Peter Teriete, Ph.D.

Peter Teriete's Research Focus

Brain, Pancreas, General Cell Biology
Fuel Metabolism, Metastasis, Oncogenes, Protein Structure-Function Relationships, Posttranslational Modification, Transcription Factors
Computational Modeling
Biochemistry, Molecular Biology, Structural Biology, Cancer, HIV/AIDS, Lung Cancer, Prostate Cancer, Pancreatic Cancer, Breast Cancer, Brain Cancer
Biophysics, Cell Biology, Chemical Biology, Cellular and Molecular Imaging, Chemical Genetics, Computational Modeling, Drug Discovery, Fragment-Based Drug Design, In Silico Protein-Protein Docking, Mass Spectrometry, Metabolomics, Microfluidic Technology, Protein Structure Prediction, Protein Synthesis, Protein-Protein Interactions, Protein-Small Molecule Interactions, Rational Drug Design, Small Molecule Compounds, X-Ray Crystallography, Nuclear Magnetic Resonance Spectroscopy (NMR)

I am utilizing my expertise in structural biochemistry and biophysics to advance novel therapies for a number of diseases. Gaining a detailed understanding of the molecular effects of small molecule modulators on their target, most of which are proteins, can help us to design more potent, efficient and selective drugs. By combining structural biochemistry and biophysics with chemical biology, we can effectively probe and answer important biological questions about the molecular drivers of many diseases.

Peter Teriete's Research Report

Utilizing structural biology approaches, such as NMR and X-ray crystallography, as well as broader biophysical methodologies, I am interested in elucidating the molecular signatures that govern function and therapeutic modulation of highly relevant disease targets. Currently I am investigating a novel mechanism to modulate c-Myc activity, a well established onocogen, in its biological context together with my colleagues Nicholas Cosford and Robert Wechsler-Reya here at SBP. Furthermore, we are advancing the design of new inhibitors to the Inhibitor of Apoptosis (IAP) family of proteins, which play an essential role in the progression of cancer, while elucidating more fundamental biological questions about the role of these proteins in the cancer cell signaling network. My work is strongly centered in the collaborative environment SBP provides and allows me to pursue exciting and important research in human biology and disease.

Peter Teriete's Bio


 


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Publications

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.

Wang H, Teriete P, Hu A, Raveendra-Panickar D, Pendelton K, Lazo JS, Eiseman J, Holien T, Misund K, Oliynyk G, Arsenian-Henriksson M, Cosford ND, Sundan A, Prochownik EV

Oncotarget 2015 Oct 20 ;6(32):32380-95

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Welsh K, Milutinovic S, Ardecky RJ, Gonzalez-Lopez M, Ganji SR, Teriete P, Finlay D, Riedl S, Matsuzawa S, Pinilla C, Houghten R, Vuori K, Reed JC, Cosford ND

PLoS One 2016 ;11(9):e0161952

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG

Mol Cell 2004 Feb 27 ;13(4):483-96

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Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.

Finlay D, Teriete P, Vamos M, Cosford NDP, Vuori K

F1000Res 2017 ;6:587

An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors.

Pagano N, Teriete P, Mattmann ME, Yang L, Snyder BA, Cai Z, Heil ML, Cosford NDP

Bioorg Med Chem 2017 Dec 1 ;25(23):6248-6265

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Welsh K, Milutinovic S, Ardecky RJ, Gonzalez-Lopez M, Ganji SR, Teriete P, Finlay D, Riedl S, Matsuzawa S, Pinilla C, Houghten R, Vuori K, Reed JC, Cosford ND

PLoS One 2016 ;11(9):e0161952

Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma.

Grimm M, Rieth J, Hoefert S, Krimmel M, Rieth S, Teriete P, Kluba S, Biegner T, Munz A, Reinert S

Eur Arch Otorhinolaryngol 2016 Oct ;273(10):3371-84

Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies.

Grimm M, Hoefert S, Krimmel M, Biegner T, Feyen O, Teriete P, Reinert S

Oral Maxillofac Surg 2016 Sep ;20(3):295-302

Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.

Grimm M, Feyen O, Coy JF, Hofmann H, Teriete P, Reinert S

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar ;121(3):301-6

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