Karen Ocorr's Research Focus
The Ocorr Lab is investigating the cellular and molecular basis of adult heart function and cardiomyopathies using the genetic model system Drosophila.
We use functional, electrophysiological, biochemical and immunohistochemical techniques that allow us to examine the roles of genes and gene products in cardiac channelopathies and stress-related cardiomyopathies.
Our lab pioneered the development of a novel methodology (Semi-automatic Optical Heartbeat Analysis, SOHA) that permits the quantification of heartbeat parameters in model systems with small hearts.
Using this system we have identified several ion channels in the fly heart that play prominent roles in repolarization of the human heart and cause arrhythmia in both the fly and in humans when mutated. We also have developed a number of other disease models including a diabetic-like cardiomyopathy induced by high sugar diet and hypoxia-induced cardiomyopathy.
Recently we have begun collaborations with NASA (by winning a Space Florida International Space Station Research Competition). We are using the fly to uncover the molecular/cellular basis for cardiac and muscle atrophy in astronauts exposed to extended periods of microgravity despite extensive exercise regimes aboard the ISS. Our flies were launched aboard SpaceX 3 for a month-long exposure to micro-gravity.
Karen Ocorr's Bio
B.A., Lehigh University, Bethlehem, PA, Biology
Ph.D., Wesleyan University, Middletown, CT, Neuroscience NIMH
Postdoctoral Fellow, University of Texas Medical School, Houston, TX, Neuroscience NIMH
Postdoctoral Fellow, Stanford University, Palo Alto, CA, Neurochemistry
Prestigious funding awards or major collaborative grants
2015 - 2020 NIH R01 HL132241-01A1: Using Drosophila genetics to identify molecular links between ion channel dysfunction and pathological cardiac remodeling.
(PI) 2013-2018 NASA NRA #NNH12ZTT001N: The effects of microgravity on cardiac function, structure and gene expression using the Drosophila model. (Co-I)
Honor and awards
2014: Space Florida International Space Station Research Competition Winner – Co-investigator - One of three Basic Research proposals selected for launch aboard SpaceX3 - Mission completed, live flies returned on May 18,2014
2001: Excellence in Teaching Award, University of Michigan
1997: Excellence in Teaching Award, University of Michigan
1986-1988: National Institute of Mental Health Fellowship
1983-1985: National Institute of Mental Health Fellowship
1981: Sigma Xi Research Award 1980 MBL Scholarship, Neural Systems and Behavior Course
1971-1975: National Merit Scholarship, Lehigh University
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.
Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R
Proc Natl Acad Sci U S A 2007 Mar 6 ;104(10):3943-8
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.
Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W, Bodmer R, Ocorr K
Biotechniques 2009 Feb ;46(2):101-13
Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.
Ocorr K, Zambon A, Nudell Y, Pineda S, Diop S, Tang M, Akasaka T, Taylor E
PLoS Genet 2017 May ;13(5):e1006786
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila.
Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K
Cell Rep 2020 Dec 8 ;33(10):108445
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.
Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R
Elife 2020 Oct 2 ;9
Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology.
Walls SM, Chatfield DA, Ocorr K, Harris GL, Bodmer R
Dis Model Mech 2020 Aug 14 ;13(8)
Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease.
Akasaka T, Ocorr K, Lin L, Vogler G, Bodmer R, Grossfeld P
J Cardiovasc Dev Dis 2020 Jun 2 ;7(2)
Elmén L, Volpato CB, Kervadec A, Pineda S, Kalvakuri S, Alayari NN, Foco L, Pramstaller PP, Ocorr K, Rossini A, Cammarato A, Colas AR, Hicks AA, Bodmer R
Dis Model Mech 2020 Jul 20 ;13(7)
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Chang K, Kang P, Liu Y, Huang K, Miao T, Sagona AP, Nezis IP, Bodmer R, Ocorr K, Bai H
Autophagy 2020 Oct ;16(10):1807-1822