John Šedý, Ph.D.

John Šedý's Research Focus

Cancer, Immune Disorders, Leukemia/Lymphoma, Inflammatory/Autoimmune Disease, Multiple Sclerosis, Psoriasis, Skin Cancer and Melanoma, Systemic Lupus Erythematosus
Adaptive Immunity, Cell Signaling, Cytokines, Host-Pathogen Interactions, Inflammation, Innate Immunity, Signal Transduction, TNF-Family, Tumor Microenvironment
Immune System and Inflammation, Hematopoietic System
Human, Human Cell Lines, Mouse Cell Lines, Primary Human Cells

Faculty Mentor: Carl F. Ware, Ph.D.

John Šedý's Bio

Education

  • Ph.D. Washington University in Saint Louis, Immunology, 2005
  • B.S. University of Illinois in Urbana-Champaign, Physics, 1995
  • B.S. University of Illinois in Urbana-Champaign, Biophysics, 1995

general accessory

Publications

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells.

Bekiaris V, Šedý JR, Ware CF

Front Immunol 2014 ;5:654

Structural determinants of herpesvirus entry mediator recognition by murine B and T lymphocyte attenuator.

Nelson CA, Fremont MD, Sedy JR, Norris PS, Ware CF, Murphy KM, Fremont DH

J Immunol 2008 Jan 15 ;180(2):940-7

HVEM network signaling in cancer.

Šedý JR, Ramezani-Rad P

Adv Cancer Res 2019 ;142:145-186

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Contactin-1 Is Required for Peripheral Innervation and Immune Homeostasis Within the Intestinal Mucosa.

Veny M, Grases D, Kucharova K, Lin WW, Nguyen J, Huang S, Ware CF, Ranscht B, Šedý JR

Front Immunol 2020 ;11:1268

HVEM network signaling in cancer.

Šedý JR, Ramezani-Rad P

Adv Cancer Res 2019 ;142:145-186

A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator.

Šedý JR, Balmert MO, Ware BC, Smith W, Nemčovičova I, Norris PS, Miller BR, Aivazian D, Ware CF

J Biol Chem 2017 Dec 22 ;292(51):21060-21070

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.

Ward-Kavanagh LK, Lin WW, Šedý JR, Ware CF

Immunity 2016 May 17 ;44(5):1005-19

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells.

Bekiaris V, Šedý JR, Ware CF

Front Immunol 2014 ;5:654

The inhibitory receptor BTLA controls γδ T cell homeostasis and inflammatory responses.

Bekiaris V, Šedý JR, Macauley MG, Rhode-Kurnow A, Ware CF

Immunity 2013 Dec 12 ;39(6):1082-1094

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