Yasuyuki Kihara, Ph.D.

Yasuyuki Kihara Profile

Yasuyuki Kihara, Ph.D.

Research Assistant Professor

Yasuyuki Kihara's Research Focus

G-Protein Coupled Receptors, Inflammation
  1. Discovery of therapeutic targets in multiple sclerosis (MS) and related neurological disorders.
  2. Systems biology approaches to the study of lipid mediators and G protein-coupled receptors (GPCRs).

Yasuyuki Kihara's Bio


Ph.D., University of Tokyo (JAPAN), Biochemistry and Molecular Biology
M.S., University of Tokyo (JAPAN), Medical Science
B.Pharm., Meiji Pharmaceutical University (JAPAN), Pharmacy


Honors and Recognition

HFSP Long-Term Fellowship, 2011-2014 
Japanese Society of Neuroimmunology Award, 2009



Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.

Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S

J Phys Chem B 2016 Aug 25 ;120(33):8346-53

Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models.

Kihara Y, Groves A, Rivera RR, Chun J

Ann Clin Transl Neurol 2015 Oct ;2(10):978-83

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.

Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA

Cell 2015 Jun 18 ;161(7):1633-43

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A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA<sub>1</sub>), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration.

González-Gil I, Zian D, Vázquez-Villa H, Hernández-Torres G, Martínez RF, Khiar-Fernández N, Rivera R, Kihara Y, Devesa I, Mathivanan S, Del Valle CR, Zambrana-Infantes E, Puigdomenech M, Cincilla G, Sanchez-Martinez M, Rodríguez de Fonseca F, Ferrer-Montiel AV, Chun J, López-Vales R, López-Rodríguez ML, Ortega-Gutiérrez S

J Med Chem 2020 Mar 12 ;63(5):2372-2390

LPA<sub>1/3</sub> overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction.

Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, Chun J

Sci Adv 2019 Oct ;5(10):eaax2011

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

Chun J, Kihara Y, Jonnalagadda D, Blaho VA

Annu Rev Pharmacol Toxicol 2019 Jan 6 ;59:149-170

Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry.

Mizuno H, Kihara Y, Kussrow A, Chen A, Ray M, Rivera R, Bornhop DJ, Chun J

J Lipid Res 2019 Jan ;60(1):212-217

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