Darren "Ben" Finlay, Ph.D.
Darren "Ben" Finlay's Research Focus
Dr. Finlay's research is focused on apoptosis (programmed cell death) and how this process can be manipulated to kill cancer cells.
Darren "Ben" Finlay's Bio
Education
University College Dublin
B.Sc. and Ph.D., Pharmacology, cell and molecular biology, signal transduction and cancer, First Class Honors
Publications
Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.
Finlay D, Richardson RD, Landberg LK, Howes AL, Vuori K
PLoS One 2010 Oct 12 ;5(10):e13375
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.
Cipres A, O'Malley DP, Li K, Finlay D, Baran PS, Vuori K
ACS Chem Biol 2010 Feb 19 ;5(2):195-202
Caspase-8 as a potential mediator of pro-tumorigenic signals.
Finlay D, Howes A, Vuori K
Cell Cycle 2009 Nov 1 ;8(21):3441-2
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids.
Davis JL, Kennedy C, Clerkin S, Treacy NJ, Dodd T, Moss C, Murphy A, Brazil DP, Cagney G, Brougham DF, Murad R, Finlay D, Vuori K, Crean J
Commun Biol 2022 Nov 27 ;5(1):1301
11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27(Kip1).
Nguyen BD, Stevens BL, Elson DJ, Finlay D, Gamble JT, Kopparapu PR, Tanguay RL, Buermeyer AB, Kerkvliet NI, Kolluri SK
FEBS J 2023 Apr ;290(8):2064-2084
Detection of TP53 Mutation in Acute Myeloid Leukemia by RT-PCR-Based Sanger Sequencing.
Novak ER, Deshpande A, Finlay D, Mason JR, Deshpande AJ, Adams PD, Li S
Methods Mol Biol 2023 ;2594:87-95
SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK.
Zhao M, Finlay D, Liddington R, Vuori K
Autophagy Rep 2022 ;1(1):38-41
Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
Raveendra-Panickar D, Finlay D, Layng FI, Lambert LJ, Celeridad M, Zhao M, Barbosa K, De Backer LJS, Kwong E, Gosalia P, Rodiles S, Holleran J, Ardecky R, Grotegut S, Olson S, Hutchinson JH, Pasquale EB, Vuori K, Deshpande AJ, Cosford NDP, Tautz L
J Biol Chem 2022 Jan ;298(1):101477
Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK.
Zhao M, Finlay D, Kwong E, Liddington R, Viollet B, Sasaoka N, Vuori K
Cell Signal 2022 Jan ;89:110170
