Combining MDM2 and BET inhibition produces a "double whammy" effect in acute myeloid leukemia by activating p53 via two different pathways, a new study found.
"For the first time, we can see the cellular and molecular changes that may underlie the heart conditions seen in astronaut studies," said Karen Ocorr, co-senior author of the study.
Molecular changes in cells called fibroblasts may explain why one type of colon cancer doesn’t respond to therapy, according to a new study by Drs. Jorge Moscat-Guillen and Maria Diaz-Meco, adjunct professors at Sanford Burnham Prebys.