Alexey Terskikh, Ph.D.

Alexey Terskikh's Research Focus

Brain Cancer, Breast Cancer, Parkinson's Disease

During development and in many adult tissues, stem cells are capable of self-renewal or differentiation depending on the extrinsic signals provided by the surrounding microenvironment (e.g., the stem cell niche). Many cancers are thought to be maintained by cancer initiating cells (sometimes called cancer stem cells), which often hijack stem cell self-renewal mechanisms. The Terskikh laboratory is interested in elucidating the molecular and cellular mechanisms underlying self-renewing and differentiation decisions using neural stem cells as a model, in particularly studying how this knowledge can be used to fight cancer.

Alexey Terskikh's Bio

Alexey Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996, in the laboratory of Prof. J.P. Mach, where he designed a new type of high-avidity recombinant molecule called Peptabody. He received postdoctoral training with Prof. Irving Weissman at Stanford University, where he discovered a common genetic program between hematopoietic and neural stem cells. Dr. Terskikh holds an Assistant Professor position in the Brain and Mind Institute at EPFL in Lausanne, Switzerland (2002-2006) and was recruited to SBP as Adjunct Assistant Professor in 2002 and as a full time Assistant Professor in 2006.

DAR Accessory


Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV
J Neurosci 2011 Jul 6;31(27):9933-44
Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV
Cell Stem Cell 2011 May 6;8(5):538-51
Shiryaev SA, Mesci P, Pinto A, Fernandes I, Sheets N, Shresta S, Farhy C, Huang CT, Strongin AY, Muotri AR, Terskikh AV
Sci Rep 2017 Nov 17;7(1):15771
Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG
Neuron 2019 Mar 20;101(6):1089-1098.e4
Gorshkov K, Shiryaev SA, Fertel S, Lin YW, Huang CT, Pinto A, Farhy C, Strongin AY, Zheng W, Terskikh AV
Front Microbiol 2018;9:3252
Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W
Cell Discov 2018;4:31