beakers drying on wall

Prebys Center

TNAP Research Program

Medial vascular calcification causes generalized arterial calcification of infancy, a severe childhood disease, and is an increasingly recognized problem in patients with diabetes, chronic kidney disease and other serious conditions. Calcification is associated with significant morbidity and mortality in these diseases and currently there are no effective treatments. Our TNAP research program investigated the pathophysiological and therapeutic role of this phosphatase.



PCT WO 2013126608 “Sulfonamide Compounds and Uses of TNAP Inhibitors” Pinkerton, A. B.; Dahl, R.; Cosford, N. D. P.; Millan, J. L.

PCT WO 2016054056 “Methods of treating PXE with TNAP Inhibitors” Gahl, W. A.;Ziegler, S. G.; Dietz, H. C.; Pinkerton, A. B.; Millan, J. L.


Lead Optimization of Novel Inhibitors of Tissue Non-specific Alkaline Phosphatase, Collaboration with Nick Cosford and Jose Luis Millan


Chan X, Brown B, Hedrick M, Rascon J, Millán JL, Sergienko E, Roth G, Reddy S, Dad S, Chung TDY, Cosford N, Stonich D, Su Y
Sheen CR, Kuss P, Narisawa S, Yadav MC, Nigro J, Wang W, Chhea TN, Sergienko EA, Kapoor K, Jackson MR, Hoylaerts MF, Pinkerton AB, O'Neill WC, Millán JL
J Bone Miner Res 2015 May;30(5):824-36
Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TD, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL
Bioorg Med Chem Lett 2014 Feb 1;24(3):1000-4