Sunnie Yoh's Research Focus
The overarching goal of my research is to understand regulatory networks operating on innate immune responses in distinguishing self from non-self stimuli and their contributions to development of autoimmune and neuro-degenerative diseases. Through combination of system-based and mechanistic approach, I study the regulatory protein complexes of innate immune pathways and exploit the protein interaction interfaces to identify small molecules with therapeutic potentials in various immune based diseases and treatment.
Sunnie Yoh's Bio
Publications
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
Yoh SM, Schneider M, Seifried J, Soonthornvacharin S, Akleh RE, Olivieri KC, De Jesus PD, Ruan C, de Castro E, Ruiz PA, Germanaud D, des Portes V, García-Sastre A, König R, Chanda SK
Cell 2015 Jun 4 ;161(6):1293-1305
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK
Nat Microbiol 2017 Mar 1 ;2:17022
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.
Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP
Cell Host Microbe 2016 Apr 13 ;19(4):515-528
Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.
Jain P, Boso G, Langer S, Soonthornvacharin S, De Jesus PD, Nguyen Q, Olivieri KC, Portillo AJ, Yoh SM, Pache L, Chanda SK
Cell Rep 2018 Feb 27 ;22(9):2493-2503
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK
Nat Microbiol 2017 Mar 1 ;2:17022
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.
Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP
Cell Host Microbe 2016 Apr 13 ;19(4):515-528
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
Yoh SM, Schneider M, Seifried J, Soonthornvacharin S, Akleh RE, Olivieri KC, De Jesus PD, Ruan C, de Castro E, Ruiz PA, Germanaud D, des Portes V, García-Sastre A, König R, Chanda SK
Cell 2015 Jun 4 ;161(6):1293-1305
The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.
Yoh SM, Lucas JS, Jones KA
Genes Dev 2008 Dec 15 ;22(24):3422-34
The multi-tasking P-TEFb complex.
Brès V, Yoh SM, Jones KA
Curr Opin Cell Biol 2008 Jun ;20(3):334-40