Alexandre Colas, Ph.D.

Alexandre Colas' Research Focus

Heart Disease, Cardiovascular Diseases, Cardiomyopathies
Development and Differentiation, Embryonic/Pluripotent Stem Cells, Cardiovascular Biology, Regenerative Biology, Transcription Factors, RNA-Based Gene Regulation, Embryogenesis, Cell Biology

Our laboratory focuses on the identification and reconstruction of novel regulatory pathways controlling the determination and the acquisition of cardiovascular cell fates in humans. To that end, our team has developed a unique set of cell-based assays suitable for high-throughput functional screening, which enables the implementation of unbiased and systematic experimental approaches with unprecedented exploratory power. Our goal is to leverage generated knowledge to produce better cardiomyocytes to model cardiac diseases in-a-dish as well as to devise innovative cardiac regenerative strategies. In parallel, our lab is also dedicated to identify and develop new drugs promoting cardiac regeneration and/or helping preserving heart function after injury.

Alexandre Colas' Bio

Dr. Colas earned his Ph.D. from the Universite Pierre et Marie Curie, Paris, France.
 

Funding Awards and Collaborative Grants

2011-2013: American Heart Association Post-Doctoral Fellowship
2011: Best Talk Award (Development & Aging Post-Doctoral Retreat, SBP)
2010-2011: California Institute for Regenerative Medicine Post-Doctoral Fellowship
2006-2007: French Myopathy Association Ph.D. Fellowship
2003-2006: Ministry of French Research Ph.D. Fellowship
2000-2001: Erasmus Undergraduate Fellowship


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Publications

Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.

Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G

PLoS One 2015 ;10(9):e0137894

Induced pluripotent stem cells in cardiovascular drug discovery.

Mercola M, Colas A, Willems E

Circ Res 2013 Feb 1 ;112(3):534-48

Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening.

McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M

Curr Protoc Stem Cell Biol 2012 Nov ;Chapter 1:Unit 1F.13

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AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes.

Bruyneel AAN, Colas AR, Karakikes I, Mercola M

PLoS One 2019 ;14(12):e0226694

Model system identification of novel congenital heart disease gene candidates: focus on RPL13.

Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld JA, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R

Hum Mol Genet 2019 Dec 1 ;28(23):3954-3969

Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors.

El Harane N, Kervadec A, Bellamy V, Pidial L, Neametalla HJ, Perier MC, Lima Correa B, Thiébault L, Cagnard N, Duché A, Brunaud C, Lemitre M, Gauthier J, Bourdillon AT, Renault MP, Hovhannisyan Y, Paiva S, Colas AR, Agbulut O, Hagège A, Silvestre JS, Menasché P, Renault NKE

Eur Heart J 2018 May 21 ;39(20):1835-1847

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.

McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M

Front Physiol 2017 ;8:766

Id genes are essential for early heart formation.

Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR

Genes Dev 2017 Jul 1 ;31(13):1325-1338

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