Scott Peterson, Ph.D.

Scott Peterson's Research Focus

Cancer, Colorectal Cancer, Prostate Cancer, Autism Spectrum Disorders, Inflammatory/Autoimmune Disease, Autoimmune Disease

Dr. Peterson studies the human microbiome with a focus on pro-inflammatory species that may disrupt immune homeostasis and trigger early events of carcinogenesis. This research focus is complimented by efforts to characterize invasive bacteria that may penetrate defense systems and induce chronic inflammation.

Scott Peterson's Research Report

Gastrointestinal disorders are a significant co-morbidity of autism spectrum disorder (ASD). There is correlation between severity of GI symptoms and ASD phenotypes. Additional co-morbidities include autoimmune disease and food allergies. The progressive nature of ASD leads to a progressively lower quality of life for patients and their families. An important underlying condition of ASD is a “leaky gut”. Chronic gut barrier defects expose the extensive gut immune system to a barrage of food and microbial antigens leading to increased inflammation and susceptibility to food allergies and autoimmune diseases like IBD. Leaky gut may also allow the passage of bacterial toxins and metabolites that may not normally traverse the gut epithelium and generate neuroinflammation and toxicity. Toxin producing microbes may exert a significant physiological effect even when present at low abundance in the community. We have been extensively studying the gut microbiota modulatory potential of a wide variety of prebiotic carbohydrates. Each probiotic tested generates unique blooms of beneficial microbes including species like B. fragilis that is known to restore gut barrier integrity and still other species webs that directly modulate anti-inflammatory responses (Treg) and dendritic cell subsets. A significant therapeutic advantage of prebiotics is their ability to induce the expanded representation and activity of coherent groupings of species many of which are not FDA GRAS. In this regard we would like to further screening efforts of prebiotic compounds We envision a discovery platform to define prebiotic formulations (2 or more prebiotics) to allow broad flexibility to modulate the gut microbiota to best achieve restoration of gut barrier integrity and induction of anti-inflammatory pathways. Still other GRAS probiotics have the potential to alleviate additional GI symptoms such as diarrhea and constipation.

Scott Peterson's Bio

Peterson completed his Ph.D. at the University of North Carolina, Chapel Hill and his undergraduate degree at Rutgers University. He joined the J. Craig Venter Institute in 1996, rising to the level of professor before coming to Sanford Burnham (now SBP) in 2012. He won the Visiting Lecturer Award from the University of Orsay in France.


bioinformatics

Publications

Metabolite and Microbiome Interplay in Cancer Immunotherapy.

Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G

Cancer Res 2016 Nov 1 ;76(21):6146-6152

Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).

Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D

Sci Rep 2016 Sep 9 ;6:32609

Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.

Jones MB, Montgomery CP, Boyle-Vavra S, Shatzkes K, Maybank R, Frank BC, Peterson SN, Daum RS

BMC Genomics 2014 Dec 19 ;15:1145

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B-Vitamin Sharing Promotes Stability of Gut Microbial Communities.

Sharma V, Rodionov DA, Leyn SA, Tran D, Iablokov SN, Ding H, Peterson DA, Osterman AL, Peterson SN

Front Microbiol 2019 ;10:1485

Prebiotic Potential of Culinary Spices Used to Support Digestion and Bioabsorption.

Peterson CT, Rodionov DA, Iablokov SN, Pung MA, Chopra D, Mills PJ, Peterson SN

Evid Based Complement Alternat Med 2019 ;2019:8973704

Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.

Rodionov DA, Arzamasov AA, Khoroshkin MS, Iablokov SN, Leyn SA, Peterson SN, Novichkov PS, Osterman AL

Front Microbiol 2019 ;10:1316

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5<sup>-/-</sup> mice.

Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA

Nat Commun 2019 Apr 2 ;10(1):1492

16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics.

Peterson CT, Sharma V, Iablokov SN, Albayrak L, Khanipov K, Uchitel S, Chopra D, Mills PJ, Fofanov Y, Rodionov DA, Peterson SN

PLoS One 2019 ;14(3):e0213869

Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism.

Sharma V, Smolin J, Nayak J, Ayala JE, Scott DA, Peterson SN, Freeze HH

Cell Rep 2018 Sep 18 ;24(12):3087-3098

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