Maximiliano D'Angelo, Ph.D.
Maximiliano D'Angelo's Research Focus
Nuclear pore complexes (NPCs) are multiprotein channels that penetrate the nuclear envelope and act as the gatekeepers of the genome. NPCs work together with nuclear transport receptors to ferry molecules in and out of the nucleus. They also regulate multiple cellular processes such as gene expression, chromatin organization, and RNA processing in a transport independent manner. In recent years, our lab and others identified that cells can change the configuration of nuclear pore complexes to modulate specific cellular processes, such as T cell homeostasis and activation, muscle differentiation, tumor development and metastasis.
Because of the essential function of nuclear pore complexes in cell survival, proliferation and differentiation, it is not surprising that changes in the nuclear transport machinery have long been observed in cancer cells. Yet, how most of these alterations contribute to cell transformation and tumor development is poorly understood.
Our laboratory is working to:
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Establish how alterations in the nuclear transport machinery contribute to cancer development and progression
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Dissect the role of nuclear pore complexes in the regulation of immune cell function
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Identify, validate, and modulate new therapeutic targets for cancer and immune disorders
Our long-term goal is to develop novel therapies targeting the cellular nuclear transport machinery.
Maximiliano D'Angelo's Bio
Dr. D’Angelo earned his B.S. and M.S. degrees in chemistry at the University of Cordoba, Argentina, and his Ph.D. in biochemistry and molecular biology from University of Buenos Aires. He then trained as a postdoctoral fellow in cell biology at The Salk and the Scripps Research Institute in San Diego. In 2011, Dr. D’Angelo was appointed as an Assistant Professor of the Biochemistry and Biophysics department and a Principal Investigator of the Cardiovascular Research Institute at the University of California San Francisco. In 2012, he was named Scholar of the Pew Charitable Trust. Dr. D’Angelo was recruited the to the Development, Aging and Regenerative Program at Sanford Burnham Prebys in October 2014.
Funding awards and collaborative grants
Pew Charitable Trust Scholar in Biomedical Sciences
Publications
Nuclear pore complexes and regulation of gene expression.
Raices M, D'Angelo MA
Curr Opin Cell Biol 2017 Jun ;46:26-32
Linking Nucleoporins, Mitosis, and Colon Cancer.
Wong RW, D'Angelo M
Cell Chem Biol 2016 May 19 ;23(5):537-539
Nup62: a novel regulator of centrosome integrity and function.
Borlido J, D'Angelo MA
Cell Cycle 2014 ;13(1):14
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity.
Sakuma S, Zhu EY, Raices M, Zhang P, Murad R, D'Angelo MA
Life Sci Alliance 2022 Mar ;5(3)
Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome.
Raices M, D'Angelo MA
Cold Spring Harb Perspect Biol 2021 Jul 26 ;
Nuclear pore complexes in development and tissue homeostasis.
Guglielmi V, Sakuma S, D'Angelo MA
Development 2020 Dec 15 ;147(23)
Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death.
Sakuma S, Raices M, Borlido J, Guglielmi V, Zhu EYS, D'Angelo MA
Cancer Discov 2021 Jan ;11(1):176-193
Nuclear Pore Complexes Are Key Regulators of Oligodendrocyte Differentiation and Function.
Raices M, D'Angelo MA
Neuron 2019 May 8 ;102(3):509-511
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis.
Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley LM, D'Angelo MA
Nat Immunol 2018 Jun ;19(6):594-605