Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast.
By 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million. Our researchers are discovering the etiological pathways as well as small-molecule and stem cell-based treatments to address the clinical unmet need of patients.
Degenerative Diseases Program
Every degenerative disease is associated with misfolded proteins. Studying these proteins provides new clues to protecting our health.
Development, Aging and Regeneration Program
By building, analyzing and probing models of disease, we can pursue innovative treatment strategies for challenging health conditions.
This Institute-wide effort brings researchers together to apply multi-disciplinary approaches to understand cellular and molecular processes that underlie neurodegenerative diseases.
Raices M, D'Angelo MA
Neuron 2019 May 8 ;102(3):509-511
Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.
Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM
J Clin Med 2019 May 6 ;8(5)
Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A
Cell 2019 May 2 ;177(4):881-895.e17
Zhou J, Chow HM, Liu Y, Wu D, Shi M, Li J, Wen L, Gao Y, Chen G, Zhuang K, Lin H, Zhang G, Xie W, Li H, Leng L, Wang M, Zheng N, Sun H, Zhao Y, Zhang Y, Xue M, Huang TY, Bu G, Xu H, Yuan Z, Herrup K, Zhang J
Biol Psychiatry 2019 Nov 21 ;
Zhang F, Gannon M, Chen Y, Yan S, Zhang S, Feng W, Tao J, Sha B, Liu Z, Saito T, Saido T, Keene CD, Jiao K, Roberson ED, Xu H, Wang Q
Sci Transl Med 2020 Jan 15 ;12(526)
Plasma levels of Interleukin 18 but not amyloid-β or Tau are elevated in female depressive patients.
Liu FR, Yang LY, Zheng HF, Zhou Y, Chen BB, Xu H, Zhang YW, Shen DY
Compr Psychiatry 2020 Feb ;97:152159
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.
Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X
PLoS Biol 2019 Dec ;17(12):e3000525
Jia L, Piña-Crespo J, Li Y
Mol Brain 2019 Dec 4 ;12(1):104
Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling.
Liu Y, Wang S, Kan J, Zhang J, Zhou L, Huang Y, Zhang Y
Curr Neuropharmacol 2019 Nov 1 ;