Alexey Terskikh's Research Focus
During development and in many adult tissues, stem cells are capable of self-renewal or differentiation depending on the extrinsic signals provided by the surrounding microenvironment (e.g., the stem cell niche). Many cancers are thought to be maintained by cancer initiating cells (sometimes called cancer stem cells), which often hijack stem cell self-renewal mechanisms. The Terskikh laboratory is interested in elucidating the molecular and cellular mechanisms underlying self-renewing and differentiation decisions using neural stem cells as a model, in particularly studying how this knowledge can be used to fight cancer.
Alexey Terskikh's Bio
Alexey Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996, in the laboratory of Prof. J.P. Mach, where he designed a new type of high-avidity recombinant molecule called Peptabody. He received postdoctoral training with Prof. Irving Weissman at Stanford University, where he discovered a common genetic program between hematopoietic and neural stem cells. Dr. Terskikh holds an Assistant Professor position in the Brain and Mind Institute at EPFL in Lausanne, Switzerland (2002-2006) and was recruited to Sanford Burnham Prebys as Adjunct Assistant Professor in 2002 and as a full time Assistant Professor in 2006.
Terskikh A, Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P
Science 2000 Nov 24 ;290(5496):1585-8
Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV
Cell Stem Cell 2011 May 6 ;8(5):538-51
SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, Terskikh AV
Proc Natl Acad Sci U S A 2015 Apr 14 ;112(15):E1936-45
ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
Lin L, Pinto A, Wang L, Fukatsu K, Yin Y, Bamforth SD, Bronner ME, Evans SM, Nie S, Anderson RH, Terskikh AV, Grossfeld PD
Hum Mol Genet 2022 Jul 28 ;
A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity.
Regla-Nava JA, Wang YT, Fontes-Garfias CR, Liu Y, Syed T, Susantono M, Gonzalez A, Viramontes KM, Verma SK, Kim K, Landeras-Bueno S, Huang CT, Prigozhin DM, Gleeson JG, Terskikh AV, Shi PY, Shresta S
Cell Rep 2022 Apr 12 ;39(2):110655
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells.
Smith AS, Ankam S, Farhy C, Fiengo L, Basa RCB, Gordon KL, Martin CT, Terskikh AV, Jordan-Sciutto KL, Price JH, McDonough PM
J Pharmacol Toxicol Methods 2022 Mar-Apr ;114:107157
Pinto A, Terskikh AV
Plast Reconstr Surg 2021 Dec 1 ;148(6S):39S-46S
The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment.
Riva L, Goellner S, Biering SB, Huang CT, Rubanov AN, Haselmann U, Warnes CM, De Jesus PD, Martin-Sancho L, Terskikh AV, Harris E, Pinkerton AB, Bartenschlager R, Chanda SK
J Virol 2021 Oct 27 ;95(22):e0099621
Farhy C, Hariharan S, Ylanko J, Orozco L, Zeng FY, Pass I, Ugarte F, Forsberg EC, Huang CT, Andrews DW, Terskikh AV
Elife 2019 Oct 22 ;8