Tambet Teesalu, Ph.D.
Tambet Teesalu's Research Focus
Dr. Teesalu uses phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biological, and nanoparticles into tumors to increase their therapeutic index. His scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
Tambet Teesalu's Bio
Dr. Teesalu received his Ph.D. at University of Helsinki, Faculty of Medicine (jointly at San Raffaele Biomedical Institute in Milan, Italy) in 1999 studying the molecular mechanisms of mouse embryo implantation. He trained as a postdoctoral scientist with Antti Vaheri at the University of Helsinki, Finald until 2001. From 2001 to 2005, Dr. Teesalu was CEO of Applied Phenomics LLC, Tartu, Estonia. In 2005 he joined Dr. Ruoslahti's lab at SBP as a postdoctoral scientist and became a staff scientist. Dr. Teesalu is now an Adjunct Assistant Professor here and a Visiting Professor, Head of Laboratory of Cancer Biology at the University of Tartu, Estonia.
Teesalu T, Sugahara KN, Ruoslahti E
Methods Enzymol 2012 ;503:35-56
Fraikin JL, Teesalu T, McKenney CM, Ruoslahti E, Cleland AN
Nat Nanotechnol 2011 May ;6(5):308-13
Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Greenwald DR, Ruoslahti E
Science 2010 May 21 ;328(5981):1031-5
Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide.
Lepland A, Asciutto EK, Malfanti A, Simón-Gracia L, Sidorenko V, Vicent MJ, Teesalu T, Scodeller P
Mol Pharm 2020 Jun 1 ;
Lingasamy P, Tobi A, Kurm K, Kopanchuk S, Sudakov A, Salumäe M, Rätsep T, Asser T, Bjerkvig R, Teesalu T
Sci Rep 2020 Apr 2 ;10(1):5809
A novel CNS-homing peptide for targeting neuroinflammatory lesions in experimental autoimmune encephalomyelitis.
Acharya B, Meka RR, Venkatesha SH, Lees JR, Teesalu T, Moudgil KD
Mol Cell Probes 2020 Jun ;51:101530
Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction.
Torrieri G, Fontana F, Figueiredo P, Liu Z, Ferreira MPA, Talman V, Martins JP, Fusciello M, Moslova K, Teesalu T, Cerullo V, Hirvonen J, Ruskoaho H, Balasubramanian V, Santos HA
Nanoscale 2020 Jan 28 ;12(4):2350-2358
Lingasamy P, Tobi A, Haugas M, Hunt H, Paiste P, Asser T, Rätsep T, Kotamraju VR, Bjerkvig R, Teesalu T
Biomaterials 2019 Oct ;219:119373
Säälik P, Lingasamy P, Toome K, Mastandrea I, Rousso-Noori L, Tobi A, Simón-Gracia L, Hunt H, Paiste P, Kotamraju VR, Bergers G, Asser T, Rätsep T, Ruoslahti E, Bjerkvig R, Friedmann-Morvinski D, Teesalu T
J Control Release 2019 Aug 28 ;308:109-118