Jerold Chun, M.D., Ph.D.
Research Assistant Professor(s)
Lab Website
Jerold Chun's Research Focus
- Genomic Mosaicism in the Brain: Genomic mosaicism (GM) is a surprising phenomenon whereby cells from the same brain actually have distinct genomes (different DNA sequences). We continue to define forms of GM, involved cell types, and GM’s impact on normal brain function and disease. Diseases of particular interest include Alzheimer’s disease, Down syndrome, Parkinson’s, and other neurodegenerative diseases as well as neuropsychiatric disorders and substance abuse.
- Lysophospholipid Receptor Signaling: Lysophospholipids, such as lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are small fat molecules that act through G protein-coupled receptors (GPCRs) on the surface of cells. We continue to study fundamental aspects of their signaling properties, and their disease roles in hydrocephalus (water on the brain), neuropsychiatric disorders (schizophrenia, autism), and neurodegenerative disorders (multiple sclerosis, Alzheimer’s disease).
- Neuroscience Drug Discovery: From these and other research areas, new therapeutics for diseases of the brain are being pursued, which include identifying new targets, novel biomarkers, and mechanism-of-action studies. This approach successfully aided in the development of the first oral treatment for multiple sclerosis, fingolimod, and related lysophospholipid receptor compounds. Drug discovery efforts include not only small molecules, but also other forms of molecular therapeutics.
Jerold Chun's Bio
Professor at UC San Diego and TSRI
Department Head, Molecular Neuroscience, Merck Research Labs
Why do you do what you do?
I love doing science, and a chance to do some good for the world. Sanford Burnham Prebys is a great place to pursue science.
Education
1988-1991: Postdoctoral Fellow, Whitehead Institute/MIT, laboratories of Drs. Rudolf Jaenisch and David Baltimore, Developmental and Molecular Biology
1988: M.D., Ph.D., Stanford University School of Medicine, Neuroscience
1981: B.A., University of Hawaii at Manoa, English and Biology
Honors and recognition
2016: Alzheimer’s San Diego Courage and Hope Award
2014: Thomson Reuters World’s Most Influential Scientific Minds list of highly cited researchers
2011: Killam Lecturer, Montreal Neurological Institute
2010: Journal of Lipid Research Lecturer, Keystone Symposium on Bioactive Lipids: Biochemistry and Diseases, Kyoto, Japan
2007: Chancellor’s Award for Excellence in Neuroscience, LSU Medical School
1999-2006: Independent Scientist Award, NIMH
1994-1999: First Award, NIMH
1993-1995: Basil O'Connor Scholar (March of Dimes Birth Defects Foundation), UCSD
1992-1995: Klingenstein Fellow in the Neurosciences, UCSD
1992-1994: Alfred P. Sloan Research Fellow, UCSD
1988-1991: Helen Hay Whitney Fellow, Whitehead Institute for Biomedical Research
1981-1988: Trainee, Medical Scientist Training Program (MSTP), Stanford University School of Medicine
Publications
Somatic APP gene recombination in Alzheimer's disease and normal neurons.
Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J
Nature 2018 Nov ;563(7733):639-645
A Functionally Defined In Vivo Astrocyte Population Identified by c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate-Early Astrocytes (ieAstrocytes).
Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J
eNeuro 2018 Sep-Oct ;5(5)
A Functionally Defined In Vivo Astrocyte Population Identified by c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate-Early Astrocytes (ieAstrocytes).
Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J
eNeuro 2018 Sep-Oct ;5(5)
Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic.
Chun J
Med (N Y) 2022 Oct 14 ;3(10):648-650
CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries.
Abi-Ghanem C, Jonnalagadda D, Chun J, Kihara Y, Ranscht B
Front Cell Neurosci 2022 ;16:908401
Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice.
Khiar-Fernández N, Zian D, Vázquez-Villa H, Martínez RF, Escobar-Peña A, Foronda-Sainz R, Ray M, Puigdomenech-Poch M, Cincilla G, Sánchez-Martínez M, Kihara Y, Chun J, López-Vales R, López-Rodríguez ML, Ortega-Gutiérrez S
J Med Chem 2022 Aug 25 ;65(16):10956-10974
LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction.
Pei J, Cai L, Wang F, Xu C, Pei S, Guo H, Sun X, Chun J, Cong X, Zhu W, Zheng Z, Chen X
Circ Res 2022 Aug 19 ;131(5):388-403
Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod.
Kihara Y, Zhu Y, Jonnalagadda D, Romanow W, Palmer C, Siddoway B, Rivera R, Dutta R, Trapp BD, Chun J
Front Cell Neurosci 2022 ;16:918041
The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis.
Cohan SL, Benedict RHB, Cree BAC, DeLuca J, Hua LH, Chun J
CNS Drugs 2022 Jul ;36(7):703-719