Alexey Terskikh, Ph.D.

Alexey Terskikh's Research Focus

Brain Cancer, Breast Cancer, Parkinson's Disease

During development and in many adult tissues, stem cells are capable of self-renewal or differentiation depending on the extrinsic signals provided by the surrounding microenvironment (e.g., the stem cell niche). Many cancers are thought to be maintained by cancer initiating cells (sometimes called cancer stem cells), which often hijack stem cell self-renewal mechanisms. The Terskikh laboratory is interested in elucidating the molecular and cellular mechanisms underlying self-renewing and differentiation decisions using neural stem cells as a model, in particularly studying how this knowledge can be used to fight cancer.

Alexey Terskikh's Bio

Alexey Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996, in the laboratory of Prof. J.P. Mach, where he designed a new type of high-avidity recombinant molecule called Peptabody. He received postdoctoral training with Prof. Irving Weissman at Stanford University, where he discovered a common genetic program between hematopoietic and neural stem cells. Dr. Terskikh holds an Assistant Professor position in the Brain and Mind Institute at EPFL in Lausanne, Switzerland (2002-2006) and was recruited to SBP as Adjunct Assistant Professor in 2002 and as a full time Assistant Professor in 2006.


DAR Accessory

Publications

Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory.

Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV

J Neurosci 2011 Jul 6 ;31(27):9933-44

Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis.

Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV

Cell Stem Cell 2011 May 6 ;8(5):538-51

Early acquisition of neural crest competence during hESCs neuralization.

Curchoe CL, Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder EY, Bronner-Fraser M, Terskikh AV

PLoS One 2010 Nov 9 ;5(11):e13890

Show All Select Publications

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.

Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG

Neuron 2019 Mar 20 ;101(6):1089-1098.e4

Zika Virus: Origins, Pathological Action, and Treatment Strategies.

Gorshkov K, Shiryaev SA, Fertel S, Lin YW, Huang CT, Pinto A, Farhy C, Strongin AY, Zheng W, Terskikh AV

Front Microbiol 2018 ;9:3252

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W

Cell Discov 2018 ;4:31

Author Correction: Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR

Sci Rep 2018 Jun 5 ;8(1):8794

Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR

Sci Rep 2018 Jan 19 ;8(1):1218

Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.

Shiryaev SA, Mesci P, Pinto A, Fernandes I, Sheets N, Shresta S, Farhy C, Huang CT, Strongin AY, Muotri AR, Terskikh AV

Sci Rep 2017 Nov 17 ;7(1):15771

Show All Publications