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Our path starts here

Join us on our journey as we drive scientific research to improve patient treatments for tomorrow.

Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

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Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of...

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

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Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

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huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only...

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Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Hudson Freeze profile photo
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)...

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, Graduate School of Biomedical Sciences

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the...

All Scientists
Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

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Cancer

The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.

Learn more

Francesca Marassi headshot
Meet a Scientist

Francesca Marassi, Ph.D.

Professor, Cancer Metabolism and Signaling Networks Program

Molecules are the building blocks of cellular life. Knowing their structures is key for understanding the basic mechanisms of...

All Scientists
Garth Powis D. Phil., headshot
Meet a Scientist

Garth Powis, D. Phil.

Jeanne and Gary Herberger Leadership Chair in Cancer Research

Dr. Powis studies the mechanisms that enable cancer cells to survive stress. 

All Scientists
Jamey Marth, Ph.D. standing in the lab
Meet a Scientist

Jamey Marth, Ph.D.

Professor, Tumor Microenvironment and Cancer Immunology Program

Dr. Marth's laboratory incorporates biology, engineering, and nanotechnologies to expand biomedical research capabilities.

All Scientists
Neuroscience and Aging

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.

Learn more

huaxi hu
Meet a Scientist

Huaxi Xu, Ph.D.

Jeanne and Gary Herberger Leadership Chair in Neuroscience Research

Dr. Xu's research efforts focus on understanding the molecular events that underlie the pathogenesis of Alzheimer's Disease.

All Scientists
Immunity

The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer. 

Learn more

Sumit Chanda profile photo
Meet a Scientist

Sumit Chanda, Ph.D.

Director and Professor, Immunity and Pathogenesis Program

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions, which will not only...

All Scientists
Carl Ware
Meet a Scientist

Carl F. Ware, Ph.D.

Director, Infectious and Inflammatory Diseases Center

Dr. Ware's research is directed at defining the intercellular communication pathways controlling immune responses.

All Scientists
Sanford Children's Health Research Center

Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

Learn more

Yu Yamaguchi headshot
Meet a Scientist

Yu Yamaguchi, M.D., Ph.D.

Professor, Human Genetics Program

Dr. Yamaguchi's studies the role of proteoglycans and glycosaminoglycans in the context of development and human disorders.

All Scientists
José Luis Millán, Ph.D. headshot
Meet a Scientist

José Luis Millán, Ph.D.

Professor, Human Genetics Program

Dr. Millán works on understanding the mechanisms that control normal skeletal mineralization and elucidating the...

All Scientists
Hudson Freeze profile photo
Meet a Scientist

Hudson Freeze, Ph.D.

Director and Professor, Human Genetics Program

Dr. Freeze’s research focuses on the pathology resulting from faulty glycosylation, the process of adding carbohydrate (sugar)...

All Scientists
Duc Dong, Ph.D., headshot
Meet a Scientist

Duc Dong, Ph.D.

Associate Dean of Admissions, Graduate School of Biomedical Sciences

Dr. Dong’s goal is to uncover fundamental insight into basic and biomedical science through the rigorous investigation of the...

All Scientists

Drug Discovery and Technology

SBP has the talent and resources to accelerate the development of new therapeutics.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

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Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

scientist and assay plate
Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

Pebys Center robot arm
Prebys Center

Through development and application of modern drug discovery technologies, SBP is uniquely positioned to make next-generation medicines.

slide in microscope
Shared Resources

Our cores provide advanced technology, expertise and instrumentation to investigators.

Pebys Center robot arm
Other Platforms

SBP innovates and maintains key technologies and partnerships to facilitate research.

SBP Pipeline - Current Projects

SBP Pipeline graphic
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Drug discovery projects

News

Sanford Burnham Prebys-Padres Pedal the Cause
Beaker Blog September 13, 2019
Sanford Burnham Prebys awarded Padres Pedal the Cause grants to advance cancer research
The collaborative projects aim to find new therapies for colorectal, lung, breast and prostate cancers.
Read more
Francesca Marassi, Ph.D., Sanford Burnham Prebys
Press Release
September 11, 2019
Solving long-sought protein structure opens new avenues for treating disease
Knowing the structure of vitronectin enables rational drug design
Molecular cell DNA
Beaker Blog September 10, 2019
How your DNA takes shape makes a big difference in your health
Sanford Burnham Prebys scientists use a cutting-edge genomic technology to shed light on this mystery.
Read more
molecular cell logo
Paper of the Week
Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation
tumor microenvironment
Beaker Blog September 3, 2019
Cancer’s final frontier: The tumor microenvironment
Experts explain why targeting the tumor’s surrounding environment could be the last piece of the cancer puzzle.
Read more
San Diego Union-Tribune Logo
In the News
August 27, 2019
No cure yet, but progress made in managing and detecting Alzheimer’s
The San Diego Union-Tribune
striated muscle fibers
Beaker Blog August 23, 2019
Sanford Burnham Prebys scientist receives NIH grant to boost heart muscle
The four-year grant totaling nearly two million dollars hopes to reduce the risk of heart attack.
Read more
Fleet Science Center-Garth Powis, Steven Snyder, Hatim Husain
Beaker Blog August 22, 2019
Fleet Science Center cancer series kicks off with lung cancer discussion
The panelists discussed newly available medicines—and the research advances that are on the horizon.
Read more
newborn baby feet
Press Release
August 19, 2019
$4.96 million CIRM grant awarded to Sanford Burnham Prebys to help the tiniest patients
The funding advances a stem cell therapy that may protect newborns from brain damage due to oxygen deprivation.
San Diego Business Journal logo
In the News
August 18, 2019
SBP and Eli Lilly extend collaboration for 3 more years
San Diego Business Journal
Lilly and Sanford Burnham Prebys logos
Press Release
August 14, 2019
Sanford Burnham Prebys expands collaboration with Lilly to investigate immunological therapies
Our state-of-the-art screening technologies—including a CRISPR-based platform—will be leveraged to accelerate drug discovery.
Professor Sumit Chanda, Ph.D.,  in the lab
Beaker Blog August 13, 2019
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the news of two treatments that saved the lives of people infected with the Ebola virus.
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5.7m

5.7 million Americans are living with Alzheimer’s. By 2050, this number is projected to rise to nearly 14 million. SBP research hopes to change that.

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