The glucocorticoid receptor (GR) is a member of the nuclear receptor super-familyof transcription factors. Some GR chaperones have been genetically linked to mooddisorders, PTSD and actions of mood stabilizers. Further, the most well characterized GR polymorphisms support a positive association between reduced GC sensitivity and beneficial metabolic and cognitive effects. The objective of the GRprogram is to develop antagonists of the HPA Axis and Inflammatory
PCT WO 2016123392 “Pyrazolopyridines as inhibitors of glucocorticoid receptor translocation” Pinkerton, A. B.; Hassig, C. A.; Jackson, M. R.; Ardecky, R. J.; Pass, I.