Yuk-Lap (Kevin) Yip's Research Focus
We study gene regulatory mechanisms by means of computational modeling. To facilitate our data-centric approach, we develop novel methods for analyzing large amounts of biological data, including those produced by cutting-edge high-throughput experiments. Our computational models provide a systematic way to investigate the functional effects of different types of perturbations to regulatory mechanisms, which creates testable hypotheses for studying human diseases and facilitates translational research.
Links
Yuk-Lap (Kevin) Yip's Bio
Education and training
- Postdoctoral associate, Yale University, New Haven, Molecular Biophysics and Biochemistry, 2010
- Ph.D., Yale University, New Haven, Computer Science, 2009
- M.Phil., The University of Hong Kong, Hong Kong, Computer Science, 2003
- B.Eng., The University of Hong Kong, Hong Kong, Computer Engineering, 1999
Publications
An integrated encyclopedia of DNA elements in the human genome.
ENCODE Project Consortium.
Nature 2012 Sep 6 ;489(7414):57-74
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project.
Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, Feng X, Leng J, Vielle A, Niu W, Rhrissorrakrai K, Agarwal A, Alexander RP, Barber G, Brdlik CM, Brennan J, Brouillet JJ, Carr A, Cheung MS, Clawson H, Contrino S, Dannenberg LO, Dernburg AF, Desai A, Dick L, Dosé AC, Du J, Egelhofer T, Ercan S, Euskirchen G, Ewing B, Feingold EA, Gassmann R, Good PJ, Green P, Gullier F, Gutwein M, Guyer MS, Habegger L, Han T, Henikoff JG, Henz SR, Hinrichs A, Holster H, Hyman T, Iniguez AL, Janette J, Jensen M, Kato M, Kent WJ, Kephart E, Khivansara V, Khurana E, Kim JK, Kolasinska-Zwierz P, Lai EC, Latorre I, Leahey A, Lewis S, Lloyd P, Lochovsky L, Lowdon RF, Lubling Y, Lyne R, MacCoss M, Mackowiak SD, Mangone M, McKay S, Mecenas D, Merrihew G, Miller DM 3rd, Muroyama A, Murray JI, Ooi SL, Pham H, Phippen T, Preston EA, Rajewsky N, Rätsch G, Rosenbaum H, Rozowsky J, Rutherford K, Ruzanov P, Sarov M, Sasidharan R, Sboner A, Scheid P, Segal E, Shin H, Shou C, Slack FJ, Slightam C, Smith R, Spencer WC, Stinson EO, Taing S, Takasaki T, Vafeados D, Voronina K, Wang G, Washington NL, Whittle CM, Wu B, Yan KK, Zeller G, Zha Z, Zhong M, Zhou X, modENCODE Consortium., Ahringer J, Strome S, Gunsalus KC, Micklem G, Liu XS, Reinke V, Kim SK, Hillier LW, Henikoff S, Piano F, Snyder M, Stein L, Lieb JD, Waterston RH
Science 2010 Dec 24 ;330(6012):1775-87
Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines.
Cao Q, Anyansi C, Hu X, Xu L, Xiong L, Tang W, Mok MTS, Cheng C, Fan X, Gerstein M, Cheng ASL, Yip KY
Nat Genet 2017 Oct ;49(10):1428-1436
Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes.
Jiang G, Luk AO, Tam CHT, Ozaki R, Lim CKP, Chow EYK, Lau ES, Kong APS, Fan B, Hong Kong Diabetes Register TRS Study Group., Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JY, Tsang MW, Kam G, Lau IT, Li JK, Yeung VT, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Hong Kong Diabetes Biobank Study Group., Tang NLS, Huang Y, Lan HY, Oram RA, Szeto CC, So WY, Chan JCN, Ma RCW, Hong Kong Diabetes Register TRS Study Group:., Ma RCW, Chan JCN, Huang Y, Lan HY, Lok S, Tomlinson B, Tsui SKW, Yu W, Yip KYL, Chan TF, Fan X, So WY, Szeto CC, Tang NLS, Luk AO, Tian X, Jiang G, Tam CHT, Lee HM, Lim CKP, Chan KKH, Xie F, Ng ACW, Cheung GPY, Yeung MW, Mai S, Xie F, Zhang S, Yu P, Weng M, Hong Kong Diabetes Biobank Study Group:., Ma RCW, Chan JCN, Ozaki R, Luk AO, So WY, Lim CKP, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JYY, Tsang MW, Kam G, Cheung E, Lau IT, Li JK, Yeung VTF, Fung SKS, Lo S, Lau E, Cheng YL, Tsui SK, Huang Y, Lan HY, Yu W, Tomlinson B, Lok S, Chan TF, Yip KY, Szeto CC, Fan X, Tang NLS, Tian X, Tam CHT, Jiang G, Mai S, Fan B, Lau ES, Xie F, Zhang S, Yu P, Wang M, Lee HM, Xie F, Ng ACW, Cheung G, Kong APS, Chow EYK, Yeung MW, Chow CC, Cheung KKT, Wong RYM, Cheong SH, Chan KKH, Law CS, Lock AKY, Tsang IKY, Chan SCP, Chan YW, Chiu C, Hung CS, Ho CW, Ng IHY, Fok JMC, Lee KM, Leung HSC, Lee KW, Chan HM, Wat W, Lau T, Law R, Chan R, Lau C, Tsang P, Chan V, Ho LY, Wong E, Chan J, Lam SF, Pang J, Lee YM
Diabetes 2022 Mar 1 ;71(3):520-529
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis.
Wu F, Xu L, Tu Y, Cheung OK, Szeto LL, Mok MT, Yang W, Kang W, Cao Q, Lai PB, Chan SL, Tan P, Sung JJ, Yip KY, Cheng AS, To KF
Cancer Lett 2022 Jan 28 ;525:115-130
Quantifying full-length circular RNAs in cancer.
Yu KH, Shi CH, Wang B, Chow SH, Chung GT, Lung RW, Tan KE, Lim YY, Tsang AC, Lo KW, Yip KY
Genome Res 2021 Oct 18 ;
Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene.
Tan KE, Ng WL, Marinov GK, Yu KH, Tan LP, Liau ES, Goh SY, Yeo KS, Yip KY, Lo KW, Khoo AS, Yap LF, Ea CK, Lim YY
Sci Rep 2021 Jul 13 ;11(1):14392
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape.
Bruce JP, To KF, Lui VWY, Chung GTY, Chan YY, Tsang CM, Yip KY, Ma BBY, Woo JKS, Hui EP, Mak MKF, Lee SD, Chow C, Velapasamy S, Or YYY, Siu PK, El Ghamrasni S, Prokopec S, Wu M, Kwan JSH, Liu Y, Chan JYK, van Hasselt CA, Young LS, Dawson CW, Paterson IC, Yap LF, Tsao SW, Liu FF, Chan ATC, Pugh TJ, Lo KW
Nat Commun 2021 Jul 7 ;12(1):4193
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma.
Yang W, Feng Y, Zhou J, Cheung OK, Cao J, Wang J, Tang W, Tu Y, Xu L, Wu F, Tan Z, Sun H, Tian Y, Wong J, Lai PB, Chan SL, Chan AW, Tan PB, Chen Z, Sung JJ, Yip KY, To KF, Cheng AS
Sci Transl Med 2021 Apr 7 ;13(588)