Alexandre Colas, Ph.D.

Alexandre Colas' Research Focus

Heart Disease, Cardiovascular Diseases, Cardiomyopathies
Development and Differentiation, Embryonic/Pluripotent Stem Cells, Cardiovascular Biology, Regenerative Biology, Transcription Factors, RNA-Based Gene Regulation, Embryogenesis, Cell Biology

Our laboratory focuses on the identification and reconstruction of novel regulatory pathways controlling the determination and the acquisition of cardiovascular cell fates in humans. To that end, our team has developed a unique set of cell-based assays suitable for high-throughput functional screening, which enables the implementation of unbiased and systematic experimental approaches with unprecedented exploratory power. Our goal is to leverage generated knowledge to produce better cardiomyocytes to model cardiac diseases in-a-dish as well as to devise innovative cardiac regenerative strategies. In parallel, our lab is also dedicated to identify and develop new drugs promoting cardiac regeneration and/or helping preserving heart function after injury.

Alexandre Colas' Bio

Dr. Colas earned his Ph.D. from the Universite Pierre et Marie Curie, Paris, France.

Funding Awards and Collaborative Grants

  • American Heart Association Post-Doctoral Fellowship, 2011-2013
  • Best Talk Award (Development & Aging Post-Doctoral Retreat, SBP), 2011
  • California Institute for Regenerative Medicine Post-Doctoral Fellowship, 2010-2011
  • French Myopathy Association Ph.D. Fellowship, 2006-2007
  • Ministry of French Research Ph.D. Fellowship, 2003-2006
  • Erasmus Undergraduate Fellowship, 2000-2001
general accessory


Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G
PLoS One 2015;10(9):e0137894
Mercola M, Colas A, Willems E
Circ Res 2013 Feb 1;112(3):534-48
McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M
Curr Protoc Stem Cell Biol 2012 Nov;Chapter 1:Unit 1F.13
El Harane N, Kervadec A, Bellamy V, Pidial L, Neametalla HJ, Perier MC, Lima Correa B, Thiébault L, Cagnard N, Duché A, Brunaud C, Lemitre M, Gauthier J, Bourdillon AT, Renault MP, Hovhannisyan Y, Paiva S, Colas AR, Agbulut O, Hagège A, Silvestre JS, Menasché P, Renault NKE
Eur Heart J 2018 May 21;39(20):1835-1847
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M
Front Physiol 2017;8:766