Jerold Chun, M.D., Ph.D.

Jerold Chun profile photo

Jerold Chun, M.D., Ph.D.

Senior Vice President, Neuroscience Drug Discovery


Research Assistant Professor(s)
Lab Website

Jerold Chun's Research Focus

Alzheimer's Disease, Hydrocephalus, Multiple Sclerosis
Aneuploidy, Development of Neuronal Circuits, Development and Differentiation, G-Protein Coupled Receptors, Mosaicism, Lipids, LPA, S1P, Single cell, Genome
Brain, Nervous System
  1. Genomic Mosaicism in the Brain: Genomic mosaicism (GM) is a surprising phenomenon whereby cells from the same brain actually have distinct genomes (different DNA sequences). We continue to define forms of GM, involved cell types, and GM’s impact on normal brain function and disease. Diseases of particular interest include Alzheimer’s disease, Down syndrome, Parkinson’s, and other neurodegenerative diseases as well as neuropsychiatric disorders and substance abuse.
  2. Lysophospholipid Receptor Signaling: Lysophospholipids, such as lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are small fat molecules that act through G protein-coupled receptors (GPCRs) on the surface of cells. We continue to study fundamental aspects of their signaling properties, and their disease roles in hydrocephalus (water on the brain), neuropsychiatric disorders (schizophrenia, autism), and neurodegenerative disorders (multiple sclerosis, Alzheimer’s disease).
  3. Neuroscience Drug Discovery: From these and other research areas, new therapeutics for diseases of the brain are being pursued, which include identifying new targets, novel biomarkers, and mechanism-of-action studies. This approach successfully aided in the development of the first oral treatment for multiple sclerosis, fingolimod, and related lysophospholipid receptor compounds. Drug discovery efforts include not only small molecules, but also other forms of molecular therapeutics.

Jerold Chun's Bio

Professor at UCSD and TSRI

Department Head, Molecular Neuroscience, Merck Research Labs

Why do you do what you do?

I love doing science, and a chance to do some good for the world. Sanford Burnham Prebys is a great place to pursue science.
 

Education

1988-1991: Postdoctoral Fellow, Whitehead Institute/MIT, laboratories of Drs. Rudolf Jaenisch and David Baltimore, Developmental and Molecular Biology
1988: M.D., Ph.D., Stanford University School of Medicine, Neuroscience
1981: B.A., University of Hawaii at Manoa, English and Biology
 

Honors and recognition

2016: Alzheimer’s San Diego Courage and Hope Award
2014: Thomson Reuters World’s Most Influential Scientific Minds list of highly cited researchers 
2011: Killam Lecturer, Montreal Neurological Institute 
2010: Journal of Lipid Research Lecturer, Keystone Symposium on Bioactive Lipids: Biochemistry and Diseases, Kyoto, Japan 
2007: Chancellor’s Award for Excellence in Neuroscience, LSU Medical School 
1999-2006: Independent Scientist Award, NIMH 
1994-1999: First Award, NIMH 
1993-1995: Basil O'Connor Scholar (March of Dimes Birth Defects Foundation), UCSD 
1992-1995: Klingenstein Fellow in the Neurosciences, UCSD 
1992-1994: Alfred P. Sloan Research Fellow, UCSD 
1988-1991: Helen Hay Whitney Fellow, Whitehead Institute for Biomedical Research 
1981-1988: Trainee, Medical Scientist Training Program (MSTP), Stanford University School of Medicine 


pipetting

Publications

Somatic APP gene recombination in Alzheimer's disease and normal neurons.

Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J

Nature 2018 Nov ;563(7733):639-645

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Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke.

Nitzsche A, Poittevin M, Benarab A, Bonnin P, Faraco G, Uchida H, Favre J, Garcia-Bonilla L, Garcia MC, Leger PP, Therond P, Mathivet T, Autret G, Baudrie V, Couty L, Kono M, Chevallier A, Niazi H, Tharaux PL, Chun J, Schwab SR, Eichmann A, Tavitian B, Proia RL, Charriaut-Marlangue C, Sanchez T, Kubis N, Henrion D, Iadecola C, Hla T, Camerer E

Circ Res 2020 Dec 2 ;

Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.

Rosell-Valle C, Pedraza C, Manuel I, Moreno-Rodríguez M, Rodríguez-Puertas R, Castilla-Ortega E, Caramés JM, Gómez Conde AI, Zambrana-Infantes E, Ortega-Pinazo J, Serrano-Castro PJ, Chun J, Rodríguez De Fonseca F, Santín LJ, Estivill-Torrús G

Prog Neuropsychopharmacol Biol Psychiatry 2020 Nov 2 ;:110156

LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.

Wang F, Liu S, Pei J, Cai L, Liu N, Liang T, Dong X, Cong X, Chun J, Chen J, Hu S, Chen X

Theranostics 2020 ;10(24):10892-10907

Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.

Fransson J, Gómez-Conde AI, Romero-Imbroda J, Fernández O, Leyva L, de Fonseca FR, Chun J, Louapre C, Van-Evercooren AB, Zujovic V, Estivill-Torrús G, García-Díaz B

Mol Neurobiol 2020 Sep 24 ;

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