Massimo Bottini, Ph.D.
Lab Website
Massimo Bottini's Research Focus
A novel nanotechnology approach for osteoarthritis
Dr. Bottini’s goal is to fabricate efficient and biocompatible nanoparticles to deliver cargo into osteoarthritic chondrocytes and reestablish cartilage homeostasis. His laboratory discovered that graphitic nanoparticles are able to deliver cargo into osteoarthritic chondrocytes in vivo and is optimizing the cargo delivery efficiency and biocompatibility of nanoparticles in the joints of arthritic mice.
Massimo Bottini's Bio
Dr. Bottini earned his Ph.D. in Sensorial and Learning Systems at the University of Rome Tor Vergata, Rome, Italy in 2004.
Publications
Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.
Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M
ACS Nano 2014 Dec 23 ;8(12):12280-91
Dual role of the Trps1 transcription factor in dentin mineralization.
Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D
J Biol Chem 2014 Oct 3 ;289(40):27481-93
In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes.
Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M
Bioconjug Chem 2013 Jun 19 ;24(6):852-8
Cholesterol Regulates the Incorporation and Catalytic Activity of Tissue-Nonspecific Alkaline Phosphatase in DPPC Monolayers.
Derradi R, Bolean M, Simão AMS, Caseli L, Millán JL, Bottini M, Ciancaglini P, Ramos AP
Langmuir 2019 Nov 26 ;35(47):15232-15241
Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.
Plaut JS, Strzelecka-Kiliszek A, Bozycki L, Pikula S, Buchet R, Mebarek S, Chadli M, Bolean M, Simao AMS, Ciancaglini P, Magrini A, Rosato N, Magne D, Girard-Egrot A, Farquharson C, Esener SC, Millan JL, Bottini M
Arch Biochem Biophys 2019 May 30 ;667:14-21
Lipid microenvironment affects the ability of proteoliposomes harboring TNAP to induce mineralization without nucleators.
Simão AMS, Bolean M, Favarin BZ, Veschi EA, Tovani CB, Ramos AP, Bottini M, Buchet R, Millán JL, Ciancaglini P
J Bone Miner Metab 2019 Jul ;37(4):607-613
Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors.
Mukherjee SP, Bondarenko O, Kohonen P, Andón FT, Brzicová T, Gessner I, Mathur S, Bottini M, Calligari P, Stella L, Kisin E, Shvedova A, Autio R, Salminen-Mankonen H, Lahesmaa R, Fadeel B
Sci Rep 2018 Jan 18 ;8(1):1115
Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery.
Bhattacharya K, Sacchetti C, Costa PM, Sommertune J, Brandner BD, Magrini A, Rosato N, Bottini N, Bottini M, Fadeel B
Adv Healthc Mater 2018 Mar ;7(6):e1700916
Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.
Bottini M, Mebarek S, Anderson KL, Strzelecka-Kiliszek A, Bozycki L, Simão AMS, Bolean M, Ciancaglini P, Pikula JB, Pikula S, Magne D, Volkmann N, Hanein D, Millán JL, Buchet R
Biochim Biophys Acta Gen Subj 2018 Mar ;1862(3):532-546