Rolf Bodmer, Ph.D.

Rolf Bodmer's Research Focus

Cardiovascular Diseases, Heart Disease, Inherited Disorders, Muscular Dystrophy, Metabolic Syndrome, Metabolic Diseases, Obesity, Neurodegenerative and Neuromuscular Diseases, Parkinson's Disease, Cancer

The Bodmer Laboratory is interested in the molecular mechanisms of organ formation, how patterns are generated and how cells and tissue types assume their correct fates and functions. The Bodmer lab is pursuing this interest by studying the genetic functions and interactions that specify heart development and maintain heart performance in the Drosophila model, in the hope of elucidating basic principles in organogenesis and functionality.

Mesoderm

Cardiac Mesoderm

Cardiac Cell Types

Morphogenesis

Heart Function

Aging Heart

We study the HIF and Notch pathways in various organismal responses to hypoxia. Both of these pathways as well as mechanisms and responses to hypoxia are of high relevance to cancer research. 

We are also studying master regulatory networks in how they control metabolism and obesity. These fundamental studies on obesity pathways will also be highly relevant to cancer metabolism.

Rolf Bodmer's Bio

Rolf Bodmer earned his Ph.D. in Biochemistry and Neurobiology from the University of Basel, Switzerland, in 1983. Dr. Bodmer trained as a postdoctoral fellow in Neurobiology at the Albert Einstein College of Medicine in New York, and also studied Molecular Genetics at the University of California, San Francisco. He was appointed Assistant Professor of Biology in 1990 at the University of Michigan. There, he was promoted to Associate Professor of Biology in 1996, and then appointed to Associate Professor of Molecular, Cellular and Developmental Biology in 2001. Dr. Bodmer joined Sanford Burnham Prebys in 2003, where he is Professor and Program Director of the Development, Aging, and Regeneration Program.

 

Other Appointments

Adjunct professor, University of California, San Diego

 

Funding Awards and Collaborative Grants

1 P01 AG033561 "Genetic Analysis of Drosophila Functional Aging"

 

Honors and Recognition

Ellison Foundation Senior Scholar Award


DAR Accessory

Publications

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R

J Cell Biol 2011 Jun 27 ;193(7):1181-96

High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.

Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S

Cell Metab 2010 Nov 3 ;12(5):533-44

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM

Cell 2010 Apr 2 ;141(1):142-53

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Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.

Li H, Janssens J, De Waegeneer M, Kolluru SS, Davie K, Gardeux V, Saelens W, David FPA, Brbić M, Spanier K, Leskovec J, McLaughlin CN, Xie Q, Jones RC, Brueckner K, Shim J, Tattikota SG, Schnorrer F, Rust K, Nystul TG, Carvalho-Santos Z, Ribeiro C, Pal S, Mahadevaraju S, Przytycka TM, Allen AM, Goodwin SF, Berry CW, Fuller MT, White-Cooper H, Matunis EL, DiNardo S, Galenza A, O'Brien LE, Dow JAT, FCA Consortium§., Jasper H, Oliver B, Perrimon N, Deplancke B, Quake SR, Luo L, Aerts S, Agarwal D, Ahmed-Braimah Y, Arbeitman M, Ariss MM, Augsburger J, Ayush K, Baker CC, Banisch T, Birker K, Bodmer R, Bolival B, Brantley SE, Brill JA, Brown NC, Buehner NA, Cai XT, Cardoso-Figueiredo R, Casares F, Chang A, Clandinin TR, Crasta S, Desplan C, Detweiler AM, Dhakan DB, Donà E, Engert S, Floc'hlay S, George N, González-Segarra AJ, Groves AK, Gumbin S, Guo Y, Harris DE, Heifetz Y, Holtz SL, Horns F, Hudry B, Hung RJ, Jan YN, Jaszczak JS, Jefferis GSXE, Karkanias J, Karr TL, Katheder NS, Kezos J, Kim AA, Kim SK, Kockel L, Konstantinides N, Kornberg TB, Krause HM, Labott AT, Laturney M, Lehmann R, Leinwand S, Li J, Li JSS, Li K, Li K, Li L, Li T, Litovchenko M, Liu HH, Liu Y, Lu TC, Manning J, Mase A, Matera-Vatnick M, Matias NR, McDonough-Goldstein CE, McGeever A, McLachlan AD, Moreno-Roman P, Neff N, Neville M, Ngo S, Nielsen T, O'Brien CE, Osumi-Sutherland D, Özel MN, Papatheodorou I, Petkovic M, Pilgrim C, Pisco AO, Reisenman C, Sanders EN, Dos Santos G, Scott K, Sherlekar A, Shiu P, Sims D, Sit RV, Slaidina M, Smith HE, Sterne G, Su YH, Sutton D, Tamayo M, Tan M, Tastekin I, Treiber C, Vacek D, Vogler G, Waddell S, Wang W, Wilson RI, Wolfner MF, Wong YE, Xie A, Xu J, Yamamoto S, Yan J, Yao Z, Yoda K, Zhu R, Zinzen RP

Science 2022 Mar 4 ;375(6584):eabk2432

Depletion of cardiac cardiolipin synthase alters systolic and diastolic function.

Smeir E, Leberer S, Blumrich A, Vogler G, Vasiliades A, Dresen S, Jaeger C, Gloaguen Y, Klose C, Beule D, Schulze PC, Bodmer R, Foryst-Ludwig A, Kintscher U

iScience 2021 Nov 19 ;24(11):103314

Atrial Fibrillation Genomics: Discovery and Translation.

Yoo DH, Bodmer R, Ocorr K, Larson CJ, Colas AR, Muse ED

Curr Cardiol Rep 2021 Oct 1 ;23(11):164

Fat-body brummer lipase determines survival and cardiac function during starvation in Drosophila melanogaster.

Blumrich A, Vogler G, Dresen S, Diop SB, Jaeger C, Leberer S, Grune J, Wirth EK, Hoeft B, Renko K, Foryst-Ludwig A, Spranger J, Sigrist S, Bodmer R, Kintscher U

iScience 2021 Apr 23 ;24(4):102288

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk.

Pineda S, Nikolova-Krstevski V, Leimena C, Atkinson AJ, Altekoester AK, Cox CD, Jacoby A, Huttner IG, Ju YK, Soka M, Ohanian M, Trivedi G, Kalvakuri S, Birker K, Johnson R, Molenaar P, Kuchar D, Allen DG, van Helden DF, Harvey RP, Hill AP, Bodmer R, Vogler G, Dobrzynski H, Ocorr K, Fatkin D

Circ Genom Precis Med 2021 Apr ;14(2):e003144

Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila.

Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K

Cell Rep 2020 Dec 8 ;33(10):108445

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