Yu Xin (Will) Wang, Ph.D.

Yu Xin (Will) Wang's Research Focus

Aging-Related Diseases, Arthritis, Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease), Cachexia, Muscular Dystrophy, Myopathy, Sarcopenia/Aging-Related Muscle Atrophy, Spinal Muscular Atrophy, Neurodegenerative and Neuromuscular Diseases, Multiple Sclerosis, Inflammatory/Autoimmune Disease
Adult/Multipotent Stem Cells, Aging, Cell Signaling, Development and Differentiation, Exercise, Epigenetics, Extracellular Matrix, Neurogenesis, Organogenesis, Regenerative Biology, Transcriptional Regulation
Musculoskeletal System, Nervous System, Immune System and Inflammation
Computational Modeling, Clinical and Transitional Research, Human Adult/Somatic Stem Cells, Mouse, Computational Modeling
3D Image Analysis, Bioinformatics, Cellular and Molecular Imaging, Gene Knockout (Complete and Conditional), Genomics, High Content Imaging, High-Throughput/Robotic Screening, Machine Learning, Microscopy and Imaging, Transplantation, Proteomics, Live Cell Imaging

The Wang lab is interested in elucidating critical cell-cell interactions that mediate the function of tissue-specific stem cells during regeneration and disease, with a focus on

  1. how a coordinated immune response can promote regeneration and
  2. how autoimmunity impacts tissue function and hinder repair.

Specifically, the Wang lab aims to identify cellular and molecular crosstalk between muscle, nerve, and immune systems to develop targeted therapies that overcome autoimmune neuromuscular disorders and autoimmune aspects of “inflammaging.”

Yu Xin (Will) Wang's Research Report

The lab's research is translationally oriented and utilizes interdisciplinary molecular, genetic, computational (machine learning and neural networks), and bioengineering approaches to view biology and disease from new perspectives. We combine multi-omics sequencing and imaging methods to resolve how different cell types work together after injury to repair tissues and restore function. We use a data-driven approach to identify targetable disease mechanisms and, through collaborations with other researchers and clinicians, develop therapies that promote regeneration. Visit our lab website to learn more.

Yu Xin (Will) Wang's Bio

Dr. Yu Xin (Will) Wang received his Ph.D. at the University of Ottawa where he identified cellular asymmetry and polarity mechanisms regulating muscle stem cell self-renewal and skeletal muscle regeneration. He then carried out postdoctoral training at Stanford University School of Medicine developing single cell multi-omic approaches to characterize the regenerative process and what goes awry with disease and aging.  

"I've always had a passion for science and became fascinated with how the body repairs and heals itself when I was introduced to the potential of stem cells in regenerative medicine. I was struck by the ability of a small pool of muscle stem cells that can rebuild and restore the function of muscle. My lab at Sanford Burnham Prebys aims to better understanding the repair process and harness our body's ability to heal in order to combat chronic diseases and even counteract aging."

 

Education and Training

Postdoctoral Fellowship, Stanford University School of Medicine
Ph.D. in Cellular Molecular Medicine, University of Ottawa, Canada
B.S. in Biomedical Sciences, University of Ottawa, Canada

 

Prestigious Funding Awards

2020: NINDS K99/R00 Pathway to Independence Award

 

Honors and Recognition

Governor General’s Gold Medal - Canada


scientist with sample

Publications

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.

Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, Holbrook CA, Schürch CM, Ho ATV, Blau HM

Science 2021 Jan 29 ;371(6528)

EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions.

Wang YX, Feige P, Brun CE, Hekmatnejad B, Dumont NA, Renaud JM, Faulkes S, Guindon DE, Rudnicki MA

Cell Stem Cell 2019 Mar 7 ;24(3):419-432.e6

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.

Dumont NA, Wang YX, von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA

Nat Med 2015 Dec ;21(12):1455-63

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Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.

Palla AR, Hilgendorf KI, Yang AV, Kerr JP, Hinken AC, Demeter J, Kraft P, Mooney NA, Yucel N, Burns DM, Wang YX, Jackson PK, Blau HM

Nat Commun 2022 Mar 17 ;13(1):1439

Reversing aging for heart repair.

Wang YX, Blau HM

Science 2021 Sep 24 ;373(6562):1439-1440

Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments.

Madl CM, Flaig IA, Holbrook CA, Wang YX, Blau HM

Biomaterials 2021 Aug ;275:120973

AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency.

Markov GJ, Mai T, Nair S, Shcherbina A, Wang YX, Burns DM, Kundaje A, Blau HM

Proc Natl Acad Sci U S A 2021 Jun 8 ;118(23)

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function.

Yucel N, Wang YX, Mai T, Porpiglia E, Lund PJ, Markov G, Garcia BA, Bendall SC, Angelo M, Blau HM

Cell Rep 2019 Jun 25 ;27(13):3939-3955.e6

Macrophages rescue injured engineered muscle.

Wang YX, Blau HM

Nat Biomed Eng 2018 Dec ;2(12):890-891

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