Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast.
By 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million. Our researchers are discovering the etiological pathways as well as small-molecule and stem cell-based treatments to address the clinical unmet need of patients.
Degenerative Diseases Program
Every degenerative disease is associated with misfolded proteins. Studying these proteins provides new clues to protecting our health.
Development, Aging and Regeneration Program
By building, analyzing and probing models of disease, we can pursue innovative treatment strategies for challenging health conditions.
This Institute-wide effort brings researchers together to apply multi-disciplinary approaches to understand cellular and molecular processes that underlie neurodegenerative diseases.
Raices M, D'Angelo MA
Neuron 2019 May 8 ;102(3):509-511
Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.
Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM
J Clin Med 2019 May 6 ;8(5)
Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A
Cell 2019 May 2 ;177(4):881-895.e17
Jia L, Piña-Crespo J, Li Y
Mol Brain 2019 Dec 4 ;12(1):104
Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling.
Liu Y, Wang S, Kan J, Zhang J, Zhou L, Huang Y, Zhang Y
Curr Neuropharmacol 2019 Nov 1 ;
Zhang C, Tan Z, Xie Y, Zhao Y, Huang TY, Lu Z, Luo H, Can D, Xu H, Zhang YW, Zhang X
Front Aging Neurosci 2019 ;11:243
SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse.
Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW, Zhang X
Front Cell Neurosci 2019 ;13:410
Huang TY, Xu H
Neuron 2019 Sep 4 ;103(5):747-749
Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, Yao Y, Zhang YW
Exp Mol Med 2019 Jul 23 ;51(7):84