Alexandre Colas' Research Focus
Our laboratory focuses on the identification and reconstruction of novel regulatory pathways controlling the determination and the acquisition of cardiovascular cell fates in humans. To that end, our team has developed a unique set of cell-based assays suitable for high-throughput functional screening, which enables the implementation of unbiased and systematic experimental approaches with unprecedented exploratory power. Our goal is to leverage generated knowledge to produce better cardiomyocytes to model cardiac diseases in-a-dish as well as to devise innovative cardiac regenerative strategies. In parallel, our lab is also dedicated to identify and develop new drugs promoting cardiac regeneration and/or helping preserving heart function after injury.
Alexandre Colas' Bio
Dr. Colas earned his Ph.D. from the Universite Pierre et Marie Curie, Paris, France.
Funding Awards and Collaborative Grants
2011-2013: American Heart Association Post-Doctoral Fellowship
2011: Best Talk Award (Development & Aging Post-Doctoral Retreat, SBP)
2010-2011: California Institute for Regenerative Medicine Post-Doctoral Fellowship
2006-2007: French Myopathy Association Ph.D. Fellowship
2003-2006: Ministry of French Research Ph.D. Fellowship
2000-2001: Erasmus Undergraduate Fellowship
Publications
Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G
PLoS One 2015 ;10(9):e0137894
Induced pluripotent stem cells in cardiovascular drug discovery.
Mercola M, Colas A, Willems E
Circ Res 2013 Feb 1 ;112(3):534-48
Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening.
McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M
Curr Protoc Stem Cell Biol 2012 Nov ;Chapter 1:Unit 1F.13
Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes.
Kannan S, Miyamoto M, Zhu R, Lynott M, Guo J, Chen EZ, Colas AR, Lin BL, Kwon C
Cell Rep 2023 Apr 3 ;42(4):112330
Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells.
Missinato MA, Murphy S, Lynott M, Yu MS, Kervadec A, Chang YL, Kannan S, Loreti M, Lee C, Amatya P, Tanaka H, Huang CT, Puri PL, Kwon C, Adams PD, Qian L, Sacco A, Andersen P, Colas AR
Nat Commun 2023 Mar 27 ;14(1):1709
Genetic architecture of natural variation of cardiac performance from flies to humans.
Saha S, Spinelli L, Castro Mondragon JA, Kervadec A, Lynott M, Kremmer L, Roder L, Krifa S, Torres M, Brun C, Vogler G, Bodmer R, Colas AR, Ocorr K, Perrin L
Elife 2022 Nov 16 ;11
Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling.
Schroeder AM, Nielsen T, Lynott M, Vogler G, Colas AR, Bodmer R
PLoS Genet 2022 Oct ;18(10):e1010448
Atrial Fibrillation Genomics: Discovery and Translation.
Yoo DH, Bodmer R, Ocorr K, Larson CJ, Colas AR, Muse ED
Curr Cardiol Rep 2021 Oct 1 ;23(11):164
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C
Nat Commun 2021 Mar 12 ;12(1):1648
