Sanford Burnham Prebys Cancer Center

One of only seven National Cancer Institute (NCI)-designated cancer centers in the nation.
NCI-Designated Cancer Center

Taking aim at cancer

“There have been so many advances in genomics, immunology, genetic engineering and information science—now is the time to use these advances to speed the progress against cancer.”

Garth Powis, D.Phil., Center Director

Director's Statement

 

Achieving our goals through collaboration

Our scientists are always looking for novel ideas, partners and new ways of doing groundbreaking research to target cancer.

Programs

Tumor Initiation and Maintenance Program

Understanding the cells that give rise to tumors and the signals allowing them to expand uncontrollably will help us learn how to defeat cancer.

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Cancer Metabolism and Signaling Networks Program

Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate will lead us to tumor-specific, less toxic therapies.

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Tumor Microenvironment and Cancer Immunology Program

We are studying the interplay among cancer cells, immune cells and their environment to put the brakes on cancer.
 

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Latest news

Cancer Center brochure

Learn more about the Cancer Center in our newly updated brochure.

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Publications

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.

Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK

Mol Cancer Ther 2019 May ;18(5):886-899

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.

McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C

PLoS Pathog 2019 Mar ;15(3):e1007667

Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.

Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA

Trends Mol Med 2019 May ;25(5):428-443

Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney.

Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP

J Clin Invest 2020 Feb 17 ;

Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue.

Lee JH, Go Y, Kim DY, Lee SH, Kim OH, Jeon YH, Kwon TK, Bae JH, Song DK, Rhyu IJ, Lee IK, Shong M, Oh BC, Petucci C, Park JW, Osborne TF, Im SS

Exp Mol Med 2020 Feb 3 ;

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.

Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, Perez-Garcia A, Kiourtis C, Dasgupta N, Lei X, Kruger PJ, Nixon C, Clark W, Jurk D, Bird TG, Passos JF, Berger SL, Dou Z, Adams PD

Genes Dev 2020 Jan 30 ;

Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.

Virgen-Slane R, Correa RG, Ramezani-Rad P, Steen-Fuentes S, Detanico T, DiCandido MJ, Li J, Ware CF

J Immunol 2020 Mar 1 ;204(5):1085-1090

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α<sub>v</sub>β<sub>5</sub> Axis.

Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN

Cell Stem Cell 2020 Feb 6 ;26(2):187-204.e10

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT

Br J Cancer 2020 Jan 16 ;

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