Disease and the immune response
Pathogenesis—literally how disease (pathos) begins (genesis) or develops—is a broad and important area of research.
Many diseases can arise from pathogens, but the immune system protects us through various lines of defense. If the immune system fails to function properly and becomes too weak or too strong, it can lead to disease states that include immunodeficiencies that lead to enhanced susceptibly to infections disease, autoimmune conditions, such as lupus and arthritis, and even cancer.
Our focus is on understanding the regulation and interplay of host immune responses and microbial pathogenesis. We study pathogen-host interactions, innate and humoral immunity, inflammation and T cell checkpoint regulation. A better understanding of these aspects of the immune system will provide novel therapeutic opportunities to address many unmet medical needs, including the treatment of endemic and pandemic infectious diseases, autoimmune disorders, cancer and inflammatory diseases.
Ware CF, Croft M, Neil GA
J Exp Med 2022 Jul 4 ;219(7)
Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.
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Front Cell Dev Biol 2022 ;10:979096
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Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.
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Front Immunol 2021 ;12:773445