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In these unprecedented times, Sanford Burnham Prebys scientists are fiercely pursuing research to minimize today’s impact of SARS-CoV-19 and prepare for the pandemics of tomorrow.
Solutions for TODAY
We are in urgent need of medications to treat COVID-19.
Dr. Chanda has screened thousands of existing, safe drugs to identify those that stop viral replication and could be rapidly be repurposed as a treatment. Thirty drugs that show promise are under further investigation.
Dr. Ronai is studying the interactions between the virus and proteins within our cells. The work is revealing human host cell proteins that may serve as drug targets. His team is also analyzing 18 small molecules that appear to stop the virus from hijacking our cell machinery to make copies of itself.
Dr. Terskikh is leading a collaboration with UC San Diego and La Jolla Institute for Immunology to create drug combinations that inhibit the enzymes used to make viral proteins and restore the immune response to levels that inhibit the virus.
Planning for TOMORROW
For future pandemics, we’re re-thinking strategy.
Dr. Chanda is working on broad spectrum antiviral drugs that can be used against a wide variety of respiratory viruses. The Department of Defense has already funded $10M to help provide the nation with safe, effective and innovative therapies
Dr. Itkin-Ansari is studying the biological reasons why people with diabetes have a higher risk of severe disease than others. The answers may lead to tailored preventions and treatments.
Dr. Snyder is testing the effects of drug candidates in human lung “organoids” developed from human stem cells. The work will help us understand how the virus infects and reproduces in lung cells, and can help explain why some infected people fare worse than others.