Andrey Bobkov's Research Focus
Dr. Andrey Bobkov scientific interests include
- Applications of biophysical methods to characterize protein structural and functional properties in vitro. In particular, protein folding and stability, self- and hetero- association, and mechanisms of protein interaction with ligands, small molecules and inhibitors.
- Protein synthesis, folding and post translational processing in prokaryotic and eukaryotic cells.
- Implementation and development of protein purification and fractionation methods.
Andrey Bobkov's Bio
Andrey A. Bobkov, Director, Protein Production and Analysis, leads the Prebys Center effort on recombinant protein production and biophysical characterization. He has received an M.S. in Biochemistry from Moscow State University (Russia) and a Ph.D. in Biochemistry from the Bach Institute of Biochemistry of Russian Academy of Sciences. Andrey did his postdoctoral training at UCLA Chemistry and Biochemistry Department. Andrey has more than 20 years of experience and over 40 publications in the field of Biophysical Analysis. He teaches the Protein Analysis and Biophysics portion of the Structural Biology in Cell Signaling and Drug Discovery Course to SBP graduate students.
Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM
J Mol Biol 2015 Jul 3 ;427(13):2262-70
Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI
Medchemcomm 2013 Feb 1 ;4(2):332-339
Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI
Proc Natl Acad Sci U S A 2012 May 29 ;109(22):8576-81
Ryzhov P, Tian Y, Yao Y, Bobkov AA, Im W, Marassi FM
Biophys J 2020 Oct 6 ;119(7):1324-1334
Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution.
Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T
Biochim Biophys Acta Proteins Proteom 2020 Dec ;1868(12):140526
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD
Biochem J 2020 Aug 28 ;477(16):2999-3018
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
Chambers JM, Miller W, Quichocho G, Upadhye V, Matteo DA, Bobkov AA, Sohl CD, Schiffer JM
Biochemistry 2020 Feb 4 ;59(4):479-490
Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komives EA, Hogan PG
Nat Commun 2018 Oct 31 ;9(1):4536
Wei Y, Toth JI, Blanco GA, Bobkov AA, Petroski MD
J Biol Chem 2018 Dec 28 ;293(52):20169-20180