Kristiina Vuori, M.D., Ph.D.
Research Assistant Professor(s)
Kristiina Vuori's Research Focus
Dr. Vuori's research is aimed at unraveling the cell mechanisms of the most life-threatening aspect of cancer, which is cancer metastasis. Metastasis is responsible for nearly all deaths in cancer patients, and understanding of the mechanisms that turn a cancer from a locally growing tumor into highly metastatic cancer cells will provide clues how to prevent this step in cancer progression. All cells in our body stick to one another and to the packaging material, or extracellular matrix, around them. This adhesion is essential for cell survival; if cells become detached from their microenvironment, they will die through a process known as apoptosis. This phenomenon, which is called adhesion dependency of survival, is one of the safeguards that maintain the integrity and normal function of tissues, and prevent cells from becoming cancerous. Normal cells cannot detach from their tissue and establish themselves somewhere else, because they will die on the way. Yet cancer cells somehow get around this requirement; they trespass aggressively into other tissues and metastasize to distant sites in the body without dying. Dr. Vuori’s work is aimed at identifying the molecular mechanisms that in normal cells makes them adhesion-dependent; false action of the very same mechanisms is likely to be the key step in allowing cancer cells to metastasize.
Kristiina Vuori's Bio
Kristiina Vuori earned her M.D. and Ph.D. at University of Oulu, Finland. After completion of internship and residency, she received postdoctoral training at the Institute and was appointed to faculty in 1996. Dr. Vuori was selected as a PEW Scholar in the Biomedical Sciences in 1997. She has been co-Director of the Conrad Prebys Center for Chemical Genomics, housed at Sanford Burnham Prebys, since its inception in 2005. She was appointed Deputy Director of the Institute's NCI-Designated Cancer Center in 2003, and Director of the Cancer Center in 2006. In 2008, she was appointed Executive Vice President for Scientific Affairs at Sanford Burnham Prebys. She was President of the Institute from 2010 to 2022.
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.
Cipres A, O'Malley DP, Li K, Finlay D, Baran PS, Vuori K
ACS Chem Biol 2010 Feb 19 ;5(2):195-202
Critical role for caspase-8 in epidermal growth factor signaling.
Finlay D, Howes A, Vuori K
Cancer Res 2009 Jun 15 ;69(12):5023-9
Cell biology. Two lipids that give direction.
Côté JF, Vuori K
Science 2009 Apr 17 ;324(5925):346-7
The effect of puppyhood and adolescent diet on the incidence of chronic enteropathy in dogs later in life.
Vuori KA, Hemida M, Moore R, Salin S, Rosendahl S, Anturaniemi J, Hielm-Björkman A
Sci Rep 2023 Feb 9 ;13(1):1830
Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study.
Rosendahl S, Anturaniemi J, Kukko-Lukjanov TK, Vuori KA, Moore R, Hemida M, Muhle A, Hielm-Björkman A
Front Vet Sci 2022 ;9:1066851
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids.
Davis JL, Kennedy C, Clerkin S, Treacy NJ, Dodd T, Moss C, Murphy A, Brazil DP, Cagney G, Brougham DF, Murad R, Finlay D, Vuori K, Crean J
Commun Biol 2022 Nov 27 ;5(1):1301
Response to letter regarding "Puppyhood diet as a factor in the development of owner-reported allergy/atopy skin signs in adult dogs in Finland".
Hemida MBM, Vuori KA, Moore R, Anturaniemi J, Rosendahl S, Barrouin-Melo SM, Hielm-Björkman A
J Vet Intern Med 2022 Sep ;36(5):1564-1565
SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK.
Zhao M, Finlay D, Liddington R, Vuori K
Autophagy Rep 2022 ;1(1):38-41
Copepod reproductive effort and oxidative status as responses to warming in the marine environment.
von Weissenberg E, Jansson A, Vuori KA, Engström-Öst J
Ecol Evol 2022 Feb ;12(2):e8594