What is the focus of our program — what questions are we asking?
The SBP Neuroscience Initiative (SBPNI) integrates institution-wide research on neuroscience and is focused on deepening the understanding of the cellular and molecular basis of brain homeostasis and disease-causing processes in brain. Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease-relevant targets that can be harnessed to drive drug discovery efforts in neurological and age-related neurodegenerative diseases. In an effort to achieve these goals, we have established interdisciplinary partnerships devoted to the study of basic biological processes and signaling pathways targeted by neurodegeneration in Alzheimer’s and Parkinson’s disease, tauopathies, Down syndrome, neurometabolic disease (including obesity & diabetes), motor neuron disease and traumatic brain injury.
How will our research help patients?
Combined understanding of healthy brain functions and disruptions in neurological disease places Neuroscience laboratories at SBP at the forefront of knowledge to identify disease-relevant targets and design screens for promising new drugs that can slow, halt or prevent the progression of neurological disorders. Our goal is to kick-start the drug discovery process as early as possible by removing translational delays in the transition of drug development from bench to bedside. Working with SBP's Conrad Prebys Center for Chemical Genomics, we are uniquely positioned for the state-of-art drug discovery process with world-class experts in pharmaceutical and biotech drug discovery.
- Feb 16, 2017
Treating Alzheimer’s by stimulating the brain’s rubbish collectors
- Dec 12, 2016
Research identifies a molecular basis for common congenital brain defect
- Dec 9, 2016
Leading Alzheimer's scientist moves from TSRI to Sanford Burnham Prebys
- Nov 22, 2016
Huaxi Xu, Ph.D., Named the Jeanne and Gary Herberger Chair in Neuroscience at SBP
- Oct 18, 2016
Cure Alzheimer’s Awards Over $700,000 to Support 5 Research Efforts
- Jun 23, 2016
New Technology Could Deliver Drugs to Brain Injuries
- Jan 17, 2016
Alzheimer's advances on the horizon
- Sep 2, 2015
Brain degeneration trigger related to Alzheimer's found
- May 3, 2016
SBP team supports multiple sclerosis research at Walk MS
- May 21, 2015
Q & A with MS Patient Advocate Denise Boucher
- March 15, 2015
Multiple Sclerosis Society names Sanford Burnham's Dr. Barbara Ranscht as Researcher of the year
- Jan 6, 2014
Paper of the week: Contactin-1 regulates myelination