Sanford Burnham Prebys Cancer Center

One of only seven National Cancer Institute (NCI)-designated cancer centers in the nation.
NCI-Designated Cancer Center

Taking aim at cancer

“There have been so many advances in genomics, immunology, genetic engineering and information science—now is the time to use these advances to speed the progress against cancer.”

- Garth Powis, D.Phil., Center Director

Director's Statement

 

Achieving our goals through collaboration

Our scientists are always looking for novel ideas, partners and new ways of doing groundbreaking research to target cancer.

Programs

Tumor Initiation and Maintenance Program

Understanding the cells that give rise to tumors and the signals allowing them to expand uncontrollably will help us learn how to defeat cancer.

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Cancer Metabolism and Signaling Networks Program

Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate will lead us to tumor-specific, less toxic therapies.

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Tumor Microenvironment and Cancer Immunology Program

We are studying the interplay among cancer cells, immune cells and their environment to put the brakes on cancer.
 

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Latest news

Cancer Center brochure

Learn more about the Cancer Center in our newly updated brochure.

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Publications

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.

Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK

Mol Cancer Ther 2019 May ;18(5):886-899

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C

PLoS Pathog 2019 Mar ;15(3):e1007667

Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.

Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA

Trends Mol Med 2019 May ;25(5):428-443

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Neuron 2019 Aug 26 ;

Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation.

Dall'Agnese A, Caputo L, Nicoletti C, di Iulio J, Schmitt A, Gatto S, Diao Y, Ye Z, Forcato M, Perera R, Bicciato S, Telenti A, Ren B, Puri PL

Mol Cell 2019 Aug 20 ;

Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness.

Sabelström H, Petri R, Shchors K, Jandial R, Schmidt C, Sacheva R, Masic S, Yuan E, Fenster T, Martinez M, Saxena S, Nicolaides TP, Ilkhanizadeh S, Berger MS, Snyder EY, Weiss WA, Jakobsson J, Persson AI

Cell Rep 2019 Aug 20 ;28(8):2064-2079.e11

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance.

Goldman A, Khiste S, Freinkman E, Dhawan A, Majumder B, Mondal J, Pinkerton AB, Eton E, Medhi R, Chandrasekar V, Rahman MM, Ichimura T, Gopinath KS, Majumder P, Kohandel M, Sengupta S

Sci Signal 2019 Aug 20 ;12(595)

Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM

Nat Commun 2019 Aug 13 ;10(1):3644

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.

Costa TDF, Zhuang T, Lorent J, Turco E, Olofsson H, Masia-Balague M, Zhao M, Rabieifar P, Robertson N, Kuiper R, Sjölund J, Spiess M, Hernández-Varas P, Rabenhorst U, Roswall P, Ma R, Gong X, Hartman J, Pietras K, Adams PD, Defilippi P, Strömblad S

Nat Commun 2019 Aug 9 ;10(1):3589

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