Anne Bang, Ph.D.

Anne Bang's Research Focus

Cell Biology, Embryonic/Pluripotent Stem Cells, Neurogenesis, Neurodegeneration, Development and Differentiation, Development of Neuronal Circuits, Neurogenesis, Synaptic Transmission, Synapse Function, Synapse Formation and Maturation, Neuron-Glia Interactions in Myelin, Neurobiology, Neurodegeneration, Neurotransmitters
Molecular Genetics, High Content Imaging, Fluorescence Microscopy, Electrophysiology, Cellular and Molecular Imaging, Drug Discovery, In vivo Modeling, Microarrays
Neurodegenerative and Neuromuscular Diseases, Alzheimer's Disease, Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease), Congenital Disorders of Glycosylation, Glycosylation-Related Disorders, Multiple Sclerosis, Muscular Dystrophy, Aging-Related Diseases
Human Embryonic Stem Cells, Human Cell Lines, Human Adult/Somatic Stem Cells

Dr. Anne Bang is an experienced cell biologist and stem cell expert who leads efforts at the Prebys Center to develop patient cell specific and human induced pluripotent stem cell (hiPSC)-based disease models for drug screening and target identification. Her research program is primarily focused on neurological and neuromuscular disease, with the aim of designing human cell based models and assays that reflect higher order cellular functions and recapitulate disease phenotypes, yet have the throughput and reproducibility required for drug discovery. Towards this goal her group has worked to develop a suite of foundational high throughput assays to monitor neuronal morphology, mitochondrial function, and electrophysiology, using high content screening, and multi-electrode array formats. They have conducted high-throughput drug screens on muscular dystrophy patient cells, hiPSC-derived cardiomyocytes, and hiPSC-derived neurons, including from Alzheimer's patient specific hiPSC. Anne is a principal investigator for the National Institute of Mental Health (NIMH) National Cooperative Reprogrammed Cell Research Groups consortium, and also receives research support from rare disease foundations and pharma sponsored collaborations.

Anne Bang's Research Report

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Anne Bang's Bio

Dr. Anne Bang is an experienced cell biologist and stem cell expert who leads efforts at the Prebys Center to develop patient cell specific and human induced pluripotent stem cell (hiPSC)-based disease models for drug screening and target identification. Dr. Bang has over 20 years of experience in the fields of developmental and stem cell biology. She obtained a B.S. degree from Stanford University, a Ph.D. in Biological Sciences from the University of California, San Diego, and did postdoctoral training in the Neurobiology Laboratory at the Salk Institute for Biological Sciences where her studies focused on nervous system development. 

Anne's experience in stem cell biology began in 2005 when she joined ViaCyte, Inc. where she served as Director of Stem Cell Research and managed an interdisciplinary group working to develop human embryonic stem cells as a replenishable source of pancreatic cells for the treatment of diabetes. Her efforts focused on optimization of the differentiation process, and then on advancing the cell therapy product into development, scaled manufacturing, product characterization, and safety assessment. Anne is a co-inventor on multiple ViaCyte patents, and her team's contributions played a key role in securing a $20 MM California Institute of Regenerative Medicine (CIRM) Award. 

In June of 2010, Sanford Burnham Prebys recruited Anne as Director of Cell Biology to lead efforts in stem cell-based disease modeling at the Conrad Prebys Center for Chemical Genomics. Her role includes leading internal research projects, as well as external collaborations with academic and industry partners.  Anne's research program is primarily focused on neurological and neuromuscular disease, with the aim of designing human cell-based models and assays that recapitulate disease phenotypes, yet have the throughput and reproducibility required for drug discovery. Towards this goal her group has worked to develop a suite of foundational high throughput assays to monitor neuronal morphology, mitochondrial function, and electrophysiology, using high content screening, and multi-electrode array formats. They have conducted high-throughput drug screens on muscular dystrophy patient cells, hiPSC-derived cardiomyocytes, and hiPSC-derived neurons, including from Alzheimer's patient specific hiPSC. Anne is a principal investigator for the National Institute of Mental Health (NIMH) National Cooperative Reprogrammed Cell Research Groups consortium and has also received research support from rare disease foundations and pharma sponsored collaborations. She also serves on advisory boards for multiple biotechnology companies.


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Publications

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.

Kelly OG, Chan MY, Martinson LA, Kadoya K, Ostertag TM, Ross KG, Richardson M, Carpenter MK, D'Amour KA, Kroon E, Moorman M, Baetge EE, Bang AG

Nat Biotechnol 2011 Jul 31 ;29(8):750-6

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.

Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH

Proc Natl Acad Sci U S A 2015 May 19 ;112(20):E2725-34

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Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.

Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V

Front Pharmacol 2023 ;14:1190402

Assaying Chemical Long-Term Potentiation in Human iPSC-Derived Neuronal Networks.

Pré D, Wooten AT, Zhou H, Neil A, Bang AG

Methods Mol Biol 2023 ;2683:275-289

Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks.

Pré D, Wooten AT, Biesmans S, Hinckley S, Zhou H, Sherman SP, Kakad P, Gearhart J, Bang AG

Stem Cell Reports 2022 Sep 13 ;17(9):2141-2155

Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.

Liu R, Lee J, Tchoe Y, Pre D, Bourhis AM, D'Antonio-Chronowska A, Robin G, Lee SH, Ro YG, Vatsyayan R, Tonsfeldt KJ, Hossain LA, Phipps ML, Yoo J, Nogan J, Martinez JS, Frazer KA, Bang AG, Dayeh SA

Adv Funct Mater 2022 Feb 16 ;32(8)

iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.

Guo D, Daman K, Chen JJ, Shi MJ, Yan J, Matijasevic Z, Rickard AM, Bennett MH, Kiselyov A, Zhou H, Bang AG, Wagner KR, Maehr R, King OD, Hayward LJ, Emerson CP Jr

Elife 2022 Jan 25 ;11

Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies.

Ortiz-Cordero C, Bincoletto C, Dhoke NR, Selvaraj S, Magli A, Zhou H, Kim DH, Bang AG, Perlingeiro RCR

Stem Cell Reports 2021 Nov 9 ;16(11):2752-2767

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