Taking aim at cancer
“There have been so many advances in genomics, immunology, genetic engineering and information science—now is the time to use these advances to speed the progress against cancer.”
– Garth Powis, D.Phil., Center Director
Tumor Initiation and Maintenance Program
Understanding the cells that give rise to tumors and the signals allowing them to expand uncontrollably will help us learn how to defeat cancer.
Cancer, Molecules and Structures Program
Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate will lead us to tumor-specific, less toxic therapies.
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.
Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK
Mol Cancer Ther 2019 May ;18(5):886-899
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS Pathog 2019 Mar ;15(3):e1007667
Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA
Trends Mol Med 2019 May ;25(5):428-443