Paper of the Week Somatic APP gene recombination in Alzheimer’s disease and normal neurons November 21, 2018 First description of somatic gene recombination in the brain. Involves RNA intermediates that are reverse transcribed and... Read more
Paper of the Week A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation October 22, 2018 Single heterozygous COG4 mutation causes Saul-Wilson Syndrome (SWS) SWS alters Golgi morphology, volume and trafficking SWS... Read more
Paper of the Week Accelerated aging and clearance of host anti-inflammatory enzymes by a subset of pathogens fuels sepsis October 10, 2018 The pathophysiology of sepsis can be stratified by pathogens and host responses Host neuraminidases induced by LPS activation... Read more
Paper of the Week Submegabase copy number variations arise during cerebral cortical neurogenesis as revealed by single-cell whole-genome sequencing October 8, 2018 New copy number variations (CNVs) were found in fetal brain cells. Most were below 1 Mb in size & found throughout the genome... Read more
Paper of the Week Regulation of S100A8 stability by RNF5 in intestinal epithelial cells determines intestinal inflammation and severity of colitis October 1, 2018 Severe intestinal inflammation resembling acute colitis in DSS-treated Rnf5−/− mice. RNF5 regulates S100A8 stability and pro... Read more
