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Prebys Center

Allosteric Inhibitors of LMPTP Research Program

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling.  As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a promising drug target for insulin resistance and related conditions. Inhibitors developed at the Prebys Center, incollaboration with Dr. Nunzio Bottini currently at UC San Diego, have the potential for therapeutic development for the treatment of obesity-associated insulin resistance and heart failure.

 

Patents

PCT WO 2016061280 “Inhibitors of low molecular weight protein tyrosinephosphatase and uses thereof” Anthony B. Pinkerton, Thomas Chung, MichaelHedrick, Robert John Ardecky, Nunzio Bottini, Jiwen Zou, Santhi R. Ganji, Stephanie Stanford, Kenneth E. Jenkins

Grant

Small Molecule Inhibitors of LMPTP: An Obesity Drug Target, R01 Collaboration with Nunzio Bottini of UC San Diego and Anthony Pinkerton of SBP

Small Molecule Inhibitors of LMPTP: An Obesity Target, R03 Collaboration with Nunzio Bottini of UC San Diego and the Conrad Prebys Center for Chemical Genomics