The tumor microenvironment is filled with noncancerous cells and molecules that are nevertheless an integral part of cancer.
Some tumors hijack these neighbors to help build physical walls around themselves. Many trick the microenvironment to help grow new blood vessels to supply them with energy. Tumors can also fool the immune system to escape detection, and can even mobilize immune cells to promote their growth.
We are exploring how the interplay between cancer cells, the microenvironment and immune cells regulates the growth and metastasis of solid and hematologic malignancies. Our program members have diverse interests including the microbiome, cell migration/invasion, cell signaling, angiogenesis and immunology; and are highly collaborative, generating new ideas and fresh angles to treat cancer.
– Linda Bradley, Ph.D., Program Director
Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA
Oncotarget 2016 Nov 29 ;7(48):78473-78486
Jellusova J, Rickert RC
Crit Rev Biochem Mol Biol 2016 Sep ;51(5):359-378
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M
Nature 2016 Oct 20 ;538(7625):350-355
Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.
Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH
Cell Rep 2020 Jun 30 ;31(13):107839
Dietary Emulsifier Sodium Stearoyl Lactylate Alters Gut Microbiota <i>in vitro</i> and Inhibits Bacterial Butyrate Producers.
Elmén L, Zlamal JE, Scott DA, Lee RB, Chen DJ, Colas AR, Rodionov DA, Peterson SN
Front Microbiol 2020 ;11:892
Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ
Nat Neurosci 2020 Jul ;23(7):842-853
Ramezani-Rad P, Leung CR, Apgar JR, Rickert RC
J Immunol 2020 Mar 15 ;204(6):1535-1542
Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor.
Cattaneo P, Mukherjee D, Spinozzi S, Zhang L, Larcher V, Stallcup WB, Kataoka H, Chen J, Dimmeler S, Evans SM, Guimarães-Camboa N
Cell Rep 2020 Jan 14 ;30(2):571-582.e2
Zhu Z, Shukla A, Ramezani-Rad P, Apgar JR, Rickert RC
Life Sci Alliance 2019 Dec ;2(6)