Infectious and Inflammatory Diseases Center

Center for Stem Cells and Regenerative Medicine

Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.

“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”

Carl Ware, Ph.D., Center Director

 

Understanding the fundamentals of inflammation and immunity

Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.

Program

Immunity and Pathogenesis Program

By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.

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Latest news

Publications

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS

Nat Med 2019 May ;25(5):805-813

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.

Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L

ACS Chem Biol 2019 May 17 ;14(5):949-958

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK

Nat Commun 2019 Apr 3 ;10(1):1523

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV

Nat Chem Biol 2020 Jun 29 ;

Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation.

Li X, Zhao J, Kasinath V, Uehara M, Jiang L, Banouni N, McGrath MM, Ichimura T, Fiorina P, Lemos DR, Shin SR, Ware CF, Bromberg JS, Abdi R

J Clin Invest 2020 Jun 29 ;

IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.

Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H

Gastroenterology 2020 Jun 20 ;

Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection.

Ojeda-Juárez D, Shah R, Fields JA, Harahap-Carrillo IS, Koury J, Maung R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M

Brain Behav Immun 2020 Jun 11 ;

Complete and Draft Genome Sequences of 12 Plant-Associated <i>Rathayibacter</i> Strains of Known and Putative New Species.

Tarlachkov SV, Starodumova IP, Dorofeeva LV, Prisyazhnaya NV, Leyn SA, Zlamal JE, Elane ML, Osterman AL, Nadler SA, Subbotin SA, Evtushenko LI

Microbiol Resour Announc 2020 May 28 ;9(22)

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.

Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ

Nat Neurosci 2020 Jul ;23(7):842-853

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