Maximiliano D'Angelo, Ph.D.
Maximiliano D'Angelo's Research Focus
A hallmark of eukaryotic cells is that the genome is enclosed by the Nuclear Envelope (NE), a double lipid bilayer that physically separates the nuclear interior from the cytoplasm. The NE is penetrated by large multiprotein channels known Nuclear Pore Complexes or NPCs. Historically, NPCs were considered static structures whose main and only function was to control the exchange of molecules between the nucleus and the cytoplasm. But this simplistic view of the NPC is now changing, as it has become evident that NPCs are highly dynamic complexes with many transport-independent functions such as chromatin organization, gene expression regulation and the control of cell fate. The main focus of our laboratory is to study the role of nuclear pore complexes in nuclear organization, cell differentiation, aging and disease.
Maximiliano D'Angelo's Bio
Dr. D’Angelo earned his B.S. and M.S. degrees in chemistry at the University of Cordoba, Argentina, and his Ph.D. in biochemistry and molecular biology from University of Buenos Aires. He then trained as a postdoctoral fellow in cell biology at The Salk and the Scripps Research Institute in San Diego. In 2011, Dr. D’Angelo was appointed as an Assistant Professor of the Biochemistry and Biophysics department and a Principal Investigator of the Cardiovascular Research Institute at the University of California San Francisco. In 2012, he was named Scholar of the Pew Charitable Trust. Dr. D’Angelo was recruited the to the Development, Aging and Regenerative Program at Sanford Burnham Prebys in October 2014.
Funding awards and collaborative grants
Pew Charitable Trust Scholar in Biomedical Sciences
Publications
Nuclear pore complexes and regulation of gene expression.
Raices M, D'Angelo MA
Curr Opin Cell Biol 2017 Jun ;46:26-32
Linking Nucleoporins, Mitosis, and Colon Cancer.
Wong RW, D'Angelo M
Cell Chem Biol 2016 May 19 ;23(5):537-539
Nup62: a novel regulator of centrosome integrity and function.
Borlido J, D'Angelo MA
Cell Cycle 2014 ;13(1):14
Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome.
Raices M, D'Angelo MA
Cold Spring Harb Perspect Biol 2021 Jul 26 ;
Nuclear pore complexes in development and tissue homeostasis.
Guglielmi V, Sakuma S, D'Angelo MA
Development 2020 Dec 15 ;147(23)
Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death.
Sakuma S, Raices M, Borlido J, Guglielmi V, Zhu EYS, D'Angelo MA
Cancer Discov 2021 Jan ;11(1):176-193
Nuclear Pore Complexes Are Key Regulators of Oligodendrocyte Differentiation and Function.
Raices M, D'Angelo MA
Neuron 2019 May 8 ;102(3):509-511
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis.
Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley LM, D'Angelo MA
Nat Immunol 2018 Jun ;19(6):594-605
Nup62-mediated nuclear import of p63 in squamous cell carcinoma.
Borlido J, D'Angelo MA
EMBO Rep 2018 Jan ;19(1):3-4