Disease and the immune response
Pathogenesis—literally how disease (pathos) begins (genesis) or develops—is a broad and important area of research.
Many diseases can arise from pathogens, but the immune system protects us through various lines of defense. If the immune system fails to function properly and becomes too weak or too strong, it can lead to disease states that include immunodeficiencies that lead to enhanced susceptibly to infections disease, autoimmune conditions, such as lupus and arthritis, and even cancer.
Director's statement
Our focus is on understanding the regulation and interplay of host immune responses and microbial pathogenesis. We study viral-host interactions, innate and humoral immunity, inflammation and T cell checkpoint regulation. A better understanding of these aspects of the immune system will provide novel therapeutic opportunities to address many unmet medical needs, including the treatment of endemic and pandemic infectious diseases, autoimmune disorders, cancer and inflammatory diseases.
– Sumit Chanda, Ph.D., Program Director
Appointments
Program Director
Primary Appointments
Victoria Blaho, Ph.D.
Andrei Osterman, Ph.D.
Carl F. Ware, Ph.D.
Adjunct Appointments
Publications
Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.
Virgen-Slane R, Correa RG, Ramezani-Rad P, Steen-Fuentes S, Detanico T, DiCandido MJ, Li J, Ware CF
J Immunol 2020 Mar 1 ;204(5):1085-1090
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Hilliard KA, Blaho VA, Jackson CD, Brown CR
FASEB J 2020 Feb ;34(2):2840-2852
Identifying determinants of bacterial fitness in a model of human gut microbial succession.
Feng L, Raman AS, Hibberd MC, Cheng J, Griffin NW, Peng Y, Leyn SA, Rodionov DA, Osterman AL, Gordon JI
Proc Natl Acad Sci U S A 2020 Feb 4 ;117(5):2622-2633
Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes.
Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR, Liese J, Hornung V, Urban S, König R
Viruses 2020 May 29 ;12(6)
Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.
Poothong J, Pottekat A, Siirin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ
Blood 2020 May 21 ;135(21):1899-1911
Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1).
Fuchs NV, Schieck M, Neuenkirch M, Tondera C, Schmitz H, Wendeburg L, Steinemann D, Elpers C, Rutsch F, König R
Stem Cell Res 2020 Mar ;43:101697
Sensor Sensibility-HIV-1 and the Innate Immune Response.
Yin X, Langer S, Zhang Z, Herbert KM, Yoh S, König R, Chanda SK
Cells 2020 Jan 20 ;9(1)
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Hilliard KA, Blaho VA, Jackson CD, Brown CR
FASEB J 2020 Feb ;34(2):2840-2852