find innovative treatments for cardiovascular disease.

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