Sanford Burnham Prebys Cancer Center

One of only seven National Cancer Institute (NCI)-designated cancer centers in the nation.
NCI-Designated Cancer Center

Taking aim at cancer

“There have been so many advances in genomics, immunology, genetic engineering and information science—now is the time to use these advances to speed the progress against cancer.”

Garth Powis, D.Phil., Center Director

Director's Statement

 

Achieving our goals through collaboration

Our scientists are always looking for novel ideas, partners and new ways of doing groundbreaking research to target cancer.

Programs

Tumor Initiation and Maintenance Program

Understanding the cells that give rise to tumors and the signals allowing them to expand uncontrollably will help us learn how to defeat cancer.

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Cancer, Molecules and Structures Program

Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate will lead us to tumor-specific, less toxic therapies.

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Tumor Microenvironment and Cancer Immunology Program

We are studying the interplay among cancer cells, immune cells and their environment to put the brakes on cancer.
 

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Latest news

Cancer Center brochure

Learn more about the Cancer Center in our newly updated brochure.

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Publications

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.

Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK

Mol Cancer Ther 2019 May ;18(5):886-899

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C

PLoS Pathog 2019 Mar ;15(3):e1007667

Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.

Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA

Trends Mol Med 2019 May ;25(5):428-443

Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.

Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM

Nat Commun 2020 Jul 9 ;11(1):3502

Characterization of G-CSF receptor expression in medulloblastoma.

Paul MR, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya RJ, Zage PE

Neurooncol Adv 2020 Jan-Dec ;2(1):vdaa062

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.

Kim H, Kim H, Feng Y, Li Y, Tamiya H, Tocci S, Ronai ZA

Sci Transl Med 2020 Jul 8 ;12(551)

PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.

Brunner A, Suryo Rahmanto A, Johansson H, Franco M, Viiliäinen J, Gazi M, Frings O, Fredlund E, Spruck C, Lehtiö J, Rantala JK, Larsson LG, Sangfelt O

Elife 2020 Jul 6 ;9

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.

Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J

Cancer Cell 2020 Jun 9 ;

NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma.

Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ

Cell Rep 2020 Jun 23 ;31(12):107782

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