Massimo Bottini, Ph.D.

Massimo Bottini, Ph.D.

Affiliate Associate Professor

Fax: (858) 713-9925

Lab Website

Massimo Bottini's Research Focus


A novel nanotechnology approach for osteoarthritis 

Dr. Bottini’s goal is to fabricate efficient and biocompatible nanoparticles to deliver cargo into osteoarthritic chondrocytes and reestablish cartilage homeostasis. His laboratory discovered that graphitic nanoparticles are able to deliver cargo into osteoarthritic chondrocytes in vivo and is optimizing the cargo delivery efficiency and biocompatibility of nanoparticles in the joints of arthritic mice.

Massimo Bottini's Bio

Dr. Bottini earned his Ph.D. in Sensorial and Learning Systems at the University of Rome Tor Vergata, Rome, Italy in 2004.



Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M

ACS Nano 2014 Dec 23 ;8(12):12280-91

Dual role of the Trps1 transcription factor in dentin mineralization.

Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D

J Biol Chem 2014 Oct 3 ;289(40):27481-93

In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes.

Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M

Bioconjug Chem 2013 Jun 19 ;24(6):852-8

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Phosphatidylserine controls calcium phosphate nucleation and growth on lipid monolayers: A physicochemical understanding of matrix vesicle-driven biomineralization.

Cruz MAE, Ferreira CR, Tovani CB, de Oliveira FA, Bolean M, Caseli L, Mebarek S, Millán JL, Buchet R, Bottini M, Ciancaglini P, Paula Ramos A

J Struct Biol 2020 Nov 1 ;212(2):107607

Lipid composition modulates ATP hydrolysis and calcium phosphate mineral propagation by TNAP-harboring proteoliposomes.

Favarin BZ, Bolean M, Ramos AP, Magrini A, Rosato N, Millán JL, Bottini M, Costa-Filho AJ, Ciancaglini P

Arch Biochem Biophys 2020 Sep 30 ;691:108482

Characterization of the in Vitro Osteogenic Response to Submicron TiO2 Particles of Varying Structure and Crystallinity.

Tovani CB, Ferreira CR, Simão AMS, Bolean M, Coppeta L, Rosato N, Bottini M, Ciancaglini P, Ramos AP

ACS Omega 2020 Jul 14 ;5(27):16491-16501

Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells.

Bolean M, Izzi B, van Kerckhoven S, Bottini M, Ramos AP, Millán JL, Hoylaerts MF, Ciancaglini P

Biochim Biophys Acta Gen Subj 2020 Aug ;1864(8):129629

Visualization of Mineral-Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo.

Amadeu de Oliveira F, Narisawa S, Bottini M, Millán JL

J Bone Miner Res 2020 Sep ;35(9):1765-1771

Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization.

Veschi EA, Bolean M, Strzelecka-Kiliszek A, Bandorowicz-Pikula J, Pikula S, Granjon T, Mebarek S, Magne D, Ramos AP, Rosato N, Millán JL, Buchet R, Bottini M, Ciancaglini P

Int J Mol Sci 2020 Feb 18 ;21(4)

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