Our approach to improving human health is built on three principles:
Fundamental research. Our track record of pioneering research spans more than 40 years, and has produced breakthrough discoveries in cancer, neuroscience, immunology and rare children's diseases.
Translational research. We operate one of the most advanced drug discovery centers in the world that leverages biomedical discoveries to develop prototype drugs. And our deep culture of collaboration has attracted a global network of passionate partners.
Education and training. We're committed to education and training the next generation of scientific leaders to ensure our legacy continues.
Where independent minds come together
We are researching the pathways and signals that tumors use to reprogram their metabolism to escape normal cell death. Understanding these pathways helps identify therapeutic targets and is critical for the design of tumor-specific, less toxic therapies.
By deciphering the codes for normal development, aging and regeneration, we are gaining the tools to uncover novel therapeutics for patients with heart disease, neurodegeneration, muscle disorders, diabetes, cancer and other diseases associated with aging.
Our research is focused on the role and degradation of functional vs. nonfunctional protein. It appears that inappropriate 3-dimensional protein folding is a hallmark of degenerative diseases and deteriorates with environmental changes and age. Defective protein folding is increasingly thought to be associated with many diseases ranging from cancer to metabolic and inflammatory response syndromes.
We are probing the basis of genetic disease using zebrafish, mouse models, and stem cell technologies. We create “disease in a dish” models from a patient’s skin cells to study an individual’s specific genetic disorder, and apply the results to develop a personalized treatment strategy.
Our research is leading to the design of anti-viral compounds, vaccines, and new approaches to treat cancer. We are studying the complexities of the host immune system in inflammation, autoimmune and infectious diseases. In cancer, we are learning how to modulate the immune system to fight the growth and spread of tumors.
Our scientists study the types of cells that give rise to cancer and the molecular mechanisms they use to escape the normal cell cycle, including death. Their findings point the way to developing drugs that prohibit and inhibit tumor cell growth.
Understanding how cells interact with each other and their environment to promote tumor growth is a key step in combating cancer. We explore how the immune system is altered to promote tumor growth, and how we can harness the immune system to fight back and kill cancer cells.
Applying fundamental knowledge gained from our programs to specific diseases and technologies
The Institute’s Cancer Center is one of only seven NCI-designated basic cancer research centers in the nation. We couple fundamental biological research with early translational studies to find new, innovative therapies that restore hope to cancer patients and their families.
The human immune system is made up of a network of cells, tissues and organs that fight off disease. It can also turn against the body causing autoimmune disorders, such as rheumatoid arthritis, lupus, Crohn’s disease and psoriasis. Increasingly, scientists are learning how to help the body’s immune system to combat cancer.
Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast—to give one example, by 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million.
Genetic diseases in children are rare, and often incurable. Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.
Translation and Drug Discovery
Feeding the pipeline for the medicines of tomorrow
Our robust expertise and infrastructure—which includes one of the largest drug screening platforms in the nonprofit world—means we can quickly identify, test and deliver viable therapeutic candidates to our industry partners.
State-of-the-art Instrumentation, facilities and services
Sanford Burnham Prebys Medical Discovery Institute has an extensive Shared Resources system with over 20 core facilities. Their primary mission is to provide advanced technology, expertise and instrumentation to investigators that may not be easily acquired by individual laboratories.
The cores, staffed by technical experts, offer high quality interactive services that provide not only cost-effective sample analysis, but also assistance in experimental design, data analysis and grant or manuscript preparation. Many of the cores offer a choice of full service, or investigator training on their advanced instrumentation for independent use.
Our business development team can guide you to new opportunities.
A relationship with Sanford Burnham Prebys provides access to deep biological insights and cutting edge translational technology.
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