Andrey Bobkov, Ph.D.

Andrey Bobkov, headshot

Andrey Bobkov, Ph.D.

Director, Protein Production and Analysis

Andrey Bobkov's Research Focus

Cell Biology, Analytical Biophysics, Protein Chemistry
Protein Structure-Function Relationships
General Cell Biology
Bacteria, Cultured Cell Lines, Human Cell Lines, Insect Cell Lines
Biochemistry

Dr. Andrey Bobkov scientific interests include

  • Applications of biophysical methods to characterize protein structural and functional properties in vitro. In particular, protein folding and stability, self- and hetero- association, and mechanisms of protein interaction with ligands, small molecules and inhibitors.
  • Protein synthesis, folding and post translational processing in prokaryotic and eukaryotic cells.
  • Implementation and development of protein purification and fractionation methods.

Andrey Bobkov's Bio

Andrey A. Bobkov, Director, Protein Production and Analysis, leads the Prebys Center effort on recombinant protein production and biophysical characterization. He has received an M.S. in Biochemistry from Moscow State University (Russia) and a Ph.D. in Biochemistry from the Bach Institute of Biochemistry of Russian Academy of Sciences. Andrey did his postdoctoral training at  UCLA Chemistry and Biochemistry Department. Andrey has more than 20 years of experience and over 40 publications in the field of Biophysical Analysis. He teaches the Protein Analysis and Biophysics portion of the Structural Biology in Cell Signaling and Drug Discovery Course to SBP graduate students.


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Publications

Conformation of BCL-XL upon Membrane Integration.

Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM

J Mol Biol 2015 Jul 3 ;427(13):2262-70

Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.

Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI

Medchemcomm 2013 Feb 1 ;4(2):332-339

αE-catenin is an autoinhibited molecule that coactivates vinculin.

Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI

Proc Natl Acad Sci U S A 2012 May 29 ;109(22):8576-81

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Conformational States of the Cytoprotective Protein Bcl-xL.

Ryzhov P, Tian Y, Yao Y, Bobkov AA, Im W, Marassi FM

Biophys J 2020 Oct 6 ;119(7):1324-1334

Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution.

Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T

Biochim Biophys Acta Proteins Proteom 2020 Dec ;1868(12):140526

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD

Biochem J 2020 Aug 28 ;477(16):2999-3018

Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.

Chambers JM, Miller W, Quichocho G, Upadhye V, Matteo DA, Bobkov AA, Sohl CD, Schiffer JM

Biochemistry 2020 Feb 4 ;59(4):479-490

Calcium sensing by the STIM1 ER-luminal domain.

Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komives EA, Hogan PG

Nat Commun 2018 Oct 31 ;9(1):4536

Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors.

Wei Y, Toth JI, Blanco GA, Bobkov AA, Petroski MD

J Biol Chem 2018 Dec 28 ;293(52):20169-20180

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