Immunity and Pathogenesis Program

lymph node with abscess; image from NIH Image Gallery

Disease and the immune response

Pathogenesis—literally how disease (pathos) begins (genesis) or develops—is a broad and important area of research.

Many diseases can arise from pathogens, but the immune system protects us through various lines of defense. If the immune system fails to function properly and becomes too weak or too strong, it can lead to disease states that include immunodeficiencies that lead to enhanced susceptibly to infections disease, autoimmune conditions, such as lupus and arthritis, and even cancer. 

Director's statement

Our focus is on understanding the regulation and interplay of host immune responses and microbial pathogenesis. We study viral-host interactions, innate and humoral immunity, inflammation and T cell checkpoint regulation. A better understanding of these aspects of the immune system will provide novel therapeutic opportunities to address many unmet medical needs, including the treatment of endemic and pandemic infectious diseases, autoimmune disorders, cancer and inflammatory diseases.

Sumit Chanda, Ph.D., Program Director

Appointments

Publications

SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway.

Verma S, De Jesus P, Chanda SK, Verma IM

Mol Cell Biol 2019 Feb 1 ;39(3)

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD

Cell Host Microbe 2018 Oct 10 ;24(4):500-513.e5

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.

Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J

Immunity 2018 Dec 18 ;49(6):1132-1147.e7

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.

Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C

MBio 2019 Aug 27 ;10(4)

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK

Nat Commun 2019 Apr 3 ;10(1):1523

Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies.

Majer C, Schüssler JM, König R

Med Microbiol Immunol 2019 Aug ;208(3-4):513-529

Electron cryo-tomography of vestibular hair-cell stereocilia.

Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M

J Struct Biol 2019 May 1 ;206(2):149-155

Does self-organized criticality drive leading edge protrusion?

Anderson KL, Swift MF, Hanein D, Volkmann N

Biophys Rev 2018 Dec ;10(6):1571-1575

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C

J Virol 2018 Oct 15 ;92(20)

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