beakers drying on wall

Prebys Center

Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase 6-Phosphogluconolactonase Research Program

Glucose-6-phosphate dehydrogenase (G6PD) is a novel target for antimalarial drug design based on observations that humans with a deficiency in this enzyme are protected from malaria. Working together with Lars Bode, of the University ofCalifornia, we are investigating the development of novel antimalarial drugs, which induce the same resistance in people who do not naturally have deficiencies inG6PD.

 

Grant

Selective Inhibitors of Plasmodium Falciparum G6PD as Novel Antimalarials, Collaboration with Lars Bode of UC San Diego and Anthony Pinkerton of SBP

Identification of G6PD inhibitors for the development of novel antimalarial drugs, Collaboration with Lars Bode of UC San Diego and Edaurd Sergienko of SBP

Publications

Maloney P, Hedrick M, Peddibhotla S, Hershberger P, Milewski M, Gosalia P, Li L, Preuss J, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Salanawil S, Stonich D, Su Y, Dahl R, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth G, Diwan J, Chung TDY, Pinkerton AB, Bode L, Becker K
2010;
Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TD, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L
J Med Chem 2012 Aug 23;55(16):7262-72
Preuss J, Richardson AD, Pinkerton A, Hedrick M, Sergienko E, Rahlfs S, Becker K, Bode L
J Biomol Screen 2013 Mar;18(3):286-97