Massimo Bottini, Ph.D.
Lab Website
Massimo Bottini's Research Focus
A novel nanotechnology approach for osteoarthritis
Dr. Bottini’s goal is to fabricate efficient and biocompatible nanoparticles to deliver cargo into osteoarthritic chondrocytes and reestablish cartilage homeostasis. His laboratory discovered that graphitic nanoparticles are able to deliver cargo into osteoarthritic chondrocytes in vivo and is optimizing the cargo delivery efficiency and biocompatibility of nanoparticles in the joints of arthritic mice.
Massimo Bottini's Bio
Dr. Bottini earned his Ph.D. in Sensorial and Learning Systems at the University of Rome Tor Vergata, Rome, Italy in 2004.
Publications
Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.
Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M
ACS Nano 2014 Dec 23 ;8(12):12280-91
Dual role of the Trps1 transcription factor in dentin mineralization.
Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D
J Biol Chem 2014 Oct 3 ;289(40):27481-93
In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes.
Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M
Bioconjug Chem 2013 Jun 19 ;24(6):852-8
Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells.
Bolean M, Izzi B, van Kerckhoven S, Bottini M, Ramos AP, Millán JL, Hoylaerts MF, Ciancaglini P
Biochim Biophys Acta Gen Subj 2020 Aug ;1864(8):129629
Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo.
Amadeu de Oliveira F, Narisawa S, Bottini M, Millán JL
J Bone Miner Res 2020 Apr 28 ;
Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization.
Veschi EA, Bolean M, Strzelecka-Kiliszek A, Bandorowicz-Pikula J, Pikula S, Granjon T, Mebarek S, Magne D, Ramos AP, Rosato N, Millán JL, Buchet R, Bottini M, Ciancaglini P
Int J Mol Sci 2020 Feb 18 ;21(4)
Cholesterol Regulates the Incorporation and Catalytic Activity of Tissue-Nonspecific Alkaline Phosphatase in DPPC Monolayers.
Derradi R, Bolean M, Simão AMS, Caseli L, Millán JL, Bottini M, Ciancaglini P, Ramos AP
Langmuir 2019 Nov 26 ;35(47):15232-15241
Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.
Plaut JS, Strzelecka-Kiliszek A, Bozycki L, Pikula S, Buchet R, Mebarek S, Chadli M, Bolean M, Simao AMS, Ciancaglini P, Magrini A, Rosato N, Magne D, Girard-Egrot A, Farquharson C, Esener SC, Millan JL, Bottini M
Arch Biochem Biophys 2019 May 30 ;667:14-21
Lipid microenvironment affects the ability of proteoliposomes harboring TNAP to induce mineralization without nucleators.
Simão AMS, Bolean M, Favarin BZ, Veschi EA, Tovani CB, Ramos AP, Bottini M, Buchet R, Millán JL, Ciancaglini P
J Bone Miner Metab 2019 Jul ;37(4):607-613